Camillo Rosano
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View article: Ap4A in Cancer: A Multifaceted Regulator and Emerging Therapeutic Target
Ap4A in Cancer: A Multifaceted Regulator and Emerging Therapeutic Target Open
Diadenosine polyphosphates, including diadenosine tetraphosphate (Ap4A), are ubiquitous nucleotides that are present across diverse life forms, gaining considerable interest due to their role as cellular signaling molecules. Ap4A, in parti…
View article: Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation
Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation Open
To further extend the structure – activity relationships (SARs) of the previously published ubiquitin‐specific protease 7 (USP‐7) inhibitor STIRUR‐41 , a small library of 5‐aminopyrazoles 1a–d and 2a–d is designed and synthesized. The chem…
View article: Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives Open
To further extend the structure‐activity relationships of previously reported antimalarial anilino‐pyrazoles VI , trisubstituted pyrazoles 13–15, and pyrimidines 16 and 17 are designed and synthesized. The novel derivatives are prepared th…
View article: Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative
Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative Open
Background: Carbazoles represent one of the most important classes of nitrogen-based tricyclic aromatic heterocycles and are present in natural sources and chemically obtained drugs. Recently, several research groups disclosed their large …
View article: A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease
A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease Open
Alexander disease (AxD) is a rare leukodystrophy caused by heterozygous mutations in the GFAP gene. To date, several in vitro and in vivo models have been generated in an attempt to unravel the main mechanisms underlying this complex disea…
View article: Design and synthesis of enantiopure NHC–silver(<scp>i</scp>) and NHC–gold(<scp>i</scp>) complexes with anticancer, anti-inflammatory and antioxidant properties
Design and synthesis of enantiopure NHC–silver(<span>i</span>) and NHC–gold(<span>i</span>) complexes with anticancer, anti-inflammatory and antioxidant properties Open
A new series of enantiopure N -heterocyclic carbene complexes of silver( i ) and gold( i ) was synthesized, characterized and studied for their anticancer, anti-inflammatory, and antioxidant properties. Results highlight the importance of …
View article: Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents
Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents Open
The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of microbial infections and cancer is an essential issue to be addressed. In this context, me…
View article: When Chirality Makes the Difference: The Case of Novel Enantiopure N-Heterocyclic Carbene–Gold and –Silver Complexes
When Chirality Makes the Difference: The Case of Novel Enantiopure N-Heterocyclic Carbene–Gold and –Silver Complexes Open
N-heterocyclic carbene (NHC)–gold and –silver complexes have attracted the interest of the scientific community because of their multiple applications and their versatility in being chemically modified in order to improve their biological …
View article: Epigenetic modulation of immune cells: Mechanisms and implications
Epigenetic modulation of immune cells: Mechanisms and implications Open
View article: Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties
Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties Open
View article: A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells
A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells Open
Cutaneous melanoma is the most dangerous and deadly form of human skin malignancy. Despite its rarity, it accounts for a staggering 80% of deaths attributed to cutaneous cancers overall. Moreover, its final stages often exhibit resistance …
View article: Investigations of Antioxidant and Anti-Cancer Activities of 5-Aminopyrazole Derivatives
Investigations of Antioxidant and Anti-Cancer Activities of 5-Aminopyrazole Derivatives Open
To further extend the structure-activity relationships (SARs) of 5-aminopyrazoles (5APs) and identify novel compounds able to interfere with inflammation, oxidative stress, and tumorigenesis, 5APs 1–4 have been designed and prepared. Some …
View article: Structure–Activity Relationship Studies on Highly Functionalized Pyrazole Hydrazones and Amides as Antiproliferative and Antioxidant Agents
Structure–Activity Relationship Studies on Highly Functionalized Pyrazole Hydrazones and Amides as Antiproliferative and Antioxidant Agents Open
Aminopyrazoles represent interesting structures in medicinal chemistry, and several derivatives showed biological activity in different therapeutic areas. Previously reported 5-aminopyrazolyl acylhydrazones and amides showed relevant antio…
View article: A Comprehensive Review on the State of the Art of Breast Cancers inItaly
A Comprehensive Review on the State of the Art of Breast Cancers inItaly Open
Breast cancer (BC) currently represents one of the most prevalent cancers among women worldwide and the leading cause of cancer death among women, also negatively affecting the quality of life (QoL) in patients. Over the past two decades, …
View article: Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology
Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology Open
Background and purpose: Lung cancer is the leading cause of death in both men and women, constituting a major public health problem worldwide. Non-small-cell lung cancer accounts for 85%–90% of all lung cancers. We propose a compound that …
View article: Design, Synthesis and Biological Evaluation of Multitarget Hybrid Molecules Containing Nhc-Au(I) Complexes and Carbazole Moieties
Design, Synthesis and Biological Evaluation of Multitarget Hybrid Molecules Containing Nhc-Au(I) Complexes and Carbazole Moieties Open
View article: A Multi-Omics Approach Reveals Impaired Lipid Metabolism and Oxidative Stress in a Zebrafish Model of Alexander Disease
A Multi-Omics Approach Reveals Impaired Lipid Metabolism and Oxidative Stress in a Zebrafish Model of Alexander Disease Open
View article: Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del‐CFTR
Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del‐CFTR Open
Cystic fibrosis is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In the search of novel series of CFTR modulators, a library of mono and diacyl thioureas were prepared by s…
View article: In Tandem Intragenic Duplication of Doublesex and Mab-3-Related Transcription Factor 1 (DMRT1) in an SRY-Negative Boy with a 46,XX Disorder of Sex Development
In Tandem Intragenic Duplication of Doublesex and Mab-3-Related Transcription Factor 1 (DMRT1) in an SRY-Negative Boy with a 46,XX Disorder of Sex Development Open
Disorders of sexual development (DSDs) encompass a group of congenital conditions associated with atypical development of internal and external genital structures. Among those with DSDs are 46,XX males, whose condition mainly arises due to…
View article: Micronucleus Induction in Vicia faba Root Tips by Crude Oil-Polluted Soil from Ecuadorian Amazon
Micronucleus Induction in Vicia faba Root Tips by Crude Oil-Polluted Soil from Ecuadorian Amazon Open
In the past four decades, the Amazon rainforest has emerged as a crucial zone for crude oil extraction in the South American region. In the Ecuadorian Amazon rainforest, hydrocarbon blocks (called “bloques”) cover vast zones, including agr…
View article: NHC-Ag(I) and NHC-Au(I) Complexes with <i>N</i>-Boc-Protected α-Amino Acidate Counterions Powerfully Affect the Growth of MDA-MB-231 Cells
NHC-Ag(I) and NHC-Au(I) Complexes with <i>N</i>-Boc-Protected α-Amino Acidate Counterions Powerfully Affect the Growth of MDA-MB-231 Cells Open
N-Heterocyclic carbene (NHC) metal complexes are attracting scientists' interest as an alluring class of metallodrugs. Indeed, the versatile functionalization of NHC ligands makes them optimal scaffolds to be developed in medicinal …
View article: Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic
Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic Open
Antibacterial resistance is a renewed public health plague in modern times, and the COVID-19 pandemic has rekindled this problem. Changes in antibiotic prescribing behavior, misinformation, financial hardship, environmental impact, and gov…
View article: Novel 5-aminopyrazoles endowed with anti-angiogenetic properties: Design, synthesis and biological evaluation
Novel 5-aminopyrazoles endowed with anti-angiogenetic properties: Design, synthesis and biological evaluation Open
View article: Development of 1‐(2‐aminophenyl)pyrrole‐based amides acting as human topoisomerase I inhibitors
Development of 1‐(2‐aminophenyl)pyrrole‐based amides acting as human topoisomerase I inhibitors Open
Topoisomerases are ubiquitous enzymes in the human body, particularly involved in cancer development and progression. Topoisomerase I (topoI) performs DNA relaxation reactions by “controlled rotation” rather than by “strand passage.” The i…
View article: Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole Hybrids as Human Topoisomerases Inhibitors
Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole Hybrids as Human Topoisomerases Inhibitors Open
Cancer is a complex and heterogeneous disease and is still one of the leading causes of morbidity and mortality worldwide, mostly as the population ages. Despite the encouraging advances made over the years in chemotherapy, the development…
View article: Insights into the Pharmacological Activity of the Imidazo−Pyrazole Scaffold
Insights into the Pharmacological Activity of the Imidazo−Pyrazole Scaffold Open
In previous studies, we synthesized different imidazo−pyrazoles 1 and 2 with interesting anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure‐activity relationships of imidazo−pyrazole scaffold and …
View article: 5,8-Dimethyl-9H-carbazole Derivatives Blocking hTopo I Activity and Actin Dynamics
5,8-Dimethyl-9H-carbazole Derivatives Blocking hTopo I Activity and Actin Dynamics Open
Over the years, carbazoles have been largely studied for their numerous biological properties, including antibacterial, antimalarial, antioxidant, antidiabetic, neuroprotective, anticancer, and many more. Some of them have gained great int…
View article: Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities
Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities Open
Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxida…
View article: Regioselective Synthesis, Structural Characterization, and Antiproliferative Activity of Novel Tetra-Substituted Phenylaminopyrazole Derivatives
Regioselective Synthesis, Structural Characterization, and Antiproliferative Activity of Novel Tetra-Substituted Phenylaminopyrazole Derivatives Open
A small library of highly functionalized phenylaminopyrazoles, bearing different substituents at position 1, 3, and 4 of the pyrazole ring, was prepared by the one-pot condensation of active methylene reagents, phenylisothiocyanate, and su…
View article: Exploring the anticancer and antioxidant properties of <i>Vicia faba</i> L. pods extracts, a promising source of nutraceuticals
Exploring the anticancer and antioxidant properties of <i>Vicia faba</i> L. pods extracts, a promising source of nutraceuticals Open
Background Pulse crops are considered the major sources of proteins, dietary fiber, micronutrients, and bioactive phytochemicals. Among the numerous pulse crops, broad beans ( Vicia faba L.) have received particular attention due to their …