Camilla A. Richmond
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View article: Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab
Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab Open
Background There is a need to identify peripheral biomarkers reflective of defined disease associated fibroblasts in Ulcerative Colitis (UC), with the aim of enabling clinical development approaches for novel‐stromal‐targeted therapeutics …
View article: Understanding the adult and adolescent patient experience with cyclic vomiting syndrome: a concept elicitation study
Understanding the adult and adolescent patient experience with cyclic vomiting syndrome: a concept elicitation study Open
Patients with CVS experience considerable gastrointestinal and extra-intestinal symptoms. CVS impacts the activities of daily life of patients and their caregivers, with patients reporting negative effects of CVS on their emotional status …
View article: Long-term Safety and Efficacy of Budesonide Oral Suspension for Eosinophilic Esophagitis: A 4-Year, Phase 3, Open-Label Study
Long-term Safety and Efficacy of Budesonide Oral Suspension for Eosinophilic Esophagitis: A 4-Year, Phase 3, Open-Label Study Open
gov number: NCT03245840.
View article: Symptom Patterns in Adults With Cyclic Vomiting Syndrome: A 6‐Month Prospective Observational Study
Symptom Patterns in Adults With Cyclic Vomiting Syndrome: A 6‐Month Prospective Observational Study Open
Background Data are limited on the natural history and symptom patterns of cyclic vomiting syndrome (CVS), a disorder of gut–brain interaction characterized by recurrent stereotypical vomiting, retching, and nausea episodes. Methods A 6‐mo…
View article: Effect of Food on the Pharmacokinetics, Safety, and Tolerability of Budesonide Oral Suspension in Healthy Adult Participants: A Randomized Phase 1 Study
Effect of Food on the Pharmacokinetics, Safety, and Tolerability of Budesonide Oral Suspension in Healthy Adult Participants: A Randomized Phase 1 Study Open
Budesonide oral suspension (BOS) is a swallowed corticosteroid indicated for 12‐week therapy in eosinophilic esophagitis with minimal systemic exposure following administration. We aimed to assess the relative bioavailability of a single d…
View article: Human colon-on-a-chip enables continuous <i>in vitro</i> analysis of colon mucus layer accumulation and physiology
Human colon-on-a-chip enables continuous <i>in vitro</i> analysis of colon mucus layer accumulation and physiology Open
Background & Aims The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understandin…
View article: Species-specific enhancement of enterohemorrhagic <i>E. Coli</i> pathogenesis mediated by microbiome metabolites
Species-specific enhancement of enterohemorrhagic <i>E. Coli</i> pathogenesis mediated by microbiome metabolites Open
Background Species-specific differences in tolerance to infection are exemplified by the high susceptibility of humans to enterohemorrhagic E. coli (EHEC) infection whereas mice are relatively resistant to this pathogen. This intrinsic spe…
View article: Additional file 9: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 9: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S2. List of 30 known metabolites enriched in Hmm compared to Mmm that were selected for fliC-luciferase screening (CAS n: Chemical Abstracts Service number; “name”: metabolites with a known name; “similarity”: closest MSMS spectrum i…
View article: Additional file 5: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 5: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S1. Transcriptomics analysis of long polar fimbriae genes.. (XLSX 8â kb)
View article: Additional file 15: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 15: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S3. Reagents and resources. (XLSX 16â kb)
View article: Additional file 16: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
Additional file 16: of Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites Open
Table S4. 16â s rRNA gene data. (CSV 291â kb)
View article: Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids Open
Here we describe a method for fabricating a primary human Small Intestine-on-a-Chip (Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal biopsies. The primary epithelial cells are expanded as 3D organoid…
View article: An enduring role for quiescent stem cells
An enduring role for quiescent stem cells Open
The intestine's ability to recover from catastrophic injury requires quiescent intestinal stem cells (q‐ISCs). While rapidly cycling (Lgr5+) crypt base columnar (CBC) ISCs normally maintain the intestine, they are highly sensitive to patho…