Camille Goemans
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View article: Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis
Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis Open
Dental pulp responses to dental decay, the most prevalent chronic disease worldwide, involve remodeling processes comparable to those observed in other human diseases. By combining volumetric imaging and single‐cell analysis at various sta…
View article: Mining the gut microbiota for defluorination activity
Mining the gut microbiota for defluorination activity Open
The gut microbiota harbors a vast array of enzymes, many with unknown functions. In a recent study, Probst et al. mined this ecosystem to identify potential defluorinating enzymes. Combining molecular dynamics, alanine scanning, and machin…
View article: Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression
Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression Open
Dental pulp responses to dental decay, the most prevalent chronic disease worldwide, involve remodeling processes similar to those observed in other human pathological conditions. By integrating volumetric imaging and single-cell analysis …
View article: Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics Open
By acquiring or evolving resistance to one antibiotic, bacteria can become resistant to a second one, due to shared underlying mechanisms. This is called cross-resistance (XR) and further limits therapeutic choices. The opposite scenario, …
View article: The killing of human gut commensal<i>E. coli</i>ED1a by tetracycline is associated with severe ribosome dysfunction
The killing of human gut commensal<i>E. coli</i>ED1a by tetracycline is associated with severe ribosome dysfunction Open
SUMMARY Ribosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such an…
View article: A molecular plugin rescues GroEL/ES substrates from pre-folding oxidation
A molecular plugin rescues GroEL/ES substrates from pre-folding oxidation Open
SUMMARY Hsp60 chaperonins and their Hsp10 cofactors assist protein folding in all living cells, constituting the paradigmatic example of molecular chaperones. Despite extensive investigations of their structure and mechanism, crucial quest…
View article: How the assembly and protection of the bacterial cell envelope depend on cysteine residues
How the assembly and protection of the bacterial cell envelope depend on cysteine residues Open
The cell envelope of Gram-negative bacteria is a multilayered structure essential for bacterial viability; the peptidoglycan cell wall provides shape and osmotic protection to the cell, and the outer membrane serves as a permeability barri…
View article: Data for "Unravelling the collateral damage of antibiotics on gut bacteria"
Data for "Unravelling the collateral damage of antibiotics on gut bacteria" Open
This dataset encompasses all data needed to reproduce the analyses presented in the paper "Unravelling the collateral damage of antibiotics on gut bacteria", available here: https://doi.org/10.1038/s41586-021-03986-2 You can also check the…
View article: Dissecting the collateral damage of antibiotics on gut microbes
Dissecting the collateral damage of antibiotics on gut microbes Open
Antibiotics are used for fighting pathogens, but also target our commensal bacteria as a side effect, disturbing the gut microbiota composition and causing dysbiosis and disease 1-3 . Despite this well-known collateral damage, the activity…
View article: Data for "Unravelling the collateral damage of antibiotics on gut bacteria"
Data for "Unravelling the collateral damage of antibiotics on gut bacteria" Open
This dataset encompasses all data needed to reproduce the analyses presented in the paper "Unravelling the collateral damage of antibiotics on gut bacteria", available here: https://doi.org/10.1038/s41586-021-03986-2 You can also check the…
View article: Faculty Opinions recommendation of Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA.
Faculty Opinions recommendation of Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA. Open
The b-barrel assembly machine (Bam) complex in Gram-negative bacteria and its counterparts in mitochondria and chloroplasts fold and insert outer membrane b-barrel proteins.BamA, an essential component of the complex, is itself a b-barrel …
View article: Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid
Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid Open
Hypochlorous acid (HOCl; bleach) is a powerful weapon used by our immune system to eliminate invading bacteria. Yet the way HOCl actually kills bacteria and how they defend themselves from its oxidative action have only started to be uncov…
View article: Faculty Opinions recommendation of Protein quality control under oxidative stress conditions.
Faculty Opinions recommendation of Protein quality control under oxidative stress conditions. Open
Accumulation of reactive oxygen and chlorine species (RO/CS) is generally regarded to be a toxic and highly undesirable event, which serves as contributing factor in aging and many age-related diseases.However, it is also put to excellent …
View article: The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species
The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species Open
How proteins are protected from stress-induced aggregation is a crucial question in biology and a long-standing mystery. While a long series of landmark studies have provided important contributions to our current understanding of the prot…