Camillo Palmieri
YOU?
Author Swipe
View article: Persistence of SARS‐CoV‐2 infection and viral <i>intra</i> ‐ and <i>inter</i> ‐host evolution in COVID‐19 hospitalized patients
Persistence of SARS‐CoV‐2 infection and viral <i>intra</i> ‐ and <i>inter</i> ‐host evolution in COVID‐19 hospitalized patients Open
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) persistence in COVID‐19 patients could play a key role in the emergence of variants of concern. The rapid intra ‐host evolution of SARS‐CoV‐2 may result in an increased transmiss…
View article: FABP5 is a Novel Key Player in Metabolic Modulation and NF-κB dependent Inflammation driving Malignant Pleural Mesothelioma
FABP5 is a Novel Key Player in Metabolic Modulation and NF-κB dependent Inflammation driving Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) poses a significant challenge in oncology due to its intricate molecular and metabolic landscape, chronic inflammation, and heightened oxidative stress, which contribute to its notorious resilience and …
View article: The biological variation of serum 1,25-dihydroxyvitamin D and parathyroid hormone, and plasma fibroblast growth factor 23 in healthy individuals
The biological variation of serum 1,25-dihydroxyvitamin D and parathyroid hormone, and plasma fibroblast growth factor 23 in healthy individuals Open
We report for the first time BV estimates for 1,25(OH)2D and enhance existing data about iFGF23-BV and PTH 1-84-BV through cutting-edge immunometric methods.
View article: Enhanced pro-apoptotic activity of rituximab through IBTK silencing in non-Hodgkin lymphoma B-cells
Enhanced pro-apoptotic activity of rituximab through IBTK silencing in non-Hodgkin lymphoma B-cells Open
Rituximab is a commonly used chemotherapeutic drug for patients with aggressive lymphomas, such as non-Hodgkin’s lymphoma (NHL). Currently, the combination of Rituximab and chemotherapy (R-CHOP) stands as the most prevalent first-line ther…
View article: The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection
The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection Open
Background The evolving variants of SARS-CoV-2 may escape immunity from prior infections or vaccinations. It’s vital to understand how immunity adapts to these changes. Both infection and mRNA vaccination induce T cells that target the Spi…
View article: Humoral and T-cell response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients: Correlations with DMTs and clinical variables
Humoral and T-cell response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients: Correlations with DMTs and clinical variables Open
Disease-modifying therapies (DMTs) can affect vaccine responses in individuals with multiple sclerosis (MS). We assessed the humoral and T-cell responses following SARS-CoV-2 mRNA vaccination in MS patients receiving various DMTs. We prosp…
View article: Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma
Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma Open
Introduction: The PD-1/PD-L1 axis is hijacked by lung adenocarcinoma (LUAD) cells to escape immune surveillance. PD-L1 expression in LUAD is affected, among others, by the metabolic trafficking between tumor cells and the tumor microenviro…
View article: Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 470K, Figure S1. UN1 mAb did not affect the proliferation rate, cell cycle, viability and apoptosis of HPB-ALL cells. Figure S2. The 2/165 phage clone and synthetic peptides do not inhibit the binding of mAb W6/32 to HPB-ALL cel…
View article: Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 37K
View article: Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
CD43 is a sialoglycosylated membrane protein that is involved in cell proliferation and differentiation. CD43 glycoforms that are recognized by the UN1 monoclonal antibody (mAb) were expressed in lymphoblastoid T-cell lines and solid tumor…
View article: Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 37K
View article: Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
CD43 is a sialoglycosylated membrane protein that is involved in cell proliferation and differentiation. CD43 glycoforms that are recognized by the UN1 monoclonal antibody (mAb) were expressed in lymphoblastoid T-cell lines and solid tumor…
View article: Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 470K, Figure S1. UN1 mAb did not affect the proliferation rate, cell cycle, viability and apoptosis of HPB-ALL cells. Figure S2. The 2/165 phage clone and synthetic peptides do not inhibit the binding of mAb W6/32 to HPB-ALL cel…
View article: Severe and mild-moderate SARS-CoV-2 vaccinated patients show different frequencies of IFNγ-releasing cells: An exploratory study
Severe and mild-moderate SARS-CoV-2 vaccinated patients show different frequencies of IFNγ-releasing cells: An exploratory study Open
Background Despite an apparent effective vaccination, some patients are admitted to the hospital after SARS-CoV-2 infection. The role of adaptive immunity in COVID-19 is growing; nonetheless, differences in the spike-specific immune respon…
View article: Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration
Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration Open
The H Ferritin subunit (FTH1), as well as regulating the homeostasis of intracellular iron, is involved in complex pathways that might promote or inhibit carcinogenesis. This function may be mediated by its ability to interact with differe…
View article: Spike-specific T-cell responses in patients with COVID-19 successfully treated with neutralizing monoclonal antibodies against SARS-CoV-2
Spike-specific T-cell responses in patients with COVID-19 successfully treated with neutralizing monoclonal antibodies against SARS-CoV-2 Open
The moAbs did not hinder short-term memory S-specific T-cell responses in the overall group of patients; however, differences among moAbs must be further investigated both in vaccinated and unvaccinated individuals.
View article: Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study
Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study Open
The management of prostate biopsy in men with clinical suspicion of prostate cancer has changed in the last few years, especially with the introduction of imaging techniques, to overcome the low efficacy of risk stratification based on PSA…
View article: FTH1 Pseudogenes in Cancer and Cell Metabolism
FTH1 Pseudogenes in Cancer and Cell Metabolism Open
Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseud…
View article: FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells
FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells Open
The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as we…
View article: Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy Open
The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entir…
View article: Insights into Thymus Development and Viral Thymic Infections
Insights into Thymus Development and Viral Thymic Infections Open
T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4+ or CD8+ single-positive (SP) T cells. Here, we briefly revi…
View article: Chemoresistance in H-Ferritin Silenced Cells: The Role of NF-κB
Chemoresistance in H-Ferritin Silenced Cells: The Role of NF-κB Open
Nuclear Factor-κB (NF-κB) is frequently activated in tumor cells contributing to aggressive tumor growth and resistance to chemotherapy. Here we demonstrate that Ferritin Heavy Chain (FHC) protein expression inversely correlates with NF-κB…
View article: Cross-talk among HMGA1 and FoxO1 in control of nuclear insulin signaling
Cross-talk among HMGA1 and FoxO1 in control of nuclear insulin signaling Open
As a mediator of insulin-regulated gene expression, the FoxO1 transcription factor represents a master regulator of liver glucose metabolism. We previously reported that the high-mobility group AT-hook 1 (HMGA1) protein, a molecular switch…
View article: The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells Open
PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer, displays tumor suppressor activity by negatively modulating several proteins involved in proliferating signals. Here, through a proteomic-based approach…
View article: IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells
IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells Open
The IBTK gene encodes the major protein isoform IBTKα that was recently characterized as substrate receptor of Cul3-dependent E3 ligase, regulating ubiquitination coupled to proteasomal degradation of Pdcd4, an inhibitor of translation. Du…