Camille Daviaud
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View article: 902 CD63 as a marker of T cell dysfunction and immune evasion in irradiated glioblastoma
902 CD63 as a marker of T cell dysfunction and immune evasion in irradiated glioblastoma Open
View article: 668 Fatty acid metabolism promotes innate immune evasion and resistance to immunotherapy in irradiated glioblastoma
668 Fatty acid metabolism promotes innate immune evasion and resistance to immunotherapy in irradiated glioblastoma Open
View article: RADIATION-INDUCED LIPID METABOLISM IMPAIRS INNATE IMMUNITY TO PROMOTE GLIOBLASTOMA IMMUNE EVASION
RADIATION-INDUCED LIPID METABOLISM IMPAIRS INNATE IMMUNITY TO PROMOTE GLIOBLASTOMA IMMUNE EVASION Open
AIMS Radiation therapy (RT) can trigger type I interferon (IFN-I) responses and anti-tumor immunity in various can- cers. However, glioblastoma inevitably recurs, suggesting RT does not generate a long-lasting immune response. This may be …
View article: 843 Targeting FASN prevents CD8+ T cell exhaustion in irradiated glioblastoma
843 Targeting FASN prevents CD8+ T cell exhaustion in irradiated glioblastoma Open
View article: 1358 Fatty acid metabolism limits type I interferon responses in irradiated glioblastoma
1358 Fatty acid metabolism limits type I interferon responses in irradiated glioblastoma Open
View article: 457 Targeting FASN sensitizes irradiated glioblastoma to immune checkpoint blockade
457 Targeting FASN sensitizes irradiated glioblastoma to immune checkpoint blockade Open
Background Radiation therapy (RT), the standard-of-care for glioblastoma, activates cancer cell-intrinsic type I interferon (IFN-I) responses and generates systemic immunity in multiple cancers. However, the combination of RT and immune ch…
View article: Supplementary Figures from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses
Supplementary Figures from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses Open
Supplementary Figures 1-4
View article: Data from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses
Data from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses Open
Focal radiotherapy can promote cross-presentation of tumor antigens to T cells, but by itself, it is insufficient to induce therapeutically effective T-cell responses. The common gamma-chain cytokine IL15 promotes and sustains the prolifer…
View article: Figure S1 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S1 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Gating strategy of intratumoral CD8+ T cells.
View article: Data from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Data from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Increased regulatory T cells (Treg) after radiotherapy have been reported, but the mechanisms of their induction remain incompletely understood. TGFβ is known to foster Treg differentiation within tumors and is activated following radiothe…
View article: Figure S4 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S4 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
INHBA expression correlates with the tumor-infiltrating Treg score in ER positive and negative breast cancer patients.
View article: Figure S3 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S3 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Characterization of Inhba knock-in in TSA cell.
View article: Supplementary Figure Legend from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Supplementary Figure Legend from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Supplementary Figure Legend
View article: Figure S1 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S1 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Gating strategy of intratumoral CD8+ T cells.
View article: Data from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses
Data from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses Open
Focal radiotherapy can promote cross-presentation of tumor antigens to T cells, but by itself, it is insufficient to induce therapeutically effective T-cell responses. The common gamma-chain cytokine IL15 promotes and sustains the prolifer…
View article: Supplementary Figures from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses
Supplementary Figures from Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses Open
Supplementary Figures 1-4
View article: Figure S3 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S3 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Characterization of Inhba knock-in in TSA cell.
View article: Figure S2 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S2 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Characterization of Inhba knockdown in 4T1 cells.
View article: Figure S4 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S4 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
INHBA expression correlates with the tumor-infiltrating Treg score in ER positive and negative breast cancer patients.
View article: Supplementary Figure Legend from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Supplementary Figure Legend from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Supplementary Figure Legend
View article: Figure S2 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Figure S2 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Characterization of Inhba knockdown in 4T1 cells.
View article: Data from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
Data from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open
Increased regulatory T cells (Treg) after radiotherapy have been reported, but the mechanisms of their induction remain incompletely understood. TGFβ is known to foster Treg differentiation within tumors and is activated following radiothe…
View article: 447 Dual targeting of PD-1 and CTLA-4 synergizes with focal radiation to durably increase survival against glioblastoma
447 Dual targeting of PD-1 and CTLA-4 synergizes with focal radiation to durably increase survival against glioblastoma Open
Background The immunogenic role of ionizing radiation raised the use of radiation therapy (RT) as an immune adjuvant in multiple cancers. However, clinical trials testing RT and immune checkpoint blockers (ICB) combination failed to improv…
View article: TMET-10. FATTY ACID METABOLISM REGULATES IMMUNE REACTIVITY OF IRRADIATED GLIOBLASTOMA
TMET-10. FATTY ACID METABOLISM REGULATES IMMUNE REACTIVITY OF IRRADIATED GLIOBLASTOMA Open
Radiation therapy (RT) is the standard-of-care for glioblastoma (GBM) and is the only treatment for inoperable brain tumors. In multiple cancer, RT stimulates anti-tumor immunity by at least activating cancer cell-intrinsic type I interfer…
View article: Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma
Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma Open
Purpose Radiation therapy (RT) is essential for the management of glioblastoma (GBM). However, GBM frequently relapses within the irradiated margins, thus suggesting that RT might stimulate mechanisms of resistance that limits its efficacy…
View article: TAMI-65. FASN-MEDIATED LIPID SYNTHESIS HAMPERS ANTI-CANCER IMMUNITY OF GLIOBLASTOMA
TAMI-65. FASN-MEDIATED LIPID SYNTHESIS HAMPERS ANTI-CANCER IMMUNITY OF GLIOBLASTOMA Open
Glioblastoma (GBM) is the most aggressive type of primary brain tumor in adults. Radiation therapy (RT) is an essential modality for GBM treatment and is recognized to stimulate anti-cancer immunity by at least generating type I interferon…
View article: 905 FASN prevents immunogenicity of irradiated glioblastoma by inhibiting ER stress
905 FASN prevents immunogenicity of irradiated glioblastoma by inhibiting ER stress Open
Background Glioblastoma (GBM) is the most aggressive and incurable adult brain tumor. Radiation therapy (RT) is an essential modality for GBM treatment and is recognized to stimulate anti-tumor immunity by inducing immunogenic cell death (…
View article: Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma Open
Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improv…
View article: DDRE-26. THE IMMUNO-METABOLIC ENZYME FASN PREVENTS CANCER-CELL INTRINSIC TYPE I INTERFERON RESPONSES IN GLIOBLASTOMA
DDRE-26. THE IMMUNO-METABOLIC ENZYME FASN PREVENTS CANCER-CELL INTRINSIC TYPE I INTERFERON RESPONSES IN GLIOBLASTOMA Open
Glioblastoma (GBM) is a devastating primary brain cancer with a median survival of 11–15 months. Radiation therapy (RT), the standard of care for GBM, can generate type I interferon responses (IFN-I) to jumpstart antitumor immunity. Howeve…
View article: Activin A backs-up TGF-ß to promote regulatory T cells
Activin A backs-up TGF-ß to promote regulatory T cells Open
The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune response…