Candace R. Lewis
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View article: Psilocybin reduces depressive-like behavior and improves cognition in healthy aging mice via epigenetic regulation of plasticity- and immune-related genes
Psilocybin reduces depressive-like behavior and improves cognition in healthy aging mice via epigenetic regulation of plasticity- and immune-related genes Open
For many, cognitive and affective health declines through typical aging. Although cognitive and affective symptoms are often studied in isolation, they share substantial overlap, and arise, in part, from common biological processes. Aging …
View article: Associations between relative abundances of Bifidobacterium species in the gut and DNA methylation of cortisol-related genes in a pediatric population
Associations between relative abundances of Bifidobacterium species in the gut and DNA methylation of cortisol-related genes in a pediatric population Open
Introduction Human epigenetics, specifically DNA methylation, and the gut microbiome are dynamic systems influenced by environmental factors, such as diet and earlylife exposures, with profound implications for health and disease. Metaboli…
View article: Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research Open
Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamin…
View article: Peripheral DNA Methylation of Cortisol- and Serotonin-Related Genes Predicts Hippocampal Volume in a Pediatric Population
Peripheral DNA Methylation of Cortisol- and Serotonin-Related Genes Predicts Hippocampal Volume in a Pediatric Population Open
These findings support the validity of peripheral DNA methylation profiles for indirectly assessing hippocampal volume and development and underscore the importance of genotype and age considerations in research. Therefore, peripheral epig…
View article: The peripheral epigenome predicts white matter volume contingent on developmental stage: An ECHO study
The peripheral epigenome predicts white matter volume contingent on developmental stage: An ECHO study Open
Epigenetic processes, including DNA methylation, are emerging as key areas of interest for their potential roles as biomarkers and contributors to the risk of neurodevelopmental, psychiatric, and other brain-based disorders. Despite this g…
View article: The Developing Myeloarchitecture of the Human Cortex: Relationships between Intra-Cortical Myelination and Developing Cognitive Function
The Developing Myeloarchitecture of the Human Cortex: Relationships between Intra-Cortical Myelination and Developing Cognitive Function Open
Three important themes in neuroscience are parcellation, structure-function specificity, and neural plasticity. These themes relate to: 1. The ability to delineate brain regions, for example on the basis of their cellular composition, myel…
View article: APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory
APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory Open
Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) and other dementias compared to neurotypical (NT) adults. The ε4-allel…
View article: Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences
Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences Open
View article: <scp><i>FTO</i></scp> variation and early frontostriatal brain development in children
<span><i>FTO</i></span> variation and early frontostriatal brain development in children Open
Objective Common obesity‐associated genetic variants at the fat mass and obesity‐associated ( FTO ) locus have been associated with appetitive behaviors and altered structure and function of frontostriatal brain regions. The authors aimed …
View article: Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices
Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices Open
Background Food parenting practices are associated with child weight. Such associations may reflect the effects of parents' practices on children's food intake and weight. However, longitudinal, qualitative, and behavioral genetic evidence…
View article: Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders
Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders Open
Purpose: Precision medicine is an emerging intervention paradigm that leverages knowledge of risk factors such as genotypes, lifestyle, and environment toward proactive and personalized interventions. Regarding genetic risk factors, exampl…
View article: Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices
Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices Open
Data used in the manuscript "Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices" by Jansen E., Naymik M., Thapaliya G., Huentelman M., Beauchemin J., D'Sa V., Lewis C.R.…
View article: Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices
Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices Open
Data used in the manuscript "Parent-reported child appetite moderates relationships between child genetic obesity risk and parental feeding practices" by Jansen E., Naymik M., Thapaliya G., Huentelman M., Beauchemin J., D'Sa V., Lewis C.R.…
View article: Editorial: What is up with psychedelics anyway?
Editorial: What is up with psychedelics anyway? Open
EDITORIAL article Front. Neurosci., 13 March 2023Sec. Neuropharmacology Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1161868
View article: At-home dried blood spot (DBS) collection to increase population heterogeneity representation in pediatric research: An ECHO study
At-home dried blood spot (DBS) collection to increase population heterogeneity representation in pediatric research: An ECHO study Open
Self-collection of dried blood samples (DBS) in the participant's home provides an alternative to university/hospital visits for research and has the potential to improve the representation of population heterogeneity in research. This stu…
View article: Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD
Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD Open
Background Previous research has demonstrated that epigenetic changes in specific hypothalamic-pituitary-adrenal (HPA) genes may predict successful psychotherapy in post-traumatic stress disorder (PTSD). A recent Phase 3 clinical trial rep…
View article: Leukocyte and cytokine variables in asymptomatic Pugs at genetic risk of necrotizing meningoencephalitis
Leukocyte and cytokine variables in asymptomatic Pugs at genetic risk of necrotizing meningoencephalitis Open
Background Necrotizing meningoencephalitis (NME, aka Pug dog encephalitis) is an inflammatory brain condition associated with advanced disease at initial presentation, rapid progression, and poor response to conventional immunomodulatory t…
View article: Family SES Is Associated with the Gut Microbiome in Infants and Children
Family SES Is Associated with the Gut Microbiome in Infants and Children Open
Background: While early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert in…
View article: Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance Open
To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). sv…
View article: Smoking is associated with impaired verbal learning and memory performance in women more than men
Smoking is associated with impaired verbal learning and memory performance in women more than men Open
Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by …
View article: Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood
Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood Open
View article: Epigenetic differences in inflammation genes of monozygotic twins are related to parent-child emotional availability and health
Epigenetic differences in inflammation genes of monozygotic twins are related to parent-child emotional availability and health Open
View article: Rostral Anterior Cingulate Thickness Predicts the Emotional Psilocybin Experience
Rostral Anterior Cingulate Thickness Predicts the Emotional Psilocybin Experience Open
Psilocybin is the psychoactive compound of mushrooms in the psilocybe species. Psilocybin directly affects a number of serotonin receptors, with highest affinity for the serotonin 2A receptor (5HT-2Ar). Generally, the effects of psilocybin…
View article: Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors
Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors Open
In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer’s disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we develope…
View article: Author response: Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors
Author response: Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In humans, a first-degree family history o…
View article: Dopaminergic gene methylation is associated with cognitive performance in a childhood monozygotic twin study
Dopaminergic gene methylation is associated with cognitive performance in a childhood monozygotic twin study Open
Individual differences in cognitive function are due to a combination of heritable and non-heritable factors. A large body of evidence from clinical, cognitive, and pharmacological neuroscience implicates dopaminergic gene variants as modu…
View article: Dopaminergic gene methylation is associated with cognitive performance in a childhood monozygotic twin study
Dopaminergic gene methylation is associated with cognitive performance in a childhood monozygotic twin study Open
Individual differences in cognitive function are due to a combination of heritable and non-heritable factors. A large body of evidence from clinical, cognitive, and pharmacological neuroscience implicates dopaminergic gene variants as modu…
View article: Dopaminergic Gene Methylation is Associated with Cognitive Performance in a Childhood Monozygotic Twin Study
Dopaminergic Gene Methylation is Associated with Cognitive Performance in a Childhood Monozygotic Twin Study Open
Individual differences in cognitive function are due to a combination of heritable and non-heritable factors. A large body of evidence from clinical, cognitive, and pharmacological neuroscience implicates dopaminergic gene variants as modu…
View article: The effect of litter separation on methamphetamine-conditioned place preference in post-partum dams
The effect of litter separation on methamphetamine-conditioned place preference in post-partum dams Open
Methamphetamine (METH) abuse among women has recently increased to levels comparable to those observed in men. Although studies using animal models of addiction have begun to include more female subjects, examination of the effects of drug…
View article: Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats
Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats Open