Canjun Zeng
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View article: Recent Advances in the Clinical Treatment of Osteochondral Lesions of the Talus (2021–2023): A Narrative Review
Recent Advances in the Clinical Treatment of Osteochondral Lesions of the Talus (2021–2023): A Narrative Review Open
The management of osteochondral lesions of the talus (OLT) remains a challenging clinical issue. With advances in theory and technology, treatment options for OLT have expanded significantly. This review examines recent progress in the cli…
View article: Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis
Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis Open
Background Diabetic polyneuropathy (DPN) is a common diabetes complication with limited treatment options. We aimed to identify circulating plasma proteins as potential therapeutic targets for DPN using Mendelian Randomization (MR). Method…
View article: Effects of Pathological Characteristics on Functional Scores and Surgical Satisfaction in Patients after Hallux Valgus Surgery
Effects of Pathological Characteristics on Functional Scores and Surgical Satisfaction in Patients after Hallux Valgus Surgery Open
Objective Few studies have explored the relationship between the pathological characteristics of hallux valgus and surgical outcomes. The aim of our study was to report the influence of pathological characteristics such as the tibial sesam…
View article: Autologous osteoperiosteal transplantation for cystic osteochondral lesions of the talus: Bone reconstruction is essential
Autologous osteoperiosteal transplantation for cystic osteochondral lesions of the talus: Bone reconstruction is essential Open
AOPT is an effective and acceptable technique for cystic OLT. Bone reconstruction is essential for large cystic OLT. How to get better bony articular reconstruction and avoid cyst recurrence should still be paid more attention.
View article: Exploration of the <scp>miR</scp> ‐187‐3p/ <scp>CNR2</scp> pathway in modulating osteoblast differentiation and treating postmenopausal osteoporosis through mechanical stress
Exploration of the <span>miR</span> ‐187‐3p/ <span>CNR2</span> pathway in modulating osteoblast differentiation and treating postmenopausal osteoporosis through mechanical stress Open
This study aimed to explore how mechanical stress affects osteogenic differentiation via the miR‐187‐3p/CNR2 pathway. To conduct this study, 24 female C57BL/6 mice, aged 8 weeks, were used and divided into four groups. The Sham and OVX gro…
View article: Emu oil enhances cutaneous wound healing by modulating inflammation through promoting macrophage M2 polarization via MAPK signaling pathway
Emu oil enhances cutaneous wound healing by modulating inflammation through promoting macrophage M2 polarization via MAPK signaling pathway Open
Persistent inflammation impedes wound healing due to the excessive infiltration of inflammatory cells and the accumulation of pro-inflammatory cytokines. Emu oil (EO) exhibits strong anti-inflammatory properties, but the molecular mechanis…
View article: Aligned cryogel fibers incorporated 3D printed scaffold effectively facilitates bone regeneration by enhancing cell recruitment and function
Aligned cryogel fibers incorporated 3D printed scaffold effectively facilitates bone regeneration by enhancing cell recruitment and function Open
Reconstructing extensive cranial defects represents a persistent clinical challenge. Here, we reported a hybrid three-dimensional (3D) printed scaffold with modification of QK peptide and KP peptide for effectively promoting endogenous cra…
View article: Autologous Costal Chondral/Osteochondral Transplantation and Costa‐Derived Chondrocyte Implantation for Articular Cartilage Repair: Basic Science and Clinical Applications
Autologous Costal Chondral/Osteochondral Transplantation and Costa‐Derived Chondrocyte Implantation for Articular Cartilage Repair: Basic Science and Clinical Applications Open
There has been increasing application of autologous costal chondral/osteochondral transplantation (ACCT/ACOT) and costa‐derived chondrocyte implantation (ACCI) for articular cartilage repair over the past three decades. This review present…
View article: Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3 Open
Cartilage aging is a quintessential feature of knee osteoarthritis, and extracellular matrix (ECM) stiffening is a typical feature of cartilage aging. However, the mechanism of ECM stiffening to influence chondrocytes and downstream molecu…
View article: Autologous Costal Osteochondral Transplantation for Cystic Osteochondral Lesions of the Talus: Feasible and Effective
Autologous Costal Osteochondral Transplantation for Cystic Osteochondral Lesions of the Talus: Feasible and Effective Open
Objective Osteochondral lesions of the talus (OLT) is a common and clinically challenging disease. The optimal management is still under debate. The purpose of this prospective study was to investigate the feasibility and clinical outcomes…
View article: The Reliability and Accuracy of the Medial Malleolar Fracture Classification Based on <scp>3D CT</scp> Reconstruction
The Reliability and Accuracy of the Medial Malleolar Fracture Classification Based on <span>3D CT</span> Reconstruction Open
Objective There is a new medial malleolar fracture classification based on 3D CT reconstruction. However, there is no study assessing the reliability and accuracy of the new classification system and comparison between the new and the clas…
View article: Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion
Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion Open
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone. To determine how LRRK1 regulates osteoclast activity, we exam…
View article: Recent Progress in the Classification and Operation of Sacral Fractures
Recent Progress in the Classification and Operation of Sacral Fractures Open
Most sacral fractures are caused by high-energy, violent injuries, often accompanied by lumbosacral plexus injuries, which can cause instability of the posterior pelvic ring or lumbosacral junction in severe cases. Currently, the most comm…
View article: Autologous Osteoperiosteal Transplantation for the Treatment of Large Cystic Talar Osteochondral Lesions
Autologous Osteoperiosteal Transplantation for the Treatment of Large Cystic Talar Osteochondral Lesions Open
Objective The effectiveness of autologous osteoperiosteal transplantation (AOPT) for the treatment of large cystic talar osteochondral lesions (OCLs) should be further evaluated, and the postoperative cartilage coverage is questionable. Th…
View article: Circ0038632 modulates MiR-186/DNMT3A axis to promote proliferation and metastasis in osteosarcoma
Circ0038632 modulates MiR-186/DNMT3A axis to promote proliferation and metastasis in osteosarcoma Open
Osteosarcoma is a highly malignant solid tumor with poor prognosis, early metastasis, and rapid progression and has a high mortality rate, in which better therapeutic strategies are needed. Circ0038632, also known as circPLK1, is a tumor p…
View article: Activin B-activated Cdc42 signaling plays a key role in regulating adipose-derived mesenchymal stem cells-mediated skin wound healing
Activin B-activated Cdc42 signaling plays a key role in regulating adipose-derived mesenchymal stem cells-mediated skin wound healing Open
Background In our previous study, activin B in combination with ADSCs enhances skin wound healing. However, the underlying molecular mechanisms are not well studied. Cdc42 is recognized to play a critical role in the regulation of stem cel…
View article: The Biomechanical Evaluation of Plate Matching and Ideal Screw Trajectories on Internal Fixation of Tibial Plateau Fractures: A Finite Element Analysis
The Biomechanical Evaluation of Plate Matching and Ideal Screw Trajectories on Internal Fixation of Tibial Plateau Fractures: A Finite Element Analysis Open
This study was aimed to compare the biomechanical characteristics between the personalized plate system and the existing plate system in the internal fixation of tibial plateau fractures, and to explore the biomechanical advantages of the …
View article: Retrospective Analysis of Infection Factors in Secondary Internal Fixation after External Fixation for Open Fracture of a Long Bone: A Cohort of 117 Patients in a Two‐Center Clinical Study
Retrospective Analysis of Infection Factors in Secondary Internal Fixation after External Fixation for Open Fracture of a Long Bone: A Cohort of 117 Patients in a Two‐Center Clinical Study Open
Purpose . To investigate infection risk factors after secondary internal fixation (IF) of open fracture of a long bone with removed fixation frame and explore the safe range of feasible operation for abnormal inflammatory indicators. Metho…
View article: Identification and validation of MicroRNA-mRNA Networks in Dorsal Root Ganglia after Peripheral Nerve Injury
Identification and validation of MicroRNA-mRNA Networks in Dorsal Root Ganglia after Peripheral Nerve Injury Open
Changes in DRG after nerve injury involve neuronal damage, apoptosis, pain transmission, and activation of regenerative programs. It is unclear which genes and microRNAs may play a major role in this process. Therefore, this study performe…
View article: Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway
Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway Open
Mechanical stress promotes human ligamentum flavum cells (LFCs) to synthesize multitype collagens, leading to ligamentum flavum hypertrophy (LFH). However, the mechanism of mechanical stress in the formation of collagen remains unclear. Th…
View article: Endogenous Aβ induces osteoporosis through an mTOR-dependent inhibition of autophagy in bone marrow mesenchymal stem cells (BMSCs)
Endogenous Aβ induces osteoporosis through an mTOR-dependent inhibition of autophagy in bone marrow mesenchymal stem cells (BMSCs) Open
Our results suggested that endogenous Aβ might have induced osteoporosis through an mTOR-dependent inhibition of autophagy in BMSCs, which may explain the OP changes observed in AD patients.
View article: Reconstruction of Large Area of Deep Wound in the Foot and Ankle with Chimeric Anterolateral Thigh Perforator Flap
Reconstruction of Large Area of Deep Wound in the Foot and Ankle with Chimeric Anterolateral Thigh Perforator Flap Open
Objective To evaluate the clinical application and surgical efficacy of the chimeric perforator flap pedicled with the descending branch of the lateral circumflex femoral artery and the lateral thigh muscle flap for the reconstruction of t…
View article: Next‑generation sequencing of miRNAs and lncRNAs from rat femur and tibia under mechanical stress
Next‑generation sequencing of miRNAs and lncRNAs from rat femur and tibia under mechanical stress Open
Exercise intervention has become one of the most effective methods to prevent and treat osteoporosis, which is a common age‑related disease and seriously affects the health and quality of life of the elderly. However, the molecular mechani…
View article: Free flap transplantation combined with Ilizarov bone transport for the treatment of severe composite tibial and soft tissue defects
Free flap transplantation combined with Ilizarov bone transport for the treatment of severe composite tibial and soft tissue defects Open
Objective To evaluate the clinical efficacy of free flap transplantation combined with Ilizarov bone transport in the treatment of severe composite tibial and soft tissue defects. Methods We retrospectively analyzed the clinical data of 40…
View article: Emergency amputation necessitated within 24 hours by a human bite: a case report
Emergency amputation necessitated within 24 hours by a human bite: a case report Open
We herein review and analyze the diagnosis, treatment, and outcome of a severe infection caused by a human bite. A 68-year-old man was bitten on the forearm by a 3-year-old child. Rapid progression of infection, severe local and systemic p…
View article: Reconstruction of coronoid process of the ulna: a literature review
Reconstruction of coronoid process of the ulna: a literature review Open
As a pivotal part of the elbow joint structure, the coronoid process of the ulna plays a vital role in maintaining elbow joint stability. Loss of coronoid process height causes instability of the elbow joint depending on the fracture chara…
View article: Validation of a Chinese translation of the identification of functional ankle instability questionnaire
Validation of a Chinese translation of the identification of functional ankle instability questionnaire Open
To the Editor: Ankle sprains account for about 40% of all sports injuries, and 20% to 33% of ankle sprains will cause ankle instability.[1] Functional ankle instability (FAI) does not yet have an accurate and widely accepted measurable def…