Cara Kosack
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View article: Correction: The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo
Correction: The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo Open
[This corrects the article DOI: 10.1371/journal.pone.0227773.].
View article: The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo
The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo Open
We found that computed radiography with teleradiology had significant clinical value in this resource-limited setting, with the potential to affect both patient outcomes and treatment costs through providing improved diagnostics and avoidi…
View article: NS1 antigen detecting assays for diagnosing acute dengue infection in people living in or returning from endemic countries
NS1 antigen detecting assays for diagnosing acute dengue infection in people living in or returning from endemic countries Open
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the diagnostic accuracy of commercial NS1 antigen detecting assays for acute dengue infection.
View article: Designing HIV Testing Algorithms Based on 2015 WHO Guidelines Using Data from Six Sites in Sub-Saharan Africa
Designing HIV Testing Algorithms Based on 2015 WHO Guidelines Using Data from Six Sites in Sub-Saharan Africa Open
Our objective was to evaluate the performance of HIV testing algorithms based on WHO recommendations, using data from specimens collected at six HIV testing and counseling sites in sub-Saharan Africa (Conakry, Guinea; Kitgum and Arua, Ugan…
View article: A guide to aid the selection of diagnostic tests
A guide to aid the selection of diagnostic tests Open
In recent years, a wide range of diagnostic tests has become available for use in resource-constrained settings. Accordingly, a huge number of guidelines, performance evaluations and implementation reports have been produced. However, this…
View article: Evaluation of a chest radiograph reading and recording system for tuberculosis in a HIV-positive cohort
Evaluation of a chest radiograph reading and recording system for tuberculosis in a HIV-positive cohort Open
This study demonstrated limited impact of the introduction of a CRRS on CXR accuracy and agreement amongst non-expert readers. The role in which CXRs are used for TB diagnosis in a HIV-positive cohort in similar clinical contexts should be…
View article: Towards more accurate HIV testing in sub‐Saharan Africa: a multi‐site evaluation of HIV RDTs and risk factors for false positives
Towards more accurate HIV testing in sub‐Saharan Africa: a multi‐site evaluation of HIV RDTs and risk factors for false positives Open
Introduction : Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use…
View article: Response to comment on “Alert, but not alarmed” – a comment on “Towards more accurate HIV testing in sub‐Saharan Africa: a multi‐site evaluation of HIV RDTs and risk factors for false positives (Kosack et al. 2017)”
Response to comment on “Alert, but not alarmed” – a comment on “Towards more accurate HIV testing in sub‐Saharan Africa: a multi‐site evaluation of HIV RDTs and risk factors for false positives (Kosack et al. 2017)” Open
Dear editors, We thank the respondents for their interest, and are glad that they agree overall with our findings and conclusions. We would like to emphasize that we reported [1] on the diagnostic accuracy of individual HIV rapid diagnosti…
View article: Additional files HIV diagnostic accuracy study
Additional files HIV diagnostic accuracy study Open
Additional files HIV diagnostic accuracy study
View article: Addfile 1 crude RDTs 04072016.pdf
Addfile 1 crude RDTs 04072016.pdf Open
Additional files to diagnostic accuracy study of HIV tests
View article: HIV misdiagnosis in sub‐Saharan Africa: performance of diagnostic algorithms at six testing sites
HIV misdiagnosis in sub‐Saharan Africa: performance of diagnostic algorithms at six testing sites Open
Introduction : We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub‐Saharan African countries. Methods : In this prospective multisite diagnostic evaluation study (Conakry, Guinea; Kitgum, Uganda; Ar…
View article: Point-of-care diagnostic tools : Selection, evaluation and implementation in resource-constrained settings
Point-of-care diagnostic tools : Selection, evaluation and implementation in resource-constrained settings Open
In recent year’s point-of-care diagnostic tools especially for the three main killer diseases HIV/AIDS, tuberculosis and malaria have been emerging on the market. This thesis examines the selection, evaluation and implementation of point-o…
View article: Evaluation of two rapid screening assays for detecting hepatitis C antibodies in resource‐constrained settings
Evaluation of two rapid screening assays for detecting hepatitis C antibodies in resource‐constrained settings Open
Objective To evaluate the diagnostic accuracy of the OraQuick HCV rapid antibody test from OraSure and the Multisure HCV antibody assay from MP Biomedicals. Methods Five seropanels from patients, intravenous drug users and blood donors wit…
View article: Implementing the Xpert® MTB/RIF Diagnostic Test for Tuberculosis and Rifampicin Resistance: Outcomes and Lessons Learned in 18 Countries
Implementing the Xpert® MTB/RIF Diagnostic Test for Tuberculosis and Rifampicin Resistance: Outcomes and Lessons Learned in 18 Countries Open
The implementation of Xpert was feasible and significantly increased TB detection compared to microscopy, despite the high rate of inconclusive results. Xpert implementation was accompanied by considerable operational and logistical challe…
View article: Errors generated by a point-of-care CD4+ T-lymphocyte analyser: a retrospective observational study in nine countries
Errors generated by a point-of-care CD4+ T-lymphocyte analyser: a retrospective observational study in nine countries Open
The Alere Pima CD4+ analyser generated a high proportion of invalid test results, across different countries, settings and users. Most error codes could be attributed to the operator, but the exact causes proved difficult to identify. Inva…
View article: Evaluation of the Nova StatSensor® XpressTM Creatinine Point-Of-Care Handheld Analyzer
Evaluation of the Nova StatSensor® XpressTM Creatinine Point-Of-Care Handheld Analyzer Open
Creatinine is a parameter that is required to monitor renal function and is important to follow in patients under treatment with potentially toxic renal drugs, such as the anti-HIV drug Tenofovir. A point of care instrument to measure crea…