Canfeng Zhang
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View article: Pathogenic mechanism and therapeutic intervention of impaired N <sup>7</sup> -methylguanosine (m <sup>7</sup> G) tRNA modification
Pathogenic mechanism and therapeutic intervention of impaired N <sup>7</sup> -methylguanosine (m <sup>7</sup> G) tRNA modification Open
Mutations modification enzymes including the tRNA N 7 -methylguanosine (m 7 G) methyltransferase complex component WDR4 were frequently found in patients with neural disorders, while the pathogenic mechanism and therapeutic intervention st…
View article: RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma Open
View article: YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner
YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner Open
Accumulation of DNA damage in the lung induces cellular senescence and promotes age-related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding the mechanistic regulation of DNA damage repair is important for anti-ag…
View article: UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1
UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1 Open
Premature telomere shortening is a known factor correlated to idiopathic pulmonary fibrosis (IPF) occurrence, which is a chronic, progressive, age-related disease with high mortality. The etiology of IPF is still unknown. Here, we found th…
View article: BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance
BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance Open
View article: Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines
Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines Open
View article: METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability
METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability Open
Telomeric repeat-containing RNA (TERRA) is a type of long non-coding RNA transcribed from telomeres, and it forms R-loops by invasion into telomeric DNA. Since either an excessive or inadequate number of R-loops leads to telomere instabili…
View article: Metanephric Adenofibroma in a young adult
Metanephric Adenofibroma in a young adult Open
cAsEA 29-year-old female patient was admitted after a computed tomography (CT) scan showing a neoplasm measuring 4.5×4.0×4.5cmlocated in the middle and dorsal part of the left kidney (Figure -1).In the CT plain scan phase, the neoplasm had…