Junxia Cao
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View article: Safety evaluation of cinacalcet: Signal mining and analysis of adverse events based on the FAERS database
Safety evaluation of cinacalcet: Signal mining and analysis of adverse events based on the FAERS database Open
Objective This study utilized the FDA Adverse Event Reporting System (FAERS) to assess signals of adverse events (AEs) associated with cinacalcet, aiming to enhance its safe and rational clinical application. Methods Adverse event reports …
View article: Safety evaluation of tucatinib: Adverse event signal mining and analysis based on the FAERS database
Safety evaluation of tucatinib: Adverse event signal mining and analysis based on the FAERS database Open
The purpose of this study was to evaluate the adverse events (AEs) associated with tucatinib by mining data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and explore potential drug-related AEs, thereby g…
View article: A Novel Scale System Based on the Frailty Index and Laboratory Indicators for the Short-Term Prognosis of Patients with Acute Myocardial Infarction: A Retrospective Cohort Study
A Novel Scale System Based on the Frailty Index and Laboratory Indicators for the Short-Term Prognosis of Patients with Acute Myocardial Infarction: A Retrospective Cohort Study Open
The novel prognostic assessment system, which integrates age, Stress Hyperglycemia Ratio (SHR), Neutrophil to Lymphocyte Ratio (NLR), lactate, and frailty score, exhibits good predictive value for short-term MACE in patients with acute myo…
View article: Intranasal inoculation of female BALB/c mice with replication-deficient human adenovirus type 5 expressing SARS-CoV‐2 nucleocapsid protein aggravates lung pathology upon re-encountering the antigen
Intranasal inoculation of female BALB/c mice with replication-deficient human adenovirus type 5 expressing SARS-CoV‐2 nucleocapsid protein aggravates lung pathology upon re-encountering the antigen Open
Preclinical studies indicate that SARS-CoV-2 nucleocapsid (N)-based vaccines, along with other viral protein(s), confer protection in various animal models against infection by SARS-CoV-2 ancestral virus and variants of concern. However, t…
View article: Fluoxetine partially alleviates inflammation in the kidney of socially stressed male <scp>C57 BL</scp> /6 mice
Fluoxetine partially alleviates inflammation in the kidney of socially stressed male <span>C57 BL</span> /6 mice Open
Stress‐related illnesses are linked to the onset and progression of renal diseases and depressive disorders. To investigate stress‐induced changes in the renal transcriptome associated with the development of depressive behaviors, we gener…
View article: Clinical efficacy analysis of mesenchymal stem cell therapy in patients with COVID-19: A systematic review
Clinical efficacy analysis of mesenchymal stem cell therapy in patients with COVID-19: A systematic review Open
Overall, our analysis suggests that while MSC therapy for COVID-19 patients does not significantly decrease inflammatory markers such as CRP, D-dimer and IL-6, OS is improved.
View article: Investigation of stress effect on creep, precipitation and dislocation evolution of Al–Li alloy during creep age forming
Investigation of stress effect on creep, precipitation and dislocation evolution of Al–Li alloy during creep age forming Open
The 3rd generation Al–Li alloy is a good candidate for large panel fabrication adopting creep age forming (CAF) because of its balanced synergy of high strength, good toughness, corrosion resistance and light weight. In this study, the cre…
View article: The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer Open
Lung cancer is one of the most prevalent cancers in both men and women worldwide. The nucleic acid G4 structures have been implicated in the transcriptional programmes of cancer-related genes in some cancers such as lung cancer. However, t…
View article: Development of an antibody-dependent cellular cytotoxicity reporter assay for measuring anti-Middle East Respiratory Syndrome antibody bioactivity
Development of an antibody-dependent cellular cytotoxicity reporter assay for measuring anti-Middle East Respiratory Syndrome antibody bioactivity Open
Middle East Respiratory Syndrome coronavirus (MERS-CoV) is a highly virulent pathogen that causes Middle East Respiratory Syndrome (MERS). Anti-MERS-CoV antibodies play an integral role in the prevention and treatment against MERS-CoV infe…
View article: RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog
RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog Open
Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive…
View article: The Memory about the Jewish Name in Thomas Hürlimanns Trilogy
The Memory about the Jewish Name in Thomas Hürlimanns Trilogy Open
As Assmann’s theory proves, the Literature plays an important role for the collective memories. It changes the discourse structure of society, by means of letting marginal, repressed or forgotten voice be read, heard and then finally hav…
View article: Smad4 inhibits cell migration via suppression of JNK activity in human pancreatic carcinoma PANC-1 cells
Smad4 inhibits cell migration via suppression of JNK activity in human pancreatic carcinoma PANC-1 cells Open
Smad4 is a common Smad and is a key downstream regulator of the transforming growth factor-β signaling pathway, in which Smad4 often acts as a potent tumor suppressor and functions in a highly context-dependent manner, particularly in panc…
View article: The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia
The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia Open
The first-in-class compound MLN4924 is a small molecule inhibitor that selectively inactivates NEDD8-activating enzyme (NAE). The anticancer effects of MLN4924 have been attributed to impaired neddylation of Cullin proteins. Here, we show …
View article: RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK
RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK Open
Autophagy is essential for maintaining tissue homeostasis. Although adaptors have been demonstrated to facilitate the assembly of the Atg14L-Beclin 1-Vps34-Vps15 complex, which functions in autophagosome formation, it remains unknown wheth…
View article: RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation
RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation Open
p38 mitogen-activated protein kinase (MAPK) activity has been reported to either promote or suppress cell death, which depends on cell type and stimulus. Our previous report indicates that p38 exerts a protective role in tumor necrosis fac…
View article: Evaluation of tumour vaccine immunotherapy for the treatment of advanced non-small cell lung cancer: a systematic meta-analysis
Evaluation of tumour vaccine immunotherapy for the treatment of advanced non-small cell lung cancer: a systematic meta-analysis Open
Objectives Our meta-analysis performed a systematic evaluation on the therapeutic efficacy and safety of tumour vaccines for the treatment of advanced non-small cell lung cancer (NSCLC). Design Systematic review and meta-analysis of random…