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View article: A Challenging Diagnosis of Hemophagocytic Lymphohistiocytosis with Unusual Pulmonary Manifestations: A Case Report
A Challenging Diagnosis of Hemophagocytic Lymphohistiocytosis with Unusual Pulmonary Manifestations: A Case Report Open
Introduction Hemophagocytic Lymphohistiocytosis (HLH) is a rare, aggressive, and life-threatening disorder characterized by sustained but ineffective immune system activation that leads to severe and systemic hyperinflammation. It may occu…
View article: KRAS G12C inhibition enhances efficacy to conventional chemotherapy in KRAS-mutant NSCLC
KRAS G12C inhibition enhances efficacy to conventional chemotherapy in KRAS-mutant NSCLC Open
Despite recent therapeutic advances, the adjuvant treatment of non-small cell lung cancer (NSCLC) remains a challenge. Reducing the risk of recurrence is still a concern, especially in the KRAS G12C population, for which platinum-based adj…
View article: EGFR Mutation Detection in Whole Slide Images of Non‐Small Cell Lung Cancers Using a Two‐Stage Deep Transfer Learning Approach
EGFR Mutation Detection in Whole Slide Images of Non‐Small Cell Lung Cancers Using a Two‐Stage Deep Transfer Learning Approach Open
Background Lung cancer (LC) is the leading cause of cancer death worldwide. Non‐small cell lung cancer is the most frequent and includes adenocarcinoma and squamous cell carcinoma. Currently, LC treatment is based on tumor molecular profil…
View article: Circulating Tumor Cell-Free DNA as Prognostic Biomarker in Non-Small Cell Lung Cancer Patients Undergoing Immunotherapy: The CORELAB Experience
Circulating Tumor Cell-Free DNA as Prognostic Biomarker in Non-Small Cell Lung Cancer Patients Undergoing Immunotherapy: The CORELAB Experience Open
The expression level of Programmed Death-Ligand 1 (PD-L1) determined by the immunohistochemical method is currently approved to test the potential efficacy of immune-checkpoint inhibitors and to candidate patients with Non-Small Cell Lung …
View article: Genetic signatures of <i>ERCC1</i> and <i>ERCC2</i> expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy
Genetic signatures of <i>ERCC1</i> and <i>ERCC2</i> expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy Open
The comprehensive analysis of ERCC gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.
View article: Utility of bronchoalveolar lavage for COVID-19: a perspective from the Dragon consortium
Utility of bronchoalveolar lavage for COVID-19: a perspective from the Dragon consortium Open
Diagnosing COVID-19 and treating its complications remains a challenge. This review reflects the perspective of some of the Dragon (IMI 2-call 21, #101005122) research consortium collaborators on the utility of bronchoalveolar lavage (BAL)…
View article: ERCC1 and ERCC2 genes expression and their SNPs variants identify a favorable signature for SCLC patients treated with platinum-based chemotherapy
ERCC1 and ERCC2 genes expression and their SNPs variants identify a favorable signature for SCLC patients treated with platinum-based chemotherapy Open
Background: Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damages exerted by …
View article: KRAS Mutations Are Associated with Shortened Survival in Patients with Epithelioid Malignant Pleural Mesothelioma
KRAS Mutations Are Associated with Shortened Survival in Patients with Epithelioid Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is an aggressive malignancy of the pleural surface that includes three major histologic subtypes, epitheliod, sarcomatoid and biphasic. Epithelioid mesothelioma is usually associated with better prognos…
View article: KRAS G12 isoforms exert influence over up-front treatments: A retrospective, multicenter, Italian analysis of the impact of first-line immune checkpoint inhibitors in an NSCLC real-life population
KRAS G12 isoforms exert influence over up-front treatments: A retrospective, multicenter, Italian analysis of the impact of first-line immune checkpoint inhibitors in an NSCLC real-life population Open
Background KRAS is commonly mutated in non-small cell lung cancer (NSCLC); however, the prognostic and predictive impact of each G12 substitution has not been fully elucidated. The approval of specific G12C inhibitors has modified the idea…
View article: Phenotypes of Post-COVID-19 Interstitial Lung Disease: Clinical, Radiological, and Pathological Correlations
Phenotypes of Post-COVID-19 Interstitial Lung Disease: Clinical, Radiological, and Pathological Correlations Open
Pulmonary sequelae after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from limited abnormalities to major interstitial lung diseases (ILD). Bronchoalveolar lavage (BAL) and cryobiopsy findings, integrated wi…
View article: Gender Matters. Sex-related Differences in Immunotherapy Outcome in Patients with Non-small Cell Lung Cancer
Gender Matters. Sex-related Differences in Immunotherapy Outcome in Patients with Non-small Cell Lung Cancer Open
Background: Emerging evidence identified sex as a variable regulating immune system functions and modulating response to immunotherapy in cancer patients. Objective: This retrospective study analysed sex-related differences in immunotherap…
View article: Utility of bronchoalveolar lavage for COVID-19: a perspective from the Dragon consortium.
Utility of bronchoalveolar lavage for COVID-19: a perspective from the Dragon consortium. Open
Diagnosing COVID-19 and treating its complications remains a challenge. This review reflects the perspective of some of the Dragon (IMI 2-call 21, #101005122) research consortium collaborators on the utility of bronchoalveolar lavage (BAL)…
View article: Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives
Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives Open
The incidental discovery of pre-clinical interstitial lung disease (ILD) has led to the designation of interstitial lung abnormalities (ILA), a radiological entity defined as the incidental finding of computed tomography (CT) abnormalities…
View article: Gastric and colonic metastasis from NSCLC
Gastric and colonic metastasis from NSCLC Open
Rationale: Lung cancer is the most common cause of cancer-related deaths worldwide. Approximately 50% of patients is metastatic at diagnosis and the most common metastatic sites are bone, lungs, brain, adrenal glands, liver, and extra thor…
View article: Absolute eosinophil count predicts clinical outcomes and toxicity in non-small cell lung cancer patients treated with immunotherapy
Absolute eosinophil count predicts clinical outcomes and toxicity in non-small cell lung cancer patients treated with immunotherapy Open
High baseline AEC value (≥130/μL) is a predictive biomarker of clinical benefit and irAEs occurrence in NSCLC patients treated with ICIs.
View article: Induction Chemotherapy Followed by Pleurectomy Decortication and Hyperthermic Intraoperative Chemotherapy (HITHOC) for Early-Stage Epitheliod Malignant Pleural Mesothelioma—A Prospective Report
Induction Chemotherapy Followed by Pleurectomy Decortication and Hyperthermic Intraoperative Chemotherapy (HITHOC) for Early-Stage Epitheliod Malignant Pleural Mesothelioma—A Prospective Report Open
Malignant pleural mesothelioma (MPM) is an aggressive disease with poor prognosis and the current treatment for early-stage MPM is based on a multimodality therapy regimen involving platinum-based chemotherapy preceding or following surger…
View article: Primary pleural epithelioid hemangioendothelioma: case report and review of the literature
Primary pleural epithelioid hemangioendothelioma: case report and review of the literature Open
Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular sarcoma with an unpredictable clinical behavior. Pleural EHEs have been associated with poor response to treatment and reduced survival. To date, no standard treatment fo…
View article: Screen-detected multiple primary lung cancers in the ITALUNG trial
Screen-detected multiple primary lung cancers in the ITALUNG trial Open
Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical tri…
View article: Gorham-Stout Disease Management during Pregnancy
Gorham-Stout Disease Management during Pregnancy Open
Gorham-Stout Disease (GSD) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. It is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulm…
View article: Does videomediastinoscopy with frozen sections improve mediastinal staging during video-assisted thoracic surgery pulmonary resections?
Does videomediastinoscopy with frozen sections improve mediastinal staging during video-assisted thoracic surgery pulmonary resections? Open
Based on our experience, the combination "VM with FS followed by VMPRS in sequence", seems to be effective and offers an alternative approach to improve intraoperative mediastinal staging.