Camila Marques Freria
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View article: Thiorphan reprograms neurons to promote functional recovery after spinal cord injury
Thiorphan reprograms neurons to promote functional recovery after spinal cord injury Open
We previously identified an embryonic shift in the corticospinal motor neuronal transcriptome after spinal cord injury associated with successful axonal regeneration 1 . Exploiting this transcriptional regenerative ‘signature’, here we use…
View article: Neuroinflammation: targeting microglia for neuroprotection and repair after spinal cord injury
Neuroinflammation: targeting microglia for neuroprotection and repair after spinal cord injury Open
Neuroinflammation is a tightly regulated process essential for central nervous system (CNS) homeostasis, debris clearance, and defense against pathogens. Microglia, the resident immune cells of the CNS, are central to this response, suppor…
View article: Adaptation of a cervical bilateral contusive spinal cord injury for study of skilled forelimb function
Adaptation of a cervical bilateral contusive spinal cord injury for study of skilled forelimb function Open
We present an updated, clinically relevant model of moderately severe bilateral cervical level 6 contusive spinal cord injury (SCI) in the rat. This model is more clinically relevant than previous models due it its severity, yet animals re…
View article: Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury
Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury Open
We reported previously that neural progenitor cell (NPC) grafts form neural relays across sites of subacute spinal cord injury (SCI) and support functional recovery. Here, we examine whether NPC grafts after chronic delays also support rec…
View article: Methods for culturing adult CNS neurons reveal a CNS conditioning effect
Methods for culturing adult CNS neurons reveal a CNS conditioning effect Open
Neuronal cultures provide a basis for reductionist insights that rely on molecular and pharmacological manipulation. However, the inability to culture mature adult CNS neurons limits our understanding of adult neuronal physiology. Here, we…
View article: Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity
Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity Open
Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss and the disruption of neuronal connections across the injury site. While several experimental strategies have been used to minimize tissue damage …
View article: Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells
Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells Open
Microglia are dynamic immunosurveillance cells in the CNS. Whether microglia are protective or pathologic is context dependent; the outcome varies as a function of time relative to the stimulus, activation state of neighboring cells in the…
View article: Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice
Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice Open
Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic spinal contusion injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Here, we tested the hypo…
View article: Correlative Microscopy Application in Spinal Cord Injury Research
Correlative Microscopy Application in Spinal Cord Injury Research Open
Spinal cord injury (SCI) affects approximately 250,000 people in the United States, with about 11,000 new injuries each year.Neuron regeneration, a critical process to restore the communication between the body and the brain after SCI, is …