Camille Roquencourt
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View article: Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus
Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus Open
Aim The role of somatostatin (SST) in the modulation of cholinergic neurotransmission has not been explored previously in human bronchi. We investigated the effects of SST, selective agonists of the five SST receptors SSTR, and octreotide …
View article: IFNγ in human sepsis: a scoping review
IFNγ in human sepsis: a scoping review Open
Background The cytokine IFNγ is released primarily by lymphocytes to initiate and orchestrate immune responses in a broad range of target cells. Whereas immune cells release inflammatory mediators and initiate antimicrobial responses when …
View article: Clinical value of circulating bioactive adrenomedullin for prediction of outcome and hydrocortisone response in sepsis patients—a post-hoc analysis of the HYPRESS trial
Clinical value of circulating bioactive adrenomedullin for prediction of outcome and hydrocortisone response in sepsis patients—a post-hoc analysis of the HYPRESS trial Open
Purpose Sepsis requires stratification for host-directed therapies through the discovery of adequate biomarkers enabling prediction of outcomes and treatment responses. Adrenomedullin has previously demonstrated potential for prognostic en…
View article: Short-term modification of breathprint by Elexacaftor/Tezacaftor/Ivacaftor in a paediatric cohort
Short-term modification of breathprint by Elexacaftor/Tezacaftor/Ivacaftor in a paediatric cohort Open
View article: Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research
Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research Open
View article: Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: an open-label proof-of-concept study
Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: an open-label proof-of-concept study Open
Background The combination of CFTR modulators ivacaftor/tezacaftor/elexacaftor (ETI) achieves unprecedented improvements in clinical symptoms and respiratory function of people with cystic fibrosis. Yet, evaluation is difficult in people w…
View article: Therapeutic drug monitoring of corticosteroids/β2-agonists in the hair of patients with asthma: an open-label feasibility study
Therapeutic drug monitoring of corticosteroids/β2-agonists in the hair of patients with asthma: an open-label feasibility study Open
Background: Although adherence to inhaled medication is critically important for treatment efficiency, around half of patients taking these drugs are non-adherent or make critical errors when using their delivery device. Segmental hair ana…
View article: A benchmark study of data normalisation methods for PTR-TOF-MS exhaled breath metabolomics
A benchmark study of data normalisation methods for PTR-TOF-MS exhaled breath metabolomics Open
Volatilomics is the branch of metabolomics dedicated to the analysis of volatile organic compounds in exhaled breath for medical diagnostic or therapeutic monitoring purposes. Real-time mass spectrometry (MS) technologies such as proton tr…
View article: Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19
Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19 Open
Background Although rapid screening for and diagnosis of coronavirus disease 2019 (COVID-19) are still urgently needed, most current testing methods are long, costly or poorly specific. The objective of the present study was to determine w…
View article: Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19
Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19 Open
Background Although rapid screening for and diagnosis of COVID-19 are still urgently needed, most current testing methods are either long, costly, and/or poorly specific. The objective of the present study was to determine whether or not a…
View article: A benchmark study of data normalisation methods for PTR-TOF-MS exhaled breath metabolomics
A benchmark study of data normalisation methods for PTR-TOF-MS exhaled breath metabolomics Open
Background Volatilomics is the branch of metabolomics dedicated to the analysis of volatile organic compounds (VOCs) in exhaled breath for medical diagnostic or therapeutic monitoring purposes. Real-time mass spectrometry technologies such…
View article: Traitement du signal et analyse des données PTR-TOF-MS de l'air expiré pour la découverte de biomarqueurs
Traitement du signal et analyse des données PTR-TOF-MS de l'air expiré pour la découverte de biomarqueurs Open
The analysis of Volatile Organic Compounds (VOCs) in exhaled breath is a promising non-invasive approach in medicine for early diagnosis, phenotyping, disease and treatment monitoring and large-scale screening. Proton Transfer Reaction Tim…
View article: ptairMS: real-time processing and analysis of PTR-TOF-MS data for biomarker discovery in exhaled breath
ptairMS: real-time processing and analysis of PTR-TOF-MS data for biomarker discovery in exhaled breath Open
Motivation Analysis of volatile organic compounds (VOCs) in exhaled breath by proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS) is of increasing interest for real-time, non-invasive diagnosis, phenotyping and therapeut…
View article: Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study
Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study Open