Camillo Marra
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View article: Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease
Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease Open
This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient jo…
View article: The remote administration of the uniform data set neuropsychological test battery (I-UDSNB) Italian version: normative data
The remote administration of the uniform data set neuropsychological test battery (I-UDSNB) Italian version: normative data Open
The availability of remotely administered neuropsychological batteries is crucial to provide access to care in extraordinary situations, e.g., the recent pandemic, and for individuals with reduced mobility. Here we present the normative da…
View article: Establishing a Digitally Enabled Healthcare Framework for Enhanced Prevention, Risk Identification, and Relief for Dementia and Frailty
Establishing a Digitally Enabled Healthcare Framework for Enhanced Prevention, Risk Identification, and Relief for Dementia and Frailty Open
During the last decade, artificial intelligence (AI) has enabled key technological innovations within the modern dementia and frailty healthcare and prevention landscape. This has boosted the impact of technology in the clinical setting, e…
View article: Predicting Cognitive Decline in Parkinson’s Disease Using Artificial Neural Networks: An Explainable AI Approach
Predicting Cognitive Decline in Parkinson’s Disease Using Artificial Neural Networks: An Explainable AI Approach Open
Background/Objectives: The study aims to identify key cognitive and non-cognitive variables (e.g., clinical, neuroimaging, and genetic data) predicting cognitive decline in Parkinson’s disease (PD) patients using machine learning applied t…
View article: International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative
International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative Open
BACKGROUND: Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for neurocognitive disorders in memory clinics. T…
View article: Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study
Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study Open
View article: The management of mild neurocognitive disorder in primary care: A Delphi consensus study
The management of mild neurocognitive disorder in primary care: A Delphi consensus study Open
Background Strategies to identify and treat mild neurocognitive disorder (mild NCD) are still unclear. Objective The detection and management of mild NCD are crucial to prevent or delay its progression to major NCD, and to help those affec…
View article: Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?
Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true? Open
In this "centenary" paper, an expert panel revisited Hans Berger's groundbreaking discovery of human restingstate electroencephalographic (rsEEG) alpha rhythms (8-12 Hz) in 1924, his foresight of substantial clinical applications in patien…
View article: Risk factors of dementia in a cohort of individuals with mild cognitive impairment in the Italian Interceptor project
Risk factors of dementia in a cohort of individuals with mild cognitive impairment in the Italian Interceptor project Open
Background The Italian Interceptor project is aimed at identifying a prodromal dementia phase and developing a nationwide organizational model. This study compares the sociodemographic and neuropsychological characteristics of mild cogniti…
View article: Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders
Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders Open
Background Functional cognitive disorder (FCD) poses a diagnostic challenge due to its resemblance to other neurocognitive disorders and limited biomarker accuracy. We aimed to develop a new diagnostic checklist to identify FCD versus othe…
View article: Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse® platform
Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse® platform Open
Our results suggest that plasma biomarkers, and especially Aβ42/Aβ40 ratio and pTau217, are promising candidates for the early detection of AD pathology.
View article: Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services
Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services Open
Background The Italian Fund for Alzheimer’s and other dementias approved in 2020 enabled the conducting of a survey in the Italian Centers for Cognitive Disorders and Dementias (CCDDs) to analyse the organization, the administrative featur…
View article: Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis
Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis Open
View article: Different Markers of Semantic–Lexical Impairment Allow One to Obtain Different Information on the Conversion from MCI to AD: A Narrative Review of an Ongoing Research Program
Different Markers of Semantic–Lexical Impairment Allow One to Obtain Different Information on the Conversion from MCI to AD: A Narrative Review of an Ongoing Research Program Open
Background: In this narrative review, we have surveyed results obtained from a research program dealing with the role of semantic memory disorders as a predictor of progression from mild cognitive impairment (MCI) to Alzheimer’s disease (A…
View article: The screening of cognitive impairment in the emergency department: A valuable clinical and epidemiological goal
The screening of cognitive impairment in the emergency department: A valuable clinical and epidemiological goal Open
View article: Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD
Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD Open
View article: Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario
Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario Open
The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared to manual recording. Nevertheless, the potential of the information contained within medical records remains large…
View article: The emerging role of the cerebellum in the affective theory of mind in the behavioral variant of frontotemporal dementia
The emerging role of the cerebellum in the affective theory of mind in the behavioral variant of frontotemporal dementia Open
We previously documented the relation between functional connectivity changes within mentalizing cerebello-cerebral networks and impaired performance on affective Theory of Mind (ToM) in patients with behavioral variant of Frontotemporal d…
View article: Development of a prediction model of conversion to Alzheimer’s disease in people with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project
Development of a prediction model of conversion to Alzheimer’s disease in people with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project Open
View article: Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer’s Disease
Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer’s Disease Open
View article: Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study
Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study Open
Background Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of cognitive specialists in the diagnosis and management of FCD in comparison wi…
View article: UNLOADING STRATEGIES IN ADVANCED HEART FAILURE: THE ROLE OF POINT–OF–CARE ULTRASOUND
UNLOADING STRATEGIES IN ADVANCED HEART FAILURE: THE ROLE OF POINT–OF–CARE ULTRASOUND Open
Patients with advanced heart failure (HF) exhibit repeated episodes of fluid retention (pulmonary and/or systemic congestion) and/or of reduced cardiac output at rest (peripheral hypoperfusion) requiring hospitalization along with diuretic…
View article: Correction to: A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device
Correction to: A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device Open
View article: Real-life management of patients with mild cognitive impairment: an Italian survey
Real-life management of patients with mild cognitive impairment: an Italian survey Open
Background Mild cognitive impairment (MCI) is a syndrome with heterogeneous underlying causes and different rates of disease progression, whose clinical heterogeneity leads to a wide variation in diagnostic and therapeutic approaches in cl…
View article: Performance of Fully-Automated High-Throughput Plasma Biomarker Assays for Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subjects
Performance of Fully-Automated High-Throughput Plasma Biomarker Assays for Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subjects Open
View article: Development of a prediction model of conversion to Alzheimer’s disease in subjects with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project
Development of a prediction model of conversion to Alzheimer’s disease in subjects with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project Open
Background In recent years, considerable efforts have been directed towards the research and development of disease-modifying therapies for dementia. These drugs focus on prodromal (Mild Cognitive Impairment, MCI) and/or early stages of Al…
View article: Intelligent digital tools for screening of brain connectivity and dementia risk estimation in people affected by mild cognitive impairment: the AI-Mind clinical study protocol
Intelligent digital tools for screening of brain connectivity and dementia risk estimation in people affected by mild cognitive impairment: the AI-Mind clinical study protocol Open
More than 10 million Europeans show signs of mild cognitive impairment (MCI), a transitional stage between normal brain aging and dementia stage memory disorder. The path MCI takes can be divergent; while some maintain stability or even re…
View article: AI-Mind: Revolutionizing Personalized Neurology Through Automated Diagnostics and Advanced Data Management
AI-Mind: Revolutionizing Personalized Neurology Through Automated Diagnostics and Advanced Data Management Open
View article: The Relationship between Language and Technology: How Screen Time Affects Language Development in Early Life—A Systematic Review
The Relationship between Language and Technology: How Screen Time Affects Language Development in Early Life—A Systematic Review Open
Screen time refers to the amount of time a child is exposed to a screen, that is, television, computer, smartphone, or any other digital medium. Prolonged screen time in the first years of life may affect a child’s cognitive abilities, esp…
View article: Medical Information Extraction with NLP-Powered QABots: a Real-World Scenario
Medical Information Extraction with NLP-Powered QABots: a Real-World Scenario Open
The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared with manual recording. Nevertheless, the potential of the information contained within medical records remains lar…