Xiaocan Lei
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View article: Nicotinamide mononucleotide treatment improves spermatogenesis in obese mice by reducing lysine acetylation of lactate dehydrogenase C
Nicotinamide mononucleotide treatment improves spermatogenesis in obese mice by reducing lysine acetylation of lactate dehydrogenase C Open
Obesity is associated with impaired spermatogenesis and decreased sperm quality, in part through reducing Sertoli cells (SCs) lactate and nicotinamide adenine dinucleotide (NAD+) production. It is not known whether nicotinamide …
View article: Efficacy of dietary supplements as an adjunctive therapy for polycystic ovary syndrome: an umbrella meta-analysis
Efficacy of dietary supplements as an adjunctive therapy for polycystic ovary syndrome: an umbrella meta-analysis Open
Introduction Polycystic ovary syndrome (PCOS) affects 5–15% of reproductive-aged women and involves significant metabolic dysregulation, for which nutritional interventions show therapeutic potential. Methods: This umbrella meta-analysis s…
View article: Efficacy of inositol supplementation in the prevention and treatment of gestational diabetes mellitus: A meta-analysis
Efficacy of inositol supplementation in the prevention and treatment of gestational diabetes mellitus: A meta-analysis Open
BACKGROUND Gestational diabetes mellitus (GDM) poses a substantial health risk during pregnancy. However, the role of myo-inositol (MI) in GDM prevention and management remains controversial due to conflicting evidence and methodological l…
View article: Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration
Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration Open
Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative me…
View article: The effects of inhibiting IRE1α on the viability of ovarian granulosa cells
The effects of inhibiting IRE1α on the viability of ovarian granulosa cells Open
IRE1α, a type I transmembrane protein characterized by a cytoplasmic serine/threonine kinase domain, is related to ER stress and ER function maintenance. In this study, 4µ8c, a highly effective selective inhibitor of IRE1α RNase, and APY29…
View article: Correction: Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA
Correction: Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA Open
View article: The landscape of cell regulatory and communication networks in the human dental follicle
The landscape of cell regulatory and communication networks in the human dental follicle Open
Introduction The dental follicle localizes the surrounding enamel organ and dental papilla of the developing tooth germ during the embryonic stage. It can differentiate and develop to form the periodontal ligament, cementum, and alveolar b…
View article: Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS
Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS Open
MV improves PCOS by reducing pyroptosis and insulin resistance, enhancing insulin sensitivity, and promoting estrogen synthesis, thereby restoring granulosa cell function and follicular development.
View article: Inhibition of PGK1 acetylation by NMN improves the mechanism of action of support cell function in obese mice
Inhibition of PGK1 acetylation by NMN improves the mechanism of action of support cell function in obese mice Open
View article: Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells
Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells Open
NMN improves CTX-induced POI by inhibiting NLRP3-mediated pyroptosis, providing a new therapeutic strategy and drug target for clinical POI patients.
View article: The effects of inhibiting IRE1α on the proliferation of ovarian granulosa cells
The effects of inhibiting IRE1α on the proliferation of ovarian granulosa cells Open
IRE1α, a type I transmembrane protein characterized by a cytoplasmic serine/threonine kinase domain, is related to ER stress and ER function maintenance. In this study, 4µ8c, a highly effective selective inhibitor of IRE1α RNase, and APY29…
View article: Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA
Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA Open
The findings of this study show that miR-34a-5p mediates GC apoptosis in PCOS by targeting LDHA and inhibiting glycolysis, suggesting its crucial role in PCOS pathophysiology, and offering potential therapeutic targets for improving follic…
View article: MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis
MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis Open
Aim This study systematically evaluated the potential efficacy of serum matrix metalloproteinase-9 (MMP-9) concentration as a diagnostic marker for endometriosis through meta-analysis. Early and accurate diagnosis of endometriosis, a commo…
View article: The mechanism of NF-κB-TERT feedback regulation of granulosa cell apoptosis in PCOS rats
The mechanism of NF-κB-TERT feedback regulation of granulosa cell apoptosis in PCOS rats Open
Patients with Polycystic ovary syndrome (PCOS) have chronic low-grade ovarian inflammation. Inflammation can cause telomere dysfunction, and telomere and telomerase complex are also involved in regulating inflammation. However, the specifi…
View article: Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway
Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway Open
Radiotherapy, a common cancer treatment, leads to infertility in male cancer survivors, particularly young and middle-aged patients. Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD +), pl…
View article: Pyrroloquinoline quinone activates lactate production and inhibits NLRP3 to improve the apoptosis of granulosa cells in POI rats
Pyrroloquinoline quinone activates lactate production and inhibits NLRP3 to improve the apoptosis of granulosa cells in POI rats Open
Chemotherapy-induced premature ovarian insufficiency (POI) is an extreme form of reproductive aging in women, while the inflammatory factors manifest a vital cause of ovarian aging and serve as a research hotspot. However, there is still n…
View article: A Bibliometric Analysis of Global Research Trends in Polycystic Ovary Syndrome and Metformin
A Bibliometric Analysis of Global Research Trends in Polycystic Ovary Syndrome and Metformin Open
Background: Polycystic ovary syndrome (PCOS) stands as one of the most prevalent endocrine disorders affecting women of reproductive age. Despite being recognized for decades, numerous unresolved issues persist regarding its impact on repr…
View article: The mechanism of NF-κB-TERT feedback regulation of granulosa cell apoptosis in PCOS rats with follicular development disorder
The mechanism of NF-κB-TERT feedback regulation of granulosa cell apoptosis in PCOS rats with follicular development disorder Open
Background The aim of this study is to investigate whether TERT mediates chronic inflammation and induces granulosa cell apoptosis by participating in the regulation of the NF-κB signaling pathway. Methods Letrozole combined with high-fat …
View article: Mapping the Landscape of Obesity Effects on Male Reproductive Function:A Bibliometric Study
Mapping the Landscape of Obesity Effects on Male Reproductive Function:A Bibliometric Study Open
Background: Due to changes in lifestyle and dietary habits, the global population with obesity is increasing gradually, resulting in a significant rise in the number of individuals having obesity. Obesity is caused by an imbalance between …
View article: Icariosin Inhibition of Nlrp3 Mediated Leydig Cell Pyroptosis and Insulin Resistance Ameliorates Spermatogenesis Disorders in Obese Mice
Icariosin Inhibition of Nlrp3 Mediated Leydig Cell Pyroptosis and Insulin Resistance Ameliorates Spermatogenesis Disorders in Obese Mice Open
View article: Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice
Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice Open
Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testosterone (T) synthesis of obesi…
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View article: The regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in chronic inflammatory diseases
The regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in chronic inflammatory diseases Open
Inflammation is believed to play a role in the progression of numerous human diseases. Research has shown that inflammation and telomeres are involved in a feedback regulatory loop: inflammation increases the rate of telomere attrition, le…
View article: Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells Open
Scope Insulin resistance (IR) has a close relationship with the main clinical manifestations of patients with PCOS; hence, the research and development of new drugs to treat PCOS by improving IR is a desiderate task at present. Resveratrol…
View article: Pyrroloquinoline Quinone Inhibits PCSK9-NLRP3 Mediated Pyroptosis of Leydig Cells in Obese Mice
Pyrroloquinoline Quinone Inhibits PCSK9-NLRP3 Mediated Pyroptosis of Leydig Cells in Obese Mice Open
View article: Correction: Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome
Correction: Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome Open
View article: Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway
Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway Open
Spermatogenic dysfunction is one of the major secondary complications of diabetes; however, the underlying mechanisms remain ill-defined, and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfun…
View article: Effects of Sleep Disorders and Circadian Rhythm Changes on Male Reproductive Health: A Systematic Review and Meta-analysis
Effects of Sleep Disorders and Circadian Rhythm Changes on Male Reproductive Health: A Systematic Review and Meta-analysis Open
Objectives: The purpose of this study was to elucidate the relationship between sleep disorders and male reproductive health, and to explore the underlying mechanisms via a systematic review and meta-analysis. Methods: PubMed, Embase, The …
View article: The Impact of Mobile-Assisted Language Learning on English as a Foreign Language Learners’ Vocabulary Learning Attitudes and Self-Regulatory Capacity
The Impact of Mobile-Assisted Language Learning on English as a Foreign Language Learners’ Vocabulary Learning Attitudes and Self-Regulatory Capacity Open
Over the past decades, English as a foreign language (EFL) learning has witnessed a heightened interest in the role of mobile-assisted language learning (MALL) in vocabulary learning. To shed more light on the impact of MALL on vocabulary …
View article: Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome
Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome Open