2025-06-05
Subacute ruminal acidosis induces hepatic injury in dairy goats via oxidative stress and ferritinophagy-ferroptosis axis
2025-06-05 • Ning Su, Yanan Zhao, Can Zhang, Yuhong He, Chong Peng, Bo Liu, Caijun Zhao, Xiaoyu Hu, Yunhe Fu, Yang Liu, Yunfeng Qiu
Increasing the proportion of high-concentrate feed in ruminant diets can rapidly enhance milk production and overall performance. Prolonged feeding of high-concentrate (HC) diet may reduce ruminal pH, potentially inducing subacute rumen acidosis (SARA). Large amounts of lipopolysaccharide (LPS) are produced and enter the bloodstream through the damaged rumen barrier, accumulating in the liver tissue, causing inflammation. Studies indicate LPS can induce liver injury in mice through ferroptosis activation. However,…