Candice E. Paulsen
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View article: Two calmodulin binding elements contribute distinctly to TRPA1 calcium desensitization
Two calmodulin binding elements contribute distinctly to TRPA1 calcium desensitization Open
The 'wasabi receptor', TRPA1, is a critical pain receptor that is activated by reactive environmental and endogenous irritants to initiate pain perception, local inflammation, and protective behaviors. TRPA1 is a calcium-permeable ion chan…
View article: Calmodulin binding is required for calcium mediated TRPA1 desensitization
Calmodulin binding is required for calcium mediated TRPA1 desensitization Open
TRPA1 is an essential calcium (Ca2+)-permeable channel involved in nociception and inflammation. It exhibits complex and mechanistically elusive Ca2+ regulation with initial potentiation then rapid desensitization. We find that the univers…
View article: Calmodulin binding is required for calcium mediated TRPA1 desensitization
Calmodulin binding is required for calcium mediated TRPA1 desensitization Open
Calcium (Ca 2+ ) ions affect nearly all aspects of biology. Excessive Ca 2+ entry is cytotoxic and Ca 2+ - mobilizing receptors have evolved diverse mechanisms for tight regulation that often include Calmodulin (CaM). TRPA1, an essential C…
View article: Molecular mechanism of hyperactivation conferred by a truncation of TRPA1
Molecular mechanism of hyperactivation conferred by a truncation of TRPA1 Open
A drastic TRPA1 mutant (R919*) identified in CRAMPT syndrome patients has not been mechanistically characterized. Here, we show that the R919* mutant confers hyperactivity when co-expressed with wild type (WT) TRPA1. Using functional and b…
View article: Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Reveals New Gating Insights
Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Reveals New Gating Insights Open
This file contains all graphed data included in main manuscript figures and a table of all cloning details for constructs used in these experiments.
View article: Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1
Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1 Open
RAD51 is a critical recombinase that functions in concert with auxiliary mediator proteins to direct the homologous recombination (HR) DNA repair pathway. We show that Cys319 RAD51 possesses nucleophilic characteristics and is important fo…
View article: Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights
Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights Open
The wasabi receptor, TRPA1, is a non-selective homotetrameric cation channel expressed in primary sensory neurons of the pain pathway, where it is activated by diverse chemical irritants. A direct role for TRPA1 in human health has been hi…
View article: Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1
Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1 Open
The TRPA1 ion channel is a chemosensory receptor that is critical for detecting noxious chemical agents that elicit or exacerbate pain or itch. Here we use structural and electrophysiological methods to elucidate how a broad class of react…