Explanipedia

β-Hydroxybutyrate ameliorates lipopolysaccharide-induced liver injury through β-hydroxybutyrylation of the SOD2 protein in mice Open

Yan Zhang, Zhi-yuan Chen, Chen Zhang, Yue Sun, Zhichao Li , et al. · 2025

Septic liver injury is a major complication of sepsis, driven in part by oxidative stress-induced macrophage inflammasome activation and hepatocyte apoptosis. β-Hydroxybutyrate (β-OHB), a key ketone body, induces lysine β-hydroxybutyrylati…

Exploring therapeutic mechanism of Fuzhenghefuzhiyang Formula in psoriasis: inflammation and metabolism regulation Open

Chen Zhang, Yujie Yang, Haixin Zhong, Kexin Yang, Jingjie Yu , et al. · 2025

Background Psoriasis is a long-term, immune-mediated inflammatory disorder of the skin, affecting about 2-3% of the global population with rising prevalence rates. Clinical practice has demonstrated that Fuzhenghefuzhiyang formula (FZHFZY)…

HLA-B27 modulates the composition of the gut microbiota and drives a proinflammatory intestinal microecology Open

Siyu Chen, Cong Zhang, Ruo Chen, Pengfei Zhou, Zhuo-Cheng Li , et al. · 2025

The pathogenesis of autoimmune diseases such as spondyloarthritis (SpA), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD) involves genetic factors and gut microbiota dysbiosis, which have been widely reported in patients and…

Simultaneous excitation of dual fibers in a single channel for laser enucleation of the prostate: A case series and initial experience Open

Tianjie Li, Chen Zhang, Bo Xiao, Jianxing Li · 2025

Experimental study on the influence of PDA-modified PDMS on the biological behavior of mouse fibroblasts Open

T. J. Li, Chen Zhang, Diya Su, Jieqing Wang · 2025

Objective Polydimethylsiloxane (PDMS) is widely used across various fields due to its biocompatibility and chemical inertness. However, its surface hydrophobicity limits its application in cell culture. This study modifies PDMS surfaces wi…

Novel anti-LAG-3 antibody LBL-007 with anti-PD-1 blockade enhances antitumor immunity by promoting T cell-induced apoptosis Open

Kewei Qin, Huinan Zhou, Xiaojie Yu, Jianfei Liu, Chenglin Wu , et al. · 2025

Tracking Intra-annual plasticulture covering cycles using dense Sentinel-2 time-series Open

Chang Zhou, Mengya Zhao, Nuo Chen, Yuanyuan Du, Yuyang Huang , et al. · 2025

Plasticulture, a widespread practice using plastic covers (PCs) to enhance crop yields, has raised environmental concerns. Existing studies capture static PC distributions, leaving temporal dynamics uncharacterized and often missing season…

African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021 Open

Wang Qiuyun, Emmanuel Mensah, Zhichao Li, Deguo Wang, Chen Zhang , et al. · 2025

Aims Diabetes mellitus (DM), a chronic disease characterized by hyperglycemia, has become a global health concern. This study evaluates the burden of DM in the African region from 1990–2021 to inform prevention and control strategies. Meth…

Metabolic and Renal Profile Differences in Pure vs Mixed Uric Acid Kidney Stones: A Retrospective Study Open

Tianjie Li, Chen Zhang, Xiaodong Liu, Bo Xiao, Jianxing Li · 2025

Patients with PUCS exhibit more pronounced disturbances in lipid metabolism and renal function compared to those with MUCS. It is essential to prioritize and enhance the monitoring of metabolic assessments and renal function during the pos…

Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure Open

Jiaqi Wang, Yuwei Dong, Ruo‐Yi Xue, Yi Huang, Wu‐Bin Yang , et al. · 2025

Growing evidence indicates that immunological and metabolic outcomes are key mediators of long-term high-altitude exposure (LTHAE) adaption, but the underlying mechanisms remain poorly understood. This study employs plasma metabolomics and…

Relinqing Granules inhibiting lipopolysaccharide-induced pneumonia injury through modulation of the PI3K/AKT/mTOR signaling pathway Open

Yanyan Zhang, Dayi Liang, Lailai Li, Yilian Tang, Chen Zhang , et al. · 2025

RLQ effectively protected against LPS-induced lung and alveolar epithelial cell injury by inhibiting PI3K/AKT/mTOR pathway phosphorylation, restoring the Treg/Th17 immune balance, and suppressing apoptosis. These findings provide new mecha…

Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories Open

Lianglong Sun, Qin Wen, Xinyuan Liang, Caihong Wang, Weiwei Men , et al. · 2025

Human brain charts provide unprecedented opportunities for decoding neurodevelopmental milestones and establishing clinical benchmarks for precision brain medicine 1-7 . However, current lifespan brain charts are primarily derived from Eur…

The Influence Mechanism of the “Pinhaofan” Function on the Meituan Food Delivery Platform Open

Chen Zhang · 2025

Meituan Food Delivery innovates the takeout group purchase model through the “Pinhaofan” function. With its large user base and rapidly growing group purchase order volume, Meituan Food Delivery has demonstrated significant market potentia…

Study on Non-Destructive Testing Method of Existing Asphalt Pavement Based on the Principle of Geostatistics Open

Duanyi Wang, Chuanxi Luo, Chen Zhang, Wenting Zhang, Wenjie Xie · 2025

In the context of the rapid advancement of reconstruction and expansion projects, there has been a significant increase in the demand for the inspection and evaluation of existing asphalt pavements. In order to enhance the efficiency and e…

Targeting the Galectin‐7/TRPM2/Zn2+/DRP‐1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN Open

Chen Zhang, Bingyu Pang, Yi Luo, Zipeng Cao, Pei Qiao , et al. · 2025

Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a spectrum of severe drug‐induced cutaneous reactions. These conditions are characterized by widespread and confluent keratinocyte apoptosis, which di…

The delivery and transmembrane transport mechanism of SVCV nanovaccine Open

Han Zhang, Panpan Zhang, Xinxin Liu, Hai-Hua Peng, Qun Liu , et al. · 2025

Spring viremia of carp virus (SVCV) is a fatal microorganism for a variety of cyprinid fish species, sparking off enormous economic losses in freshwater fish aquaculture. For alleviating losses, immersion vaccination is an extremely promis…

Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations Open

Mei Yu, Chen Zhang, Zheng-Tong Wang, Shaowen Lv, Yi-Fang Sun , et al. · 2025

The predictive models enable clinicians to identify high-risk patients with coexisting mutations both preoperatively and postoperatively, supporting the development of individualized treatment strategies and potentially improving patient o…

Sequential Use of Apremilast, Total Glucosides of Paeony, and Periodontal Therapy in Refractory Plurimucosal Lichen Planus: A Case Report Open

Tao Yang, Zhenlai Zhu, Jiankang Yang, Mengmeng Song, Minghui Wei , et al. · 2025

Lichen planus (LP) is a chronic inflammatory disorder affecting mucosa and skin. This report presents a 61‐year‐old female with refractory LP involving buccal, gingival, and vulvovaginal mucosa, unresponsive to prior therapies including co…

Reconfigurable Multicomponent Plasmonic Hybrids for Promoting Photocatalytic H2o2 Production, Sers and Antibacterial in Tandem Open

Xiangming Li, Qingpeng Chen, Xingyong Yang, Zihan Yan, Lei Li , et al. · 2025

Remodeling of the Immune-Metabolic Landscape Triggered by Long-Term High-Altitude Exposure Open

Jiaqi Wang, Yuwei Dong, Ruo‐Yi Xue, Yi Huang, Wu‐Bin Yang , et al. · 2025

β-Hydroxybutyrate suppresses M1 macrophage polarization through β-hydroxybutyrylation of the STAT1 protein Open

Ya-ping Bai, Yujie Xing, Tao Ma, Kai Li, Teng Zhang , et al. · 2024

β-Hydroxybutyrate (β-OHB), the primary ketone body, is a bioactive metabolite that acts as both an energy substrate and a signaling molecule. Recent studies found that β-OHB inhibits the production of pro-inflammatory cytokines in macropha…

Bayesian inference of strangeon matter using the measurements of PSR J0437-4715 and GW190814 Open

W. L. Yuan, Chun Huang, Chen Zhang, Enping Zhou, Renxin Xu · 2024

The observations of compact star inspirals from LIGO/Virgo combined with mass and radius measurements from NICER provide a valuable tool to study the highly uncertain equation of state (EOS) of dense matter at the densities characteristic …

Blockade of CD73 potentiates radiotherapy antitumor immunity and abscopal effects via STING pathway Open

Ran An, Chao Wu, Cunyu Tang, Chen Zhang, Feiru Han , et al. · 2024

Radiotherapy (RT) is a crucial treatment for colorectal cancer (CRC) patients, but it often fails to induce systemic antitumor immunity. CD73, an immunomodulatory factor, is upregulated after RT and associated with poor prognosis in CRC pa…

Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells Open

Yongzhao Chen, Bo Jiang, Cheng Qu, Chaoyu Jiang, Chen Zhang , et al. · 2024

Introduction We aimed to comprehensively investigate the causal relationship between 731 immune cell traits and autoimmune thyroiditis (AIT) and to identify and quantify the role of 1400 metabolic traits as potential mediators in between. …

The high expression of ADRM1 in hepatocellular carcinoma is closely related to tumor immune infiltration and is regulated by miR-891a-5p Open

Ziqi Shao, Yuhui Yuan, Yuejun He, Chen Zhang, Yandong Zhao , et al. · 2024

Exosomal microRNAs in lung cancer: a narrative review Open

Zhe Zhang, Fengwu Lin, Wenqi Wu, Jingyuan Jiang, Chen Zhang , et al. · 2024

Exosomal miRNA can provide some unique ideas on how to improve the efficiency of diagnosis and treatment of lung cancer in the future. Targeting tumor-specific exosomal miRNA represents a new strategy for clinical treatment of lung cancer,…

Unveiling YWHAH: A potential therapeutic target for overcoming CD8+ T cell exhaustion in colorectal cancer Open

Qianfan Li, Yuan Zhao, Yuan Wang, Peng Zhai, Jian Wang , et al. · 2024

Colorectal cancer (CRC) is a significant global health challenge, with increasing rates of incidence and mortality. Despite advancements in immunotherapy, resistance, particularly due to T cell exhaustion, remains a major hurdle. This stud…

Association between non-scarring alopecia and hypothyroidism: a bidirectional two-sample Mendelian randomization study Open

Jiankang Yang, Zhenlai Zhu, Chen Zhang, Yanyang Guo, Gang Wang , et al. · 2024

Background Non-scarring alopecia is typically represented by two main types: alopecia areata (AA) and androgenetic alopecia (AGA). While previous observational studies have indicated a link between non-scarring alopecia and hypothyroidism,…

Comparative analysis of single-cell transcriptome reveals heterogeneity and commonality in the immune microenvironment of colorectal cancer and inflammatory bowel disease Open

Hongchao Lv, Yu Mu, Chen Zhang, Meiqi Zhao, Ping Jiang , et al. · 2024

Background During aging, chronic inflammation can promote tumor development and metastasis. Patients with chronic inflammatory bowel diseases (IBD) are at an increased risk of developing colorectal cancer (CRC). However, the molecular mech…

Marginal zone lymphoma with severe rashes: A case report Open

Si-Jun Bai, Ye Geng, Yi-Nan Gao, Cai‐Xia Zhang, Qian Mi , et al. · 2024

BACKGROUND Marginal zone lymphoma (MZL) is an indolent subtype of non-Hodgkin lymphoma (NHL), which is rare clinically with severe rashes as the initial symptom. CASE SUMMARY This study reports a case of MZL with generalized skin rashes ac…

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