Camila S. Freitas
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View article: Blue light-emitting diode phototherapy presents in vitro efficacy against distinct Leishmania species and is therapeutic against tegumentary leishmaniasis in BALB/c mice
Blue light-emitting diode phototherapy presents in vitro efficacy against distinct Leishmania species and is therapeutic against tegumentary leishmaniasis in BALB/c mice Open
The treatment of tegumentary leishmaniasis (TL) faces significant challenges, including drug toxicity, high costs, and the emergence of resistant strains. These limitations highlight the urgent need for novel antileishmanial agents and the…
View article: Exploring the Scaffold Eugenol/1,2,3-Triazole in the Search for Alternative Agents for Leishmaniasis Treatment
Exploring the Scaffold Eugenol/1,2,3-Triazole in the Search for Alternative Agents for Leishmaniasis Treatment Open
View article: Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis
Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis Open
Visceral leishmaniasis (VL) is a tropical disease that can be fatal if acute and untreated. Diagnosis is difficult, the treatment is toxic and prophylactic vaccines do not exist. Leishmania parasites express hundreds of proteins and severa…
View article: Opposite effects of systemic and local conditional CD11c+ myeloid cell depletion during bleomycin‐induced inflammation and fibrosis in mice
Opposite effects of systemic and local conditional CD11c+ myeloid cell depletion during bleomycin‐induced inflammation and fibrosis in mice Open
Rationale Elevated levels of CD11c+ myeloid cells are observed in various pulmonary disorders, including Idiopathic Pulmonary Fibrosis (IPF). Dendritic cells (DCs) and macrophages (MΦ) are critical antigen‐presenting cells (APCs) that dire…
View article: Synthesis, Antileishmanial Activity, and in silico Study of 2-Hydroxy-3-(1,2,3-triazolyl)propyl Vanillin Derivatives
Synthesis, Antileishmanial Activity, and in silico Study of 2-Hydroxy-3-(1,2,3-triazolyl)propyl Vanillin Derivatives Open
This study details the preparation, antileishmanial assay, and in silico analysis of twenty 2-hydroxy-3-(1,2,3-triazolyl)propyl vanillin derivatives. These compounds were synthesized in three steps and evaluated against Leishmania infantum…
View article: Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis—mechanism of action and <i>in vivo</i> pharmacokinetic studies
Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis—mechanism of action and <i>in vivo</i> pharmacokinetic studies Open
Leishmaniasis is a parasitic neglected tropical disease, affecting 12 million people. Available treatments present several limitations, with an increasing number of resistance cases. In the search for new chemotherapies, the natural produc…
View article: Comparison of urine and serum IgG detection ELISA for tegumentary leishmaniasis diagnosis and prognosis
Comparison of urine and serum IgG detection ELISA for tegumentary leishmaniasis diagnosis and prognosis Open
Laboratorial diagnosis of tegumentary leishmaniasis (TL) is hampered by variable sensitivity and/or specificity of the tests, which are still hampered by blood́ invasive collection. In this context, in the present study, we develop a serum-…
View article: Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism
Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism Open
View article: Sub-seasonal streamflow forecasts for hydropower dams in the Brazilian Eletrical Interconnected System
Sub-seasonal streamflow forecasts for hydropower dams in the Brazilian Eletrical Interconnected System Open
Inflow prediction on sub-seasonal timescale have the potential for important contributions to the management of water resources in hydroelectric dam operations. These forecasts challenge the limitations of the medium-term and extend it, br…
View article: Validação do Mnemônico NUTRIFICO como Abordagem Nutricional e Comunicação de Notícias Difíceis em Cuidados Paliativos
Validação do Mnemônico NUTRIFICO como Abordagem Nutricional e Comunicação de Notícias Difíceis em Cuidados Paliativos Open
Introdução: A assistência nutricional em cuidados paliativos possui papel preventivo e visa assegurar as necessidades nutricionais do paciente na tentativa de auxiliar o controle dos sintomas, manter a hidratação satisfatória, ressignifica…
View article: B-Cell Epitopes-Based Chimeric Protein from SARS-CoV-2 N and S Proteins Is Recognized by Specific Antibodies in Serum and Urine Samples from Patients
B-Cell Epitopes-Based Chimeric Protein from SARS-CoV-2 N and S Proteins Is Recognized by Specific Antibodies in Serum and Urine Samples from Patients Open
The impact of the COVID-19 pandemic caused by the SARS-CoV-2 virus underscored the crucial role of laboratorial tests as a strategy to control the disease, mainly to indicate the presence of specific antibodies in human samples from infect…
View article: Synthesis of 1,2,3-Triazole-Containing Methoxylated Cinnamides and Their Antileishmanial Activity against the Leishmania braziliensis Species
Synthesis of 1,2,3-Triazole-Containing Methoxylated Cinnamides and Their Antileishmanial Activity against the Leishmania braziliensis Species Open
Leishmaniasis is a group of infectious diseases caused by protozoan parasites that belong to the genus Leishmania. Currently, there is no human vaccine, and the available treatments are associated with toxicity, high cost, and the emergenc…
View article: Seasonal streamflow forecasting in South America’s largest rivers
Seasonal streamflow forecasting in South America’s largest rivers Open
Study region: South America large basins (>5000 km²) Study focus: This work represents a first assessment of seasonal streamflow forecasts in South America based on a continental-scale application of a large scale hydrologic-hydrodynamic m…
View article: Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp
Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp Open
Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Methods: Hence, this stud…
View article: Efficacy of an Immunotherapy Combining Immunogenic Chimeric Protein Plus Adjuvant and Amphotericin B against Murine Visceral Leishmaniasis
Efficacy of an Immunotherapy Combining Immunogenic Chimeric Protein Plus Adjuvant and Amphotericin B against Murine Visceral Leishmaniasis Open
Visceral leishmaniasis (VL) in the Americas is a chronic systemic disease caused by infection with Leishmania infantum parasites. The toxicity of antileishmanial drugs, long treatment course and limited efficacy are significant concerns th…
View article: Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp
Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp Open
Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Methods: Hence, this stud…
View article: Atmospheric and oceanic influences on the hydrological scenarium southern Brazil in relation to extreme events observed in 2022
Atmospheric and oceanic influences on the hydrological scenarium southern Brazil in relation to extreme events observed in 2022 Open
After a long period of drought experienced in South America, which began in 2019 and lasted until 2021 for the southern region of Brazil, the hydrological scenario of this region presented positive precipitation anomalies throughout the ye…
View article: Evaluation of a global precipitation product in the hydrological modeling of a river in the Amazon basin.
Evaluation of a global precipitation product in the hydrological modeling of a river in the Amazon basin. Open
In rainfall-runoff modeling, the main input variable is precipitation, and the understanding of its temporal and spatial variation is the key for good hydrological simulation results. Conventionally, the precipitated volumes are measured b…
View article: Hydrometeorological System for Seasonal Streamflow Forecasting at Brazilian Hydro Power Enterprises
Hydrometeorological System for Seasonal Streamflow Forecasting at Brazilian Hydro Power Enterprises Open
The Electric Energy Company of Parana (COPEL GeT), the Meteorological System of Parana (SIMEPAR) and RHAMA Consulting company are undertaking the research project PD-6491-0503/2018 for the development of a hydrometeorological seasonal fore…
View article: Evaluation of four hydrological models to simulate daily streamflow time series in a tropical river basin of Brazil
Evaluation of four hydrological models to simulate daily streamflow time series in a tropical river basin of Brazil Open
The Electric Energy Company of Parana (COPEL GeT), the Meteorological System of Parana (SIMEPAR) and RHAMA Consulting company are undertaking the research project PD-6491- 0503/2018 for the development of a hydrometeorological seasonal for…
View article: Verification of ECMWF SEAS5 precipitation seasonal forecasting using ERA5 and observations for Brazilian Hidro Power Plants
Verification of ECMWF SEAS5 precipitation seasonal forecasting using ERA5 and observations for Brazilian Hidro Power Plants Open
The Electric Energy Company of Parana (COPEL GeT), the Meteorological System of Parana (SIMEPAR) and RHAMA Consulting company are undertaking the research project PD-6491-0503/2018 for the development of a hydrometeorological seasonal fore…
View article: ANALYSIS OF SUB SEASONAL STREAMFLOW FORECASTS FOR HPPs RESERVOIRS AT SOUTH AMERICA BASED ON ECMWF AND GEFS MODELS DATA
ANALYSIS OF SUB SEASONAL STREAMFLOW FORECASTS FOR HPPs RESERVOIRS AT SOUTH AMERICA BASED ON ECMWF AND GEFS MODELS DATA Open
The flow forecast is used in several sectors of society, bringing benefits in relation to the mitigation of possible impacts in flood events and it is information of great value for the economic sectors associated with agriculture and ener…
View article: Short- to seasonal-range streamflow forecasting in reservoirs of the Brazilian National Interconnect Electric Power System
Short- to seasonal-range streamflow forecasting in reservoirs of the Brazilian National Interconnect Electric Power System Open
The Electric Energy Company of Parana (COPEL GeT), the Meteorological System of Parana (SIMEPAR) and RHAMA Consulting company are undertaking the research project PD-6491-0503/2018 for the development of a hydrometeorological seasonal fore…
View article: Medium range ensemble streamflow forecasts for hydropower dams of the Brazilian National Interconnected System
Medium range ensemble streamflow forecasts for hydropower dams of the Brazilian National Interconnected System Open
Short-to-medium range streamflow forecasting is essential for planning and operating hydropower plants (HPPs). The Brazilian National Interconnected System (SIN) is composed of more than 150 HPPs that are located over a wide range of clima…
View article: Evaluation of Seasonal Streamflow Forecasts over South American Large Rivers
Evaluation of Seasonal Streamflow Forecasts over South American Large Rivers Open
Society’s increasing demand for water and the need for its long-term management have motivated efforts toward improving seasonal streamflow forecasts. Currently, seasonal climate forecasts are routinely issued in meteorological cente…
View article: Continental-scale evaluation of subseasonal–to–seasonal (S2S) streamflow forecasts over South America
Continental-scale evaluation of subseasonal–to–seasonal (S2S) streamflow forecasts over South America Open
Hydrological forecasts ranging from two weeks to months in advance are critical for decision making in water resources management and economic sectors. In the subseasonal timescale, there is an opportunity to anticipate events of hydrologi…
View article: Immunotherapy Using Immunogenic Mimotopes Selected by Phage Display plus Amphotericin B Inducing a Therapeutic Response in Mice Infected with Leishmania amazonensis
Immunotherapy Using Immunogenic Mimotopes Selected by Phage Display plus Amphotericin B Inducing a Therapeutic Response in Mice Infected with Leishmania amazonensis Open
Leishmania amazonensis can cause cutaneous and visceral clinical manifestations of leishmaniasis in infected hosts. Once the treatment against disease is toxic, presents high cost, and/or there is the emergence of parasite-resistant strain…
View article: Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp
Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp Open
Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Methods: Hence, this stud…
View article: Green Synthesis, Characterization and Antibacterial and Leishmanicidal Activities of Silver Nanoparticles Obtained from Aqueous Extract of Eucalyptus grandis
Green Synthesis, Characterization and Antibacterial and Leishmanicidal Activities of Silver Nanoparticles Obtained from Aqueous Extract of Eucalyptus grandis Open
This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic…
View article: <i>In silico</i>-based screening for natural product’s structural analogs as new drugs candidate against leishmaniasis
<i>In silico</i>-based screening for natural product’s structural analogs as new drugs candidate against leishmaniasis Open
Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Hence, this study aims to in silico scr…