Caren Yu-Ju Wu
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View article: TMIC-10. Analyzing Tumor Treating Fields (TTFields) therapy concomitantly with checkpoint inhibitors in a GBM mouse model
TMIC-10. Analyzing Tumor Treating Fields (TTFields) therapy concomitantly with checkpoint inhibitors in a GBM mouse model Open
Glioblastoma (GBM) is the most common malignant form of adult brain tumor, with a median survival of around 1.5-2 years. Despite multimodal treatments (tumor resection, radiotherapy, and chemotherapy) achieving an effective cure remains a …
View article: TMIC-13. Modification of the Sphingomyelin-Ceramide balance on the Cell Membrane of Tumor-Associated Myeloid Cells Affects Membrane Permeability
TMIC-13. Modification of the Sphingomyelin-Ceramide balance on the Cell Membrane of Tumor-Associated Myeloid Cells Affects Membrane Permeability Open
The poor prognosis of glioblastoma (GBM) mandates novel therapies. Despite the positive results of immunotherapy in many cancers, we have observed disappointing results with immunotherapy for GBM. Metabolic pathways, such as glycolysis, pl…
View article: 1243 Tumor associated myeloid cells facilitate cancer axonogenesis in glioblastoma
1243 Tumor associated myeloid cells facilitate cancer axonogenesis in glioblastoma Open
View article: Supplementary Data from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression
Supplementary Data from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression Open
Supplementary figures
View article: Data from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression
Data from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression Open
Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and high recurrence rates. The complex immune microenvironment of GBM is highly infiltrated by tumor-associated microglia and macrophages (TAM). TAMs are known to be…
View article: Supplementary Data from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression
Supplementary Data from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression Open
Supplementary figures
View article: Supplemental Materials and Methods from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression
Supplemental Materials and Methods from Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression Open
Supp M&M
View article: Figure S4 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Figure S4 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Figure S4: Ccr6-/- Tregs have reduced glycolysis compared to WT Tregs.
View article: Figure S3 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Figure S3 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Figure S3: Ccr6-/- Tregs are transcriptionally and metabolically distinct from WT Tregs.
View article: Figure S5 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Figure S5 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Figure S5: Ccr6 ablation reduces Treg immunosuppression of CD8 T cells in the context of tumor growth.
View article: Figure S2 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Figure S2 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Figure S2: CCR6 expression is enhanced in tumor-infiltrating Tregs co-expressing checkpoints and Ccr6 ablation reduces immunosuppressive phenotype.
View article: Figure S6 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Figure S6 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Figure S6: Ccr6 ablation delays tumor growth across multiple tumor models and CCR6CCL20 expression correlates with overall survival in cancer patients.
View article: Data from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Data from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Regulatory T cells (Treg) are important players in the tumor microenvironment. However, the mechanisms behind their immunosuppressive effects are poorly understood. We found that CCR6–CCL20 activity in tumor-infiltrating Tregs is associate…
View article: Figure S1 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Figure S1 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors Open
Figure S1: CCR6 and CCL20 expression is increased in multiple tumors.
View article: CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy Open
Immunotherapy has revolutionized the treatment of cancers. Reinvigorating lymphocytes with checkpoint blockade has become a cornerstone of immunotherapy for multiple tumor types, but the treatment of glioblastoma has not yet shown clinical…
View article: TMIC-38. MITOCHONDRIAL ATP BIOGENESIS REGULATED BY VDAC1 IN TMEM119+ TUMOR-ASSOCIATED MICROGLIA AND MACROPHAGES MEDIATES HIGH-GRADE GLIOMA GROWTH
TMIC-38. MITOCHONDRIAL ATP BIOGENESIS REGULATED BY VDAC1 IN TMEM119+ TUMOR-ASSOCIATED MICROGLIA AND MACROPHAGES MEDIATES HIGH-GRADE GLIOMA GROWTH Open
Patients with high-grade glioma have a poor prognosis and an average survival of less than 15 months, which is associated with an increase in tumor-associated microglia and macrophages (TAMs). TAMs in the glioma microenvironment are tradit…
View article: PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages
PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages Open
Stimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy in clinical trials. The mechanisms th…
View article: The Role of Myeloid Cells in GBM Immunosuppression
The Role of Myeloid Cells in GBM Immunosuppression Open
Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the most aggressive glioma type and resistant to immunotherapy, mainly due to its unique immune environment. Dimensional data analysis reveals that t…
View article: Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment
Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment Open
Human glioma facilitates an impaired anti-tumor immunity response, including defects in circulation of T lymphocytes. The level of CD8+ T-cell activation acts as an immune regulator associated with disease progression. However, …
View article: CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2
CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2 Open
Background Glioma-associated microglia/macrophages (GAMs) comprise macrophages of peripheral origin and brain-intrinsic microglia, which support tumor progression. Chemokine C-C ligand 5 (CCL5) is an inflammatory mediator produced by immun…
View article: Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells
Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells Open
Microglial activation has been widely demonstrated to mediate inflammatory processes that are crucial in several neurodegenerative disorders. Pharmaceuticals that can deliver direct inhibitory effects on microglia are therefore considered …