Camille V. Chagneau
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View article: Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals Open
View article: Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria
Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria Open
CprA is a short‐chain dehydrogenase/reductase (SDR) that contributes to resistance against colistin and antimicrobial peptides. The cprA gene is conserved across Pseudomonas aeruginosa clades and its expression is directly regulated by the…
View article: Evaluation of several routine methods for fosfomycin and mecillinam susceptibility testing of Enterobacterales urine isolates
Evaluation of several routine methods for fosfomycin and mecillinam susceptibility testing of Enterobacterales urine isolates Open
Objectives Performance evaluation of routine laboratory methods to determine the susceptibility of Enterobacterales urinary isolates to fosfomycin (oral administration) and mecillinam. Methods We collected 347 Enterobacterales isolates fro…
View article: HlyF, an underestimated virulence factor of uropathogenic Escherichia coli
HlyF, an underestimated virulence factor of uropathogenic Escherichia coli Open
View article: Oxygen concentration modulates colibactin production
Oxygen concentration modulates colibactin production Open
Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is accumulating for an etiologic role of colibact…
View article: HlyF, an underestimated virulence factor of uropathogenic<i>Escherichia coli</i>
HlyF, an underestimated virulence factor of uropathogenic<i>Escherichia coli</i> Open
Urinary tract infections (UTIs) are predominantly caused by uropathogenic Escherichia coli (UPEC). By analysing a representative collection of UPEC strains from community-acquired infections, we showed that 20 % of these strains had the ab…
View article: Oxygen concentration modulates colibactin production
Oxygen concentration modulates colibactin production Open
Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is accumulating for an etiologic role of colibactin in colorect…
View article: Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli
Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli Open
Secondary metabolite expression is a widespread strategy among bacteria to improve their fitness in habitats where they constantly compete for resources with other bacteria. The production of secondary metabolites is associated with a meta…
View article: Etude de la colibactine dans les infections urinaires
Etude de la colibactine dans les infections urinaires Open
Urinary tract infections (UTIs) are among the most common community-acquired or nosocomial bacterial infections. They are most often caused by uropathogenic Escherichia coli (UPECs). We assembled a collection of UPECs from 223 patients suf…
View article: A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917
A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917 Open
Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human c…
View article: Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population
Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population Open
The pks island codes for the enzymes necessary for synthesis of the genotoxin colibactin, which contributes to the virulence of Escherichia coli strains and is suspected of promoting colorectal cancer. From a collection of 785 human and bo…
View article: Insights into the acquisition of the<i>pks</i>island and production of colibactin in the<i>Escherichia coli</i>population
Insights into the acquisition of the<i>pks</i>island and production of colibactin in the<i>Escherichia coli</i>population Open
The pks island codes for the enzymes necessary for synthesis of the genotoxin colibactin, which contributes to the virulence of Escherichia coli strains and is suspected of promoting colorectal cancer. From a collection of 785 human and bo…
View article: A toxic friend: Genotoxic and mutagenic activity of the probiotic strain<i>Escherichia coli</i>Nissle 1917
A toxic friend: Genotoxic and mutagenic activity of the probiotic strain<i>Escherichia coli</i>Nissle 1917 Open
The probiotic Escherichia coli strain Nissle 1917 (DSM 6601, Mutaflor), generally considered as beneficial and safe, has been used for a century to treat various intestinal diseases. However, Nissle 1917 hosts in its genome the pks pathoge…
View article: Uropathogenic E. coli induces DNA damage in the bladder
Uropathogenic E. coli induces DNA damage in the bladder Open
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the clea…
View article: The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin
The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin Open
Colibactin-producing E. coli induces DNA damage in eukaryotic cells and promotes tumor formation in mouse models of intestinal inflammation. Recent studies have provided strong evidence supporting the causative role of colibactin in human …
View article: Uropathogenic<i>E. coli</i>induces DNA damage in the bladder
Uropathogenic<i>E. coli</i>induces DNA damage in the bladder Open
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of a metabo…
View article: The synergistic triad between microcin, colibactin, and salmochelin gene clusters in uropathogenic Escherichia coli
The synergistic triad between microcin, colibactin, and salmochelin gene clusters in uropathogenic Escherichia coli Open
A functional synergy was previously demonstrated between microcin, salmochelin and colibactin islands in Escherichia coli strains from B2 phylogroup. We aimed to determine this association prevalence in uropathogenic E. coli, and whether i…
View article: The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin Open
Colibactin-producing Escherichia coli strains are associated with cancerous and precancerous colorectal tissues and are suspected of promoting colorectal carcinogenesis. In this study, we describe a new interplay between the synthesis of t…
View article: Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917
Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917 Open
Although Escherichia coli Nissle 1917 (EcN) has been used therapeutically for over a century, the determinants of its probiotic properties remain elusive. EcN produces two siderophore-microcins (Mcc) responsible for an antagonistic activit…
View article: Étude des métabolites liés à l’îlot pks chez les souches urinaires de Escherichia coli
Étude des métabolites liés à l’îlot pks chez les souches urinaires de Escherichia coli Open
Escherichia coli is the first cause of symptomatic urinary tract infections but can also be involved in asymptomatic bacteriuria. The genome of some urinary strains of E. coli harbors a pathogenicity island, named pks island. Transcriptomi…