Camilla Lagheden
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View article: Exposometer-based assessment of laboratory work environment
Exposometer-based assessment of laboratory work environment Open
Human health is impacted by a wide range of exposures, including biological, chemical, and physical factors, making it challenging to assess their combined environmental health effects comprehensively. Advances in wearable and stationary s…
View article: Controlled trial of cervical cancer screening frequency among human‐papillomavirus‐vaccinated women
Controlled trial of cervical cancer screening frequency among human‐papillomavirus‐vaccinated women Open
Cervical screening frequency has not been studied in vaccinees. As the major risk factor, oncogenic human papillomavirus (HPV) is declining due to vaccination. We report a trial to assess the effectiveness of cervical screening frequency a…
View article: Assessing sample adequacy and clinical performance of self-collected and clinician-collected HPV specimens using internal control Ct values
Assessing sample adequacy and clinical performance of self-collected and clinician-collected HPV specimens using internal control Ct values Open
View article: The Human Papillomavirus (HPV) Laboratory e-Manual: A comprehensive guide for HPV testing and research
The Human Papillomavirus (HPV) Laboratory e-Manual: A comprehensive guide for HPV testing and research Open
The HPV Laboratory e-Manual represents a step toward global harmonization in laboratory methodologies for HPV testing, underpinning both research and cervical cancer control efforts.
View article: Assessing Sample Adequacy and Clinical Performance of Self-Collected and Clinician-Collected HPV Specimens Using Internal Control Ct Values
Assessing Sample Adequacy and Clinical Performance of Self-Collected and Clinician-Collected HPV Specimens Using Internal Control Ct Values Open
View article: Continuous Global Improvement of Human Papillomavirus (HPV) Genotyping Services: The 2022 and 2023 HPV LabNet International Proficiency Studies
Continuous Global Improvement of Human Papillomavirus (HPV) Genotyping Services: The 2022 and 2023 HPV LabNet International Proficiency Studies Open
The International Human Papillomavirus (HPV) Reference Center launches annual global HPV genotyping proficiency panels to enhance the precision and international standardization of HPV genotyping services. This study aims to assess the pro…
View article: Seroepidemiological assessment of the spread of SARS-CoV-2 among 25 and 28 year-old adult women in Finland between March 2020-June 2022
Seroepidemiological assessment of the spread of SARS-CoV-2 among 25 and 28 year-old adult women in Finland between March 2020-June 2022 Open
Introduction Serological surveys of the prevalence of SARS-CoV-2 are instrumental to understanding the course of the COVID-19 epidemic. We evaluate the seroprevalence of SARS-CoV-2 among young adult Finnish females residing in 25 communiti…
View article: Low methylation marker levels among human papillomavirus‐vaccinated women with cervical high‐grade squamous intraepithelial lesions
Low methylation marker levels among human papillomavirus‐vaccinated women with cervical high‐grade squamous intraepithelial lesions Open
Cervical cancer screening programs, including triage tests, need redesigning as human papillomavirus (HPV)‐vaccinated women are entering the programs. Methylation markers offer a potential solution to reduce false‐positive rates by identif…
View article: Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer
Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer Open
View article: Human papillomavirus negative high grade cervical lesions and cancers: Suggested guidance for HPV testing quality assurance
Human papillomavirus negative high grade cervical lesions and cancers: Suggested guidance for HPV testing quality assurance Open
View article: The International Human Papillomavirus Reference Center: Standardization, collaboration, and quality assurance in HPV research and diagnostics
The International Human Papillomavirus Reference Center: Standardization, collaboration, and quality assurance in HPV research and diagnostics Open
The International Human Papillomavirus (HPV) Reference Center (IHRC) confirms and assigns type numbers to novel HPV types, maintains a reference clone repository, and issues international proficiency panels for HPV screening and genotyping…
View article: Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts
Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts Open
The long-term effect of population-level human papillomavirus (HPV) vaccination on the viral ecology of the untargeted HPVs is poorly understood. We performed an 8-year follow-up of 33 communities randomized to gender-neutral HPV16/18 vacc…
View article: Impact of cervical screening by human papillomavirus genotype: Population-based estimations
Impact of cervical screening by human papillomavirus genotype: Population-based estimations Open
Background Cervical screening programs use testing for human papillomavirus (HPV) genotypes. Different HPV types differ greatly in prevalence and oncogenicity. We estimated the impact of cervical screening and follow-up for each HPV type. …
View article: Concomitant Human Papillomavirus (HPV) Vaccination and HPV Screening for Rapid Elimination of HPV Infection and Cervical Cancer
Concomitant Human Papillomavirus (HPV) Vaccination and HPV Screening for Rapid Elimination of HPV Infection and Cervical Cancer Open
We describe a nationwide implementation trial of concomitant Human Papillomavirus (HPV) vaccination and HPV screening of young women to reduce the incidence of HPV and provide HPV screening-mediated protection against cervical cancer. All …
View article: First international proficiency study on human papillomavirus testing in cervical cancer screening
First international proficiency study on human papillomavirus testing in cervical cancer screening Open
Internationally recognized proficiency studies of HPV screening, traceable to international standards, provided an overview of current testing performance. There was a high level of proficiency in terms of sensitivity and few false positiv…
View article: Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
The human papillomavirus (HPV) rate of evolution is essential for cancer-preventive strategies targeting HPV. We analyzed variability over time in a prospective, population-based nested case–control study of in situ (CIS) and invasi…
View article: Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
Supplementary Table 3. SNPs in serial smears
View article: Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
Supplementary Table 3. SNPs in serial smears
View article: Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
Supplementary Table 1: Nucleotide variant calls detected over time in pairs of serial cervical smears from 94 women.
View article: Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
Supplementary Table 2: Substitution rate in substitutions/site/year by quartile of follow-up time in months
View article: Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
The human papillomavirus (HPV) rate of evolution is essential for cancer-preventive strategies targeting HPV. We analyzed variability over time in a prospective, population-based nested case–control study of in situ (CIS) and invasi…
View article: Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
Supplementary Table 1: Nucleotide variant calls detected over time in pairs of serial cervical smears from 94 women.
View article: Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study
Supplementary Data from The HPV16 Genome Is Stable in Women Who Progress to <i>In Situ</i> or Invasive Cervical Cancer: A Prospective Population-Based Study Open
Supplementary Table 2: Substitution rate in substitutions/site/year by quartile of follow-up time in months
View article: Human Papillomavirus Negative High Grade Cervical Lesions and Cancers: Suggested Guidance for Hpv Testing Quality Assurance
Human Papillomavirus Negative High Grade Cervical Lesions and Cancers: Suggested Guidance for Hpv Testing Quality Assurance Open
View article: Metatranscriptome analysis in human papillomavirus negative cervical cancers
Metatranscriptome analysis in human papillomavirus negative cervical cancers Open
View article: Improving human papillomavirus (HPV) testing in the cervical cancer elimination era: The 2021 HPV LabNet international proficiency study
Improving human papillomavirus (HPV) testing in the cervical cancer elimination era: The 2021 HPV LabNet international proficiency study Open
The worldwide deterioration in comparability and reliability of HPV testing found in 2019 is now reversed and an overall increase in proficiency is found.
View article: Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses
Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses Open
For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vac…
View article: Human Papillomavirus Types in Invasive Cervical Cancer in Relation to Cervical Screening
Human Papillomavirus Types in Invasive Cervical Cancer in Relation to Cervical Screening Open
View article: Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial Open
Background Human papillomavirus (HPV) vaccination protects against HPV, a necessary risk factor for cervical cancer. We now report results from population-based follow-up of randomised cohorts that vaccination provides HPV-type-specific pr…
View article: Audit of laboratory sensitivity of human papillomavirus and cytology testing in a cervical screening program
Audit of laboratory sensitivity of human papillomavirus and cytology testing in a cervical screening program Open
The globally recommended public health policy for cervical screening is primary human papillomavirus (HPV) screening with cytology triaging of positives. To ensure optimal quality of laboratory services we have conducted regular audits of …