Explanipedia

The diagnostic value of hepatitis B core-related antigen in occult hepatitis B virus infection and its related hepatocellular carcinoma Open

Fuguo Zhan, Jiawei Zhang, Caorui Lin, Xiufeng Wu, Zhen Xun , et al. · 2025

HBcrAg is a promising serum marker for the diagnosis of OBI in HBsAg-negative population. HBcrAg is related to OBI-related HCC and is valuable in evaluating recurrence after radical resection surgery.

A novel therapy targeting the gut–liver axis for chronic hepatitis B: Ursodeoxycholic acid plus Bifidobacterium Open

Zhen Xun, Xiaobao Yao, Caorui Lin, Xinyao Yang, Yanfang Zhang , et al. · 2025

Characterization of BCP/PreC/C region quasispecies in treatment-naive patients with different phases of HBV infection using next-generation sequencing Open

Chenggong Zhu, Mingmin Tang, Ya Fu, Zhen Xun, Caorui Lin , et al. · 2024

Our research elucidates the evolution of HBV by analyzing QS heterogeneity and mutation patterns, offering novel serum biomarkers for enhancing clinical diagnosis and disease prognosis. This comprehensive approach sheds light on the intric…

Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes Open

Gang Han, Yao Zhang, Zhong Li, Biaobiao Wang, Shuai Qiu , et al. · 2024

Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and cellular internalization. Exosomes show potential as ideal delivery vehicles. However, an affordable generalizabl…

Multi-omics reveals deoxycholic acid modulates bile acid metabolism via the gut microbiota to antagonize carbon tetrachloride-induced chronic liver injury Open

Li Zhang, Zhiyi Zheng, Huanhuan Huang, Ya Fu, Tianbin Chen , et al. · 2024

Deoxycholic acid (DCA) serves essential functions in both physiological and pathological liver processes; nevertheless, the relationship among DCA, gut microbiota, and metabolism in chronic liver injury remain insufficiently understood. Th…

A novel <i>TRIM22</i> gene polymorphism promotes the response to PegIFNα therapy through cytokine-cytokine receptor interaction signaling pathway in chronic hepatitis B Open

Long Wang, Lin Ni, Yanfang Zhang, Shaoying Guo, Can Liu , et al. · 2023

Objectives: Pegylated interferon alfa (PegIFNα) has limited efficacy in patients with chronic hepatitis B (CHB). Because single-nucleotide polymorphisms (SNPs) are known to confer disease susceptibility and influence treatment response, we…

Oncostatin M Induces IFITM1 Expression to Inhibit Hepatitis B Virus Replication Via JAK-STAT Signaling Open

Yuchen Ye, FU Ya, Caorui Lin, Ye Shen, Qingqing Yu , et al. · 2023

Evaluating the value of anti-SARS-CoV-2 antibody detection and neutralizing responses with euvirus: A population of 10776 close contacts in the epidemic of Fujian Open

Yongbin Zeng, Caorui Lin, Can Liu, Huang Chun, Falin Chen , et al. · 2022

Effectiveness of SARS‐CoV‐2‐inactivated vaccine and the correlation to neutralizing antibodies: A test‐negative case–control study Open

Can Liu, Jiawei Zhang, Yongbin Zeng, Chun Huang, Falin Chen , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 breakthrough infection in highly vaccinated populations raises study on the effectiveness for inactivated vaccine, including effectiveness of the vaccine dose, the continuance of effectivenes…

Emerging role of mitochondria in response to <span>HBV</span> infection Open

Caorui Lin, Qishui Ou · 2022

Hepatitis B is a major global health problem that potentially life‐threatening liver infection caused by the hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). A considerable of rese…

Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury Open

Ning Ran, Wenxiang Li, Renjie Zhang, Caorui Lin, Jianping Zhang , et al. · 2022

Adenosine Triphosphate in Serum as a Promising Biomarker for Differential Diagnosis of Hepatitis B Disease Progression Open

Caorui Lin, Ying Huang, Linjie Luo, Fengling Fang, Jiawei Zhang , et al. · 2022

The need to be diagnosed with liver biopsy makes the clinical progression of chronic HBV infection diagnosis a challenge. Existing HBV serum biochemical assays are used throughout clinical but have limited effects. Studies have shown that …

Nomogram Model for Prediction of SARS-CoV-2 Breakthrough Infection in Fujian: A Case–Control Real-World Study Open

Tianbin Chen, Yongbin Zeng, Di Yang, Wenjing Ye, Jiawei Zhang , et al. · 2022

SARS-CoV-2 breakthrough infections have been reported because of the reduced efficacy of vaccines against the emerging variants globally. However, an accurate model to predict SARS-CoV-2 breakthrough infection is still lacking. In this ret…

Proteomic characterization of the natural history of chronic HBV infection revealed by tandem mass tag-based quantitative proteomics approach Open

Zhen Xun, Xiaobao Yao, Chenggong Zhu, Yuchen Ye, Songhang Wu , et al. · 2022

Cardio‐respiratory and phenotypic rescue of dystrophin/utrophin‐deficient mice by combination therapy Open

Caorui Lin, Gang Han, Lulu Jia, Yiwen Zhao, Jun Song , et al. · 2022

Upregulation of Wilms’ Tumor 1 in epicardial cells increases cardiac fibrosis in dystrophic mice Open

Zhenglong Guo, Mengyuan Geng, Yuting Huang, Gang Han, Renwei Jing , et al. · 2022

Evaluating the Value of Anti-SARS-CoV-2 Antibody Detection and Neutralizing Responses With Euvirus: A Population of 10776 Close Contacts in Delta Variant Epidemic of Fujian Open

Yongbin Zeng, Caorui Lin, Can Liu, Chun Huang, Falin Chen , et al. · 2022

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice Open

Ning Ran, Caorui Lin, Ling Leng, Gang Han, Mengyuan Geng , et al. · 2020

Antisense oligonucleotide (AO)-mediated exon-skipping therapies show promise in Duchenne muscular dystrophy (DMD), a devastating muscular disease caused by frame-disrupting mutations in the DMD gene. However, insufficient systemic delivery…

Fructose Promotes Uptake and Activity of Oligonucleotides with Different Chemistries in a Context-Dependent Manner in mdx Mice Open

Limin Cao, Gang Han, Caorui Lin, Ben J. Gu, Xianjun Gao , et al. · 2020

[This corrects the article DOI: 10.1038/mtna.2016.46.].

Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx Mice Open

Gang Han, Caorui Lin, Hanhan Ning, Xianjun Gao, HaiFang Yin · 2020

[This corrects the article DOI: 10.1016/j.omtn.2018.06.005.].

Glycine Enhances Satellite Cell Proliferation, Cell Transplantation, and Oligonucleotide Efficacy in Dystrophic Muscle Open

Caorui Lin, Gang Han, Hanhan Ning, Jun Song, Ning Ran , et al. · 2020

Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner Open

Gang Han, Ben J. Gu, Caorui Lin, Hanhan Ning, Jun Song , et al. · 2019

Insufficient delivery of oligonucleotides to muscle and heart remains a barrier for clinical implementation of antisense oligonucleotide (AO)-mediated exon-skipping therapeutics in Duchenne muscular dystrophy (DMD), a lethal monogenic diso…

Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx Mice Open

Gang Han, Caorui Lin, Hanhan Ning, Xianjun Gao, HaiFang Yin · 2018

[This corrects the article DOI: 10.1016/j.omtn.2018.06.005.].

Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice Open

Limin Cao, Gang Han, Caorui Lin, Ben J. Gu, Xianjun Gao , et al. · 2016

[This corrects the article DOI: 10.1038/mtna.2016.46.].

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