Candice D. Fike
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View article: Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia
Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia Open
View article: Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia
Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia Open
Objective. Information is needed to guide the design of randomized controlled trials (RCTs) evaluating L-citrulline as a therapy for premature infants with pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH). Our goa…
View article: Impact of <scp>l</scp>‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells
Impact of <span>l</span>‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells Open
Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l ‐arginine precursor, l ‐citrulline, improves NO signaling and has therapeutic potential in PH. However, there is evidence that l ‐cit…
View article: Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future
Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future Open
Approximately 8–42% of premature infants with chronic lung disease of prematurity, bronchopulmonary dysplasia (BPD), develop pulmonary hypertension (PH). Infants with BPD-PH carry alarmingly high mortality rates of up to 47%. Effective PH-…
View article: Pharmacokinetics of l-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
Pharmacokinetics of l-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension Open
View article: Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs
Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs Open
Concomitant with developing pulmonary hypertension (PH), newborn piglets exposed to chronic hypoxia develop pulmonary vascular NO signaling impairments. PH is reduced and NO signaling is improved in chronically hypoxic piglets treated with…
View article: Correction: The american pediatric society and society for pediatric research joint statement against racism and social injustice
Correction: The american pediatric society and society for pediatric research joint statement against racism and social injustice Open
View article: L‐citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells
L‐citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells Open
The L‐arginine precursor, L‐citrulline, re‐couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs. L‐arginine can induce arginase, which,…
View article: Racism and social injustice as determinants of child health: the American Pediatric Society Issue of the Year
Racism and social injustice as determinants of child health: the American Pediatric Society Issue of the Year Open
View article: The american pediatric society and society for pediatric research joint statement against racism and social injustice
The american pediatric society and society for pediatric research joint statement against racism and social injustice Open
View article: <scp>l</scp>‐Citrulline treatment alters the structure of the pulmonary circulation in hypoxic newborn pigs
<span>l</span>‐Citrulline treatment alters the structure of the pulmonary circulation in hypoxic newborn pigs Open
Background Dysregulated nitric oxide (NO) signaling contributes to chronic hypoxia (CH)‐induced pulmonary hypertension (PH). NO signaling is improved and pulmonary vascular resistance (PVR) is reduced in CH piglets treated with the l ‐argi…
View article: Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review
Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review Open
View article: Combined <scp>l</scp>-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
Combined <span>l</span>-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs Open
Newborn pigs with chronic hypoxia-induced pulmonary hypertension (PH) have evidence of endothelial nitric oxide synthase (eNOS) uncoupling. In this model, we showed that therapies that promote eNOS coupling, either tetrahydrobiopterin (BH …
View article: Respiratory Medications in Infants <29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium
Respiratory Medications in Infants <29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium Open
View article: Reactive oxygen species modulate Na<sup>+</sup>-coupled neutral amino acid transporter 1 expression in piglet pulmonary arterial endothelial cells
Reactive oxygen species modulate Na<sup>+</sup>-coupled neutral amino acid transporter 1 expression in piglet pulmonary arterial endothelial cells Open
We have previously shown that Na + -coupled neutral amino acid transporter 1 (SNAT1) modulates nitric oxide (NO) production in pulmonary arterial endothelial cells (PAECs) from newborn piglets. Specifically, the ability to increase NO prod…
View article: Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia
Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia Open
View article: A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a deadly disease with no cure. Alternate conversion of angiotensin II (AngII) to angiotensin-(1–7) (Ang-(1–7)) by angiotensin-converting enzyme 2 (ACE2) resulting in Mas receptor (Mas1) activation i…
View article: Pulmonary hypertension in the premature infant population: Analysis of echocardiographic findings and biomarkers
Pulmonary hypertension in the premature infant population: Analysis of echocardiographic findings and biomarkers Open
Objective Extremely low gestational age neonates (ELGANs) are at risk for pulmonary hypertension (PH). We hypothesized that PH, defined by echocardiogram at 36 weeks gestational age (GA), would associate with respiratory morbidity, increas…
View article: Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study
Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study Open
View article: Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia
Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia Open
View article: Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs Open
We previously showed that newborn piglets who develop pulmonary hypertension during exposure to chronic hypoxia have diminished pulmonary vascular nitric oxide (NO) production and evidence of endothelial NO synthase (eNOS) uncoupling (Fike…