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View article: Unraveling Tumor Heterogeneity in Gynecological Cancer Using a Radiogenomics Approach
Unraveling Tumor Heterogeneity in Gynecological Cancer Using a Radiogenomics Approach Open
Ovarian cancer (OC) and endometrial cancer (EC) are highly heterogeneous gynecological malignancies with distinct molecular subtypes, therapeutic responses, and clinical outcomes. Traditional biopsy-based profiling often fails to capture t…
View article: Detection of Clinically Significant BRCA Large Genomic Rearrangements in FFPE Ovarian Cancer Samples: A Comparative NGS Study
Detection of Clinically Significant BRCA Large Genomic Rearrangements in FFPE Ovarian Cancer Samples: A Comparative NGS Study Open
Background: Copy number variations (CNVs), also referred to as large genomic rearrangements (LGRs), represent a crucial component of BRCA1/2 (BRCA) testing. Next-generation sequencing (NGS) has become an established approach for detecting …
View article: Gene actionability according to the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) in No Specific Molecular Profile (NSMP) endometrial cancer
Gene actionability according to the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) in No Specific Molecular Profile (NSMP) endometrial cancer Open
View article: Network analysis of NRG1 variants of uncertain significance (VUSes) in advanced non-small-cell lung cancer and their prognostic role in EGFR-mutant patients treated with first-line osimertinib
Network analysis of NRG1 variants of uncertain significance (VUSes) in advanced non-small-cell lung cancer and their prognostic role in EGFR-mutant patients treated with first-line osimertinib Open
Although retrospective, these data support the hypothesis that NRG1 VUSes are frequently associated with poor prognosis and other oncogene alterations. In EGFR M+ patients treated with osimertinib, concurrent NRG1 alterations were an indep…
View article: A comparative analysis of tumor markers reveals EDA fibronectin as a promising target in high-grade serous ovarian cancer
A comparative analysis of tumor markers reveals EDA fibronectin as a promising target in high-grade serous ovarian cancer Open
View article: Image-guided real-time optical biopsy in oncologic surgery: a systematic review of the role of confocal microscopy in the era of digital surgery
Image-guided real-time optical biopsy in oncologic surgery: a systematic review of the role of confocal microscopy in the era of digital surgery Open
Confocal microscopy (CM) is rapidly emerging as a key imaging technology within the evolving paradigm of digital surgery, offering real-time, high-resolution visualization of tissue microarchitecture. Its diverse modalities-including confo…
View article: Focal lymphovascular space invasion: Friend or foe? A large retrospective analysis on stage I endometrioid endometrial carcinomas
Focal lymphovascular space invasion: Friend or foe? A large retrospective analysis on stage I endometrioid endometrial carcinomas Open
In stage I endometrioid ECs, LVSI-focal was not associated with reduced oncologic outcomes compared to LVSI-negative. In contrast, LVSI-substantial was associated with aggressive clinicopathologic and molecular features and behaved as an i…
View article: Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients
Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients Open
Purpose HGSOC patients with BRCA1/2 mutations show HRD and PARPi sensitivity. Notably, HRD and PARPi response can occur without BRCA mutations, suggesting other factors are involved. Loss of CCDC6 function can lead to HRD and PARPi sensiti…
View article: Detection of Clinically Significant BRCA Large Genomic Rearrangements in FFPE Ovarian Cancer Samples: A Comparative NGS Study
Detection of Clinically Significant BRCA Large Genomic Rearrangements in FFPE Ovarian Cancer Samples: A Comparative NGS Study Open
Background: Copy number variations (CNVs), also referred to as large genomic rearrangements (LGRs), represent a crucial component of BRCA1/2 (BRCA) testing. Next-generation sequencing (NGS) has become an established approach for detecting …
View article: Varan: a tool for managing mutational data and creating cancer studies in cBioPortal
Varan: a tool for managing mutational data and creating cancer studies in cBioPortal Open
cBioPortal has established itself as a widely used platform for exploring and visualizing multidimensional cancer data. Additionally, users have the option to upload their own cancer study for a comprehensive experience. However, the uploa…
View article: An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training
An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training Open
View article: Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer
Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer Open
Microsatellite instability and mismatch repair deficiency are important biomarkers in colorectal and endometrial cancers, helping guide diagnosis, prognosis, and treatment decisions, particularly for immunotherapy. Mismatch repair status i…
View article: Response to letter re: Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study
Response to letter re: Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study Open
View article: Response to letter re: Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study
Response to letter re: Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study Open
View article: Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine
Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine Open
Purpose of Review Renal cell carcinoma (RCC) is a prevalent and increasingly diagnosed malignancy associated with high mortality and recurrence rates. Traditional diagnostic and therapeutic approaches have limitations due to the disease’s …
View article: 141P Preliminary results of a comprehensive genome profiling in patients treated with Cyclin-dependent Kinase 4/6 inhibitors (CDK4/6i) plus endocrine therapy (ET) as first-line treatment for advanced breast cancer (ABC)
141P Preliminary results of a comprehensive genome profiling in patients treated with Cyclin-dependent Kinase 4/6 inhibitors (CDK4/6i) plus endocrine therapy (ET) as first-line treatment for advanced breast cancer (ABC) Open
View article: Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study
Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study Open
View article: Are all mismatch repair deficient endometrial cancers created equal? A large, retrospective, tertiary center experience
Are all mismatch repair deficient endometrial cancers created equal? A large, retrospective, tertiary center experience Open
View article: <i>POLE</i> mutations in endometrial carcinoma: Clinical and genomic landscape from a large prospective single‐center cohort
<i>POLE</i> mutations in endometrial carcinoma: Clinical and genomic landscape from a large prospective single‐center cohort Open
Background To date, 11 DNA polymerase epsilon ( POLE ) pathogenic variants have been declared “hotspot” mutations. Patients with endometrial cancer (EC) characterized by POLE hotspot mutations ( POLE mut) have exceptional survival outcomes…
View article: Focal Lymphovascular Space Invasion: Friend or Foe? A Large Retrospective Analysis on Stage I Endometrioid Endometrial Carcinomas
Focal Lymphovascular Space Invasion: Friend or Foe? A Large Retrospective Analysis on Stage I Endometrioid Endometrial Carcinomas Open
View article: Characterization of shared neoantigens landscape in Mismatch Repair Deficient Endometrial Cancer
Characterization of shared neoantigens landscape in Mismatch Repair Deficient Endometrial Cancer Open
View article: Impact of Comprehensive Genome Profiling on the Management of Advanced Non–Small Cell Lung Cancer: Preliminary Results From the Lung Cancer Cohort of the FPG500 Program
Impact of Comprehensive Genome Profiling on the Management of Advanced Non–Small Cell Lung Cancer: Preliminary Results From the Lung Cancer Cohort of the FPG500 Program Open
PURPOSE The clinical and research FPG500 program (ClinicalTrials.gov identifier: NCT06020625 ) is currently ongoing at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS to tailor matched targeted therapies (MTTs) according to…
View article: Germline reflex <i>BRCA1/2</i> testing following tumor-only comprehensive genomic profiling: why, when, and how
Germline reflex <i>BRCA1/2</i> testing following tumor-only comprehensive genomic profiling: why, when, and how Open
The majority of tumor comprehensive genomic profiling (CGP) currently does not include a matched normal control. The use of a tumor-only CGP approach needs the development of a strategy to refine germline pathogenic/likely pathogenic varia…
View article: Future of sentinel node biopsy in ovarian cancer
Future of sentinel node biopsy in ovarian cancer Open
Purpose of review The rationale on the use of sentinel lymph node (SLN) biopsy in the surgical staging of apparent early-stage ovarian cancer (OC) is supported by the fact that diagnostic and prognostic role of systematic staging lymphaden…
View article: Identifying New Therapeutic Targets in Epithelial Ovarian Cancer
Identifying New Therapeutic Targets in Epithelial Ovarian Cancer Open
Background Ovarian cancer is a significant health concern, necessitating the identification of potential diagnostic markers and novel therapeutic targets. This study presents, to the best of our knowledge, the first comparative immunohisto…
View article: Characterization of shared neoantigens in Endometrial Cancer with Microsatellite Instability
Characterization of shared neoantigens in Endometrial Cancer with Microsatellite Instability Open
Endometrial cancer (EC) with microsatellite instability (MSI) are characterized by the accumulation of insertions/deletions at microsatellite sites, mainly mononucleotide repeats (MNRs). These MSI-related mutations lead to the synthesis of…
View article: 42MO Interpreting somatic POLE mutations in endometrial cancer emerging from comprehensive genomic profiling
42MO Interpreting somatic POLE mutations in endometrial cancer emerging from comprehensive genomic profiling Open
View article: 60P Exploration of homologous recombination deficiency testing in ovarian cancer: Insight from an Italian referral center
60P Exploration of homologous recombination deficiency testing in ovarian cancer: Insight from an Italian referral center Open
View article: 20P Unexpected germline pathogenic variants in gynaecologic cancers identified through a comprehensive cancer genome profiling programme
20P Unexpected germline pathogenic variants in gynaecologic cancers identified through a comprehensive cancer genome profiling programme Open
There is a growing utilization of comprehensive cancer genome profiling (CGP) to assess patients' eligibility for target therapies. Potential pathogenic germline variants (PPGVs) may be identified via CGP. Large series indicate that PPGVs …
View article: 5P Ovarian cancer ESCAT gene actionability: Cinderella wears the gown
5P Ovarian cancer ESCAT gene actionability: Cinderella wears the gown Open
In recent years, the prognosis of several malignancies has been positively influenced by the introduction of target therapy. In this context, ovarian cancer (OC) has played a minor role and chemotherapy still represents the backbone of sta…