Cancan Zhou
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View article: Endoscopic ultrasound elastography in solid pancreatic lesions: individual and combined performance of strain ratio, fat-lesion strain ratio, and mean strain histogram for diagnosing pancreatic ductal adenocarcinoma
Endoscopic ultrasound elastography in solid pancreatic lesions: individual and combined performance of strain ratio, fat-lesion strain ratio, and mean strain histogram for diagnosing pancreatic ductal adenocarcinoma Open
This study aims to compare three different elastography parameters to evaluate their efficacy in diagnosing Pancreatic Ductal Adenocarcinoma (PDAC) and provide a semi-quantitative or quantitative assessment method for endoscopic ultrasound…
View article: A novel approach to facilitate guidewire placement in endoscopic ultrasound-guided biliary drainage
A novel approach to facilitate guidewire placement in endoscopic ultrasound-guided biliary drainage Open
View article: FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia–reperfusion injury
FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia–reperfusion injury Open
Our study reveals a crucial role of CoQ10 in ferroptosis and highlights the potential of CoQ10 as a promising target for intestinal IRI treatment.
View article: A new method of endoscopic ultrasound and cholangioscopy-guided gastroenterostomy
A new method of endoscopic ultrasound and cholangioscopy-guided gastroenterostomy Open
View article: Improved gut microbiota by selenium-enriched Bifidobacterium longum DD98 alleviates chemotherapy-induced intestinal mucositis via inhibiting the STING pathway
Improved gut microbiota by selenium-enriched Bifidobacterium longum DD98 alleviates chemotherapy-induced intestinal mucositis via inhibiting the STING pathway Open
View article: Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-catenin
Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-catenin Open
NNK potentially induces PC progression through the LINC00857/β-catenin axis. These findings provide new perspectives on the mechanisms of PC progression and highlight the clinical relevance of smoking cessation for preventing PC.
View article: Comparative diagnostic efficacy and safety of ultrasound-guided percutaneous transhepatic biopsy and endoscopic ultrasound-guided fine-needle aspiration biopsy for gallbladder tumors
Comparative diagnostic efficacy and safety of ultrasound-guided percutaneous transhepatic biopsy and endoscopic ultrasound-guided fine-needle aspiration biopsy for gallbladder tumors Open
The objective of this study was to compare the diagnostic efficacy and safety of ultrasound-guided percutaneous transhepatic gallbladder biopsy (PTGB) with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the assessment of …
View article: Causal role of 731 immune cells in pancreatic cancer: a Mendelian Randomization study
Causal role of 731 immune cells in pancreatic cancer: a Mendelian Randomization study Open
Background: Pancreatic cancer poses a significant worldwide health challenge. Immune cells are implicated in pancreatic cancer progression and therapy, yet the precise influence of distinct subsets of immune cells remains largely unexplore…
View article: Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9 Open
View article: The Effects of Perioperative Corticosteroids on Postoperative Complications After Pancreatoduodenectomy: A Debated Topic of Systematic Review and Meta-analysis
The Effects of Perioperative Corticosteroids on Postoperative Complications After Pancreatoduodenectomy: A Debated Topic of Systematic Review and Meta-analysis Open
Background The intraoperative administration of corticosteroids has been shown to improve postoperative outcomes in patients undergoing surgery; however, the impact of corticosteroids on complications following pancreatoduodenectomy (PD) r…
View article: Knowledge, attitude and practice towards arthroscopic shoulder surgery in patients with rotator cuff tear: cross-sectional study
Knowledge, attitude and practice towards arthroscopic shoulder surgery in patients with rotator cuff tear: cross-sectional study Open
Objectives This cross-sectional study aimed to explore the knowledge, attitude and practice (KAP) of patients with rotator cuff tears towards arthroscopic shoulder surgery (ASS), based on the hypothesis that the knowledge of the procedure …
View article: STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice
STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice Open
Methotrexate (MTX), an anti-metabolite agent, is a widely used chemotherapeutic anticancer drug, but its hepatotoxicity severely limits its clinical application. Nevertheless, the precise mechanisms of MTX-caused liver damage are extremely…
View article: Huaier enhances the tumor-killing effect and reverses gemcitabine-induced stemness by suppressing FoxM1
Huaier enhances the tumor-killing effect and reverses gemcitabine-induced stemness by suppressing FoxM1 Open
Overall, this study illustrates that Huaier augments the tumor-killing effect of gemcitabine through suppressing the stemness induced by gemcitabine in a FoxM1-dependent way. These results indicate that Huaier can be applied to overcome ge…
View article: Research landscape of abdominal adhesions from 2004 to 2023: A bibliometric analysis
Research landscape of abdominal adhesions from 2004 to 2023: A bibliometric analysis Open
Adhesions are the most common complication of abdominal or pelvic surgery and remain a challenging problem. To better understand the development tendency of abdominal adhesions, we performed a comprehensive bibliometric analysis of the fie…
View article: Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery
Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery Open
Chemotherapy-related cognitive deficits (CRCI) as one of the common adverse drug reactions during chemotherapy that manifest as memory, attention, and executive function impairments. However, there are still no effective pharmacological th…
View article: Clinical features of omicron SARS-CoV-2 variants infection associated with co-infection and ICU-acquired infection in ICU patients
Clinical features of omicron SARS-CoV-2 variants infection associated with co-infection and ICU-acquired infection in ICU patients Open
Background Although the decreasing rate of hospital admission in the omicron wave has led countries to loosen control, still the patients requires ICU admission. It is common for viral respiratory infections to be co-infected with bacteria…
View article: Disputes and Challenges of Immune Checkpoint Inhibitors in Gastrointestinal Cancers
Disputes and Challenges of Immune Checkpoint Inhibitors in Gastrointestinal Cancers Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: Visual Observation of Abdominal Adhesion Progression Based on an Optimized Mouse Model of Postoperative Abdominal Adhesions
Visual Observation of Abdominal Adhesion Progression Based on an Optimized Mouse Model of Postoperative Abdominal Adhesions Open
Background: There is no clear description of the evolution of the progression of abdominal adhesions over time. Method: The optimized model was selected using different adhesion scoring systems. Then, this model was used to o…
View article: An amino acid metabolism-based seventeen-gene signature correlates with the clinical outcome and immune features in pancreatic cancer
An amino acid metabolism-based seventeen-gene signature correlates with the clinical outcome and immune features in pancreatic cancer Open
Background: Pancreatic cancer is an aggressive tumor with a low 5-year survival rate and primary resistance to most therapy. Amino acid (AA) metabolism is highly correlated with tumor growth, crucial to the aggressive biological behavior o…
View article: Long survival in a pancreatic carcinoma patient with multi-organ toxicities after sintilimab treatment: A case report
Long survival in a pancreatic carcinoma patient with multi-organ toxicities after sintilimab treatment: A case report Open
Pancreatic carcinoma is the leading cause of death among digestive malignancies in China. In particular, there is no breakthrough in prolonging the survival of pancreatic cancer patients with chemical and targeted therapies. Tumor immunoth…
View article: Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome
Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome Open
View article: Integrated analysis of necroptosis-related lncRNAs for prognosis and immunotherapy of patients with pancreatic adenocarcinoma
Integrated analysis of necroptosis-related lncRNAs for prognosis and immunotherapy of patients with pancreatic adenocarcinoma Open
Accumulating studies have revealed that necroptosis plays a vital role in the occurrence and development of pancreatic adenocarcinoma (PAAD). We aimed to construct a prognostic model for PAAD on the basis of necroptosis-related lncRNAs (NR…
View article: Mutant p53-driven lncRNA LINC00857 promotes pancreatic cancer metastasis through OTUB1- mediated FOXM1 deubiquitination
Mutant p53-driven lncRNA LINC00857 promotes pancreatic cancer metastasis through OTUB1- mediated FOXM1 deubiquitination Open
Background p53 mutations are considered to be the second most common type of mutation in PC, and significantly promote its metastasis. However, the underlying molecular mechanisms, especially the regulatory relationship with long noncoding…
View article: Population Pharmacokinetics of Tigecycline: A Systematic Review
Population Pharmacokinetics of Tigecycline: A Systematic Review Open
Although tigecycline is widely used in clinical practice, its efficiency and optimal dosage regimens remain controversial. The purpose of this article was to help guide tigecycline dosing in different patient subpopulations through compari…
View article: Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome Open
Abdominal aortic aneurysm (AAA) is defined as a dilated aorta in diameter at least 1.5 times of a normal aorta. Our previous studies found that activating α7 nicotinic acetylcholine receptor (α7nAChR) had a protective effect on vascular in…
View article: Piezo1 Act as a Potential Oncogene in Pancreatic Cancer Progression
Piezo1 Act as a Potential Oncogene in Pancreatic Cancer Progression Open
View article: Tanreqing Inhibits LPS-Induced Acute Lung Injury In Vivo and In Vitro Through Downregulating STING Signaling Pathway
Tanreqing Inhibits LPS-Induced Acute Lung Injury In Vivo and In Vitro Through Downregulating STING Signaling Pathway Open
Acute lung injury (ALI) is a common life-threatening lung disease, which is mostly associated with severe inflammatory responses and oxidative stress. Tanreqing injection (TRQ), a Chinese patent medicine, is clinically used for respiratory…
View article: A combination of hybrid polydopamine-human keratinocyte growth factor nanoparticles and sodium hyaluronate for the efficient prevention of postoperative abdominal adhesion formation
A combination of hybrid polydopamine-human keratinocyte growth factor nanoparticles and sodium hyaluronate for the efficient prevention of postoperative abdominal adhesion formation Open
Postoperative abdominal adhesion (PAA) is one of the more universal complications of abdominal surgery with a frequent incidence. Currently available keratinocyte growth factor (KGF)-based glues for the prevention of adhesions remain a gre…
View article: Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer
Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer Open
View article: The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer
The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer Open