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View article: p:Hishing for T cells: Using ‘chimeric antigen-presenting’ (CAP) T cells to target and eliminate antigen-specific T cell populations 4027
p:Hishing for T cells: Using ‘chimeric antigen-presenting’ (CAP) T cells to target and eliminate antigen-specific T cell populations 4027 Open
Description Many autoimmune conditions are caused, in part, by T cell populations that target and damage ‘self’ tissue. It is therefore of therapeutic interest to eliminate such populations while leaving the healthy T cell repertoire intac…
View article: Identifying recommendations to improve therapy-led management of complex regional pain syndrome in England
Identifying recommendations to improve therapy-led management of complex regional pain syndrome in England Open
Background Complex Regional Pain Syndrome (CRPS) is a distressing pain condition that can lead to significant burdens for individuals and society. A small number of specialist CRPS-practice services exist, but access is limited; most patie…
View article: Development of clinical recommendations to improve the care of people living with chronic pain as a long term or late effect of cancer and its treatment
Development of clinical recommendations to improve the care of people living with chronic pain as a long term or late effect of cancer and its treatment Open
Background Chronic pain is a common side effect of cancer treatment and is frequently cited as a top concern and unmet need for cancer survivors. This paper outlines the development of clinical recommendations to better support people with…
View article: Optimising clinical trial methods for complex regional pain syndrome: a methodological framework (OptiMeth-CRPS)
Optimising clinical trial methods for complex regional pain syndrome: a methodological framework (OptiMeth-CRPS) Open
Introduction: Complex regional pain syndrome (CRPS) is a rare, disabling pain disorder. Systematic reviews have identified a critical lack of high-quality clinical trial evidence to inform the management of CRPS. There is an urgent need to…
View article: Feasibility study of a home-based sensory training system (STS) device for type 1 complex regional pain syndrome in England: Lessons learnt
Feasibility study of a home-based sensory training system (STS) device for type 1 complex regional pain syndrome in England: Lessons learnt Open
Introduction Sensory discrimination training has demonstrated improvements in two-point discrimination and pain reduction in people with chronic pain. We tested the feasibility and acceptability of a novel Sensory Training System (STS) dev…
View article: OptiMeth-CRPS: A Methodological Framework for Optimising Clinical Trial Methods for Complex Regional Pain Syndrome (CRPS)
OptiMeth-CRPS: A Methodological Framework for Optimising Clinical Trial Methods for Complex Regional Pain Syndrome (CRPS) Open
Complex regional pain syndrome (CRPS) is a rare and disabling pain disorder. Systematic reviews have identified a critical lack of adequately powered, high quality clinical trial evidence to inform the management of CRPS. There is an urgen…
View article: Establishing a Public Involvement Network for Chronic Pain Research in the United Kingdom: Lessons Learned
Establishing a Public Involvement Network for Chronic Pain Research in the United Kingdom: Lessons Learned Open
Introduction The Consortium to Research Individual, Interpersonal and Social Influences in Pain (CRIISP) is a 4‐year UK university collaboration investigating how thoughts and feelings, personal relationships and lifestyle can affect chron…
View article: Population genomics and molecular epidemiology of wheat powdery mildew in Europe
Population genomics and molecular epidemiology of wheat powdery mildew in Europe Open
Agricultural diseases are a major threat to sustainable food production. Yet, for many pathogens we know exceptionally little about their epidemiological and population dynamics, and this knowledge gap is slowing the development of efficie…
View article: OptiMeth-CRPS: A Methodological Framework for Optimising Clinical Trial Methods for Complex Regional Pain Syndrome (CRPS)
OptiMeth-CRPS: A Methodological Framework for Optimising Clinical Trial Methods for Complex Regional Pain Syndrome (CRPS) Open
Complex regional pain syndrome (CRPS) is a rare and disabling pain disorder. Systematic reviews have identified a critical lack of adequately powered, high quality clinical trial evidence to inform the management of CRPS. There is an urgen…
View article: OptiMeth-CRPS: A Methodological Framework for Optimising Clinical Trial Methods for Complex Regional Pain Syndrome (CRPS)
OptiMeth-CRPS: A Methodological Framework for Optimising Clinical Trial Methods for Complex Regional Pain Syndrome (CRPS) Open
Complex regional pain syndrome (CRPS) is a rare and disabling pain disorder. Systematic reviews have identified a critical lack of adequately powered, high quality clinical trial evidence to inform the management of CRPS. There is an urgen…
View article: A malevolent force: A qualitative exploration of perceptions of changes in bodily function and sensations in complex regional pain syndrome
A malevolent force: A qualitative exploration of perceptions of changes in bodily function and sensations in complex regional pain syndrome Open
Research has established that people with complex regional pain syndrome (CRPS) experience profound changes in bodily function and sensations. However, the subjective perceptions of these changes to bodily function and sensations have not …
View article: Population genomics and molecular epidemiology of wheat powdery mildew in Europe
Population genomics and molecular epidemiology of wheat powdery mildew in Europe Open
Agricultural diseases are a major threat to sustainable food production. Yet, for many pathogens we know exceptionally little about their epidemiological and population dynamics, and this knowledge gap is slowing the development of efficie…
View article: Nurse‐led care for people with early rheumatoid arthritis: Interview study with thematic analysis
Nurse‐led care for people with early rheumatoid arthritis: Interview study with thematic analysis Open
Aims To develop an understanding of what comprises nurse‐led care in early rheumatoid arthritis from the perspective of rheumatology nurse specialists in England. Design Qualitative study. Methods Semi‐structured telephone interviews with …
View article: P-229 Evaluating the implementation of the Dorothy house service redesign
P-229 Evaluating the implementation of the Dorothy house service redesign Open
Background In 2022, Dorothy House Hospice Care embarked on implementing a comprehensive redesign of services in line with its mission to ensure everyone has access to outstanding palliative and end of life care. The services redesign had f…
View article: Is there a role for citizen science in death and dying research?
Is there a role for citizen science in death and dying research? Open
The COVID-19 pandemic has brought conversations about death and dying to the fore in a way not experienced for generations. This raises questions around perceptions of death and dying; the role of healthcare and the community in care; and …
View article: ‘I think it affects every aspect of my life, really’: Cancer survivors’ experience of living with chronic pain after curative cancer treatment in England, UK
‘I think it affects every aspect of my life, really’: Cancer survivors’ experience of living with chronic pain after curative cancer treatment in England, UK Open
Aim To explore cancer survivors’ experiences of living with chronic pain after curative cancer treatment in England, UK. Methods A qualitative study using telephone interviews with adult cancer survivors experiencing chronic pain after cur…
View article: An international study to explore the feasibility of collecting standardised outcome data for Complex Regional Pain Syndrome: recommendations for an international clinical research registry
An international study to explore the feasibility of collecting standardised outcome data for Complex Regional Pain Syndrome: recommendations for an international clinical research registry Open
Introduction Complex Regional Pain Syndrome (CRPS) is a persistent pain condition with low prevalence. Multi-centre collaborative research is needed to attain sufficient sample sizes for meaningful studies. This international observational…
View article: Better post-operative prediction and management of chronic pain in adults after total knee replacement: the multidisciplinary STAR research programme including RCT
Better post-operative prediction and management of chronic pain in adults after total knee replacement: the multidisciplinary STAR research programme including RCT Open
Background The treatment of osteoarthritis with knee replacement aims to reduce pain and disability. However, some people experience chronic pain. Objectives To improve outcomes for people with chronic pain after knee replacement by identi…
View article: Resilience in patients with complex regional pain syndrome 1—a cross-sectional analysis of patients participating in a cross-sectional cohort study
Resilience in patients with complex regional pain syndrome 1—a cross-sectional analysis of patients participating in a cross-sectional cohort study Open
Objective To assess the degree of resilience in patients with complex regional pain syndrome (CRPS) 1, to explore the relationship between resilience and patient-related outcome measurements and to describe a pattern of clinical manifestat…
View article: Sensory training system for use at home by people with complex regional pain syndrome in England: protocol for a proof-of-concept study
Sensory training system for use at home by people with complex regional pain syndrome in England: protocol for a proof-of-concept study Open
Introduction Complex regional pain syndrome (CRPS) is a disabling and distressing chronic pain condition characterised by a range of sensory, motor, autonomic and trophic symptoms. UK guidelines recommend therapy interventions to help norm…
View article: Optimising management of complex regional pain syndrome to improve clinical outcomes throughout the therapy care pathway in England: Protocol for a qualitative interview and observational study with patients and clinicians
Optimising management of complex regional pain syndrome to improve clinical outcomes throughout the therapy care pathway in England: Protocol for a qualitative interview and observational study with patients and clinicians Open
Introduction Complex Regional Pain Syndrome (CRPS) is a disabling and distressing chronic pain condition characterised by a range of sensory, motor, autonomic and trophic symptoms. Guidelines recommend early referral for therapies that pro…
View article: Hospital practitioner views on the benefits of continence education and best ways to provide training
Hospital practitioner views on the benefits of continence education and best ways to provide training Open
Aim The aim of the study was to explore practitioners' experiences and perspectives on continence training, in order to understand its relevance to practice and how take‐up of, and engagement with, such training may be improved. Design 27 …
View article: Systematic co-development and testing of a digital behaviour change intervention for osteoarthritis and physical activity: Theoretical mapping and acceptability study
Systematic co-development and testing of a digital behaviour change intervention for osteoarthritis and physical activity: Theoretical mapping and acceptability study Open
Objective Osteoarthritis (OA) affects 8.75 million people in the UK. Physical activity (PA) is recommended as a core treatment, yet nearly half of people with OA are inactive. Accessible and user-friendly interventions are needed to motiva…
View article: P-208 Development of a comprehensive education programme ‘the tulip standard essentials of care’, securing the future of our workforce
P-208 Development of a comprehensive education programme ‘the tulip standard essentials of care’, securing the future of our workforce Open
Background Our hospice vision is to meet the needs of more people. Our unregistered staff are key in helping us to provide more care and we are expanding this workforce. It is essential that these staff are equipped to meet the changing de…
View article: P-183 Understanding local communities’ needs for palliative and end of life care and bereavement support
P-183 Understanding local communities’ needs for palliative and end of life care and bereavement support Open
Background Dorothy House Hospice aims to provide outstanding palliative and end-of-life care, and bereavement support. With demand for these services rising, it is important to understand the changing needs of the local community to ensure…
View article: P-101 Exploring patients’ and families’ experiences of service adaptations in the context of COVID-19
P-101 Exploring patients’ and families’ experiences of service adaptations in the context of COVID-19 Open
Background Necessary service changes arising from the COVID-19 pandemic provided an opportunity to review patients' preferences for the delivery of hospice care and support. Many face-to-face services were replaced with telephone and virtu…
View article: P-135 Living well with lung disease: the impact of a hospice-led multidisciplinary respiratory clinic
P-135 Living well with lung disease: the impact of a hospice-led multidisciplinary respiratory clinic Open
Background Lung diseases account for more than 700,000 hospital admissions, and leads to 115,000 deaths in the UK each year (British Lung Foundation. Lung disease in the UK. [Internet]. [cited 31 May 2022]; Public Health England. Respirato…