Carina Levin
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View article: Safety and pharmacodynamics of the ferroportin inhibitor vamifeport in patients with non-transfusion-dependent β-thalassemia: results from a randomized phase 2a study
Safety and pharmacodynamics of the ferroportin inhibitor vamifeport in patients with non-transfusion-dependent β-thalassemia: results from a randomized phase 2a study Open
Background Non-transfusion-dependent beta-thalassemia (β-NTDT) is characterized by ineffective erythropoiesis, increased intestinal iron absorption, and iron overload. The ferroportin inhibitor, vamifeport, has been shown to improve erythr…
View article: Hemoglobin A1C: Intracellular Heterogeneity and Functional Implications in Prediabetic and T2 Diabetic Erythrocytes
Hemoglobin A1C: Intracellular Heterogeneity and Functional Implications in Prediabetic and T2 Diabetic Erythrocytes Open
Hemoglobin A1C (HbA1C), a non-enzymatically glycated form of adult hemoglobin (HbA0), is a widely used biomarker for diabetes. Its concentration is strongly correlated with the long-term glycemic state and the risk of diabetes development.…
View article: Hemoglobin A1C: Intracellular Heterogeneity and Functional Implications in Prediabetic and T2 Diabetic Erythrocytes
Hemoglobin A1C: Intracellular Heterogeneity and Functional Implications in Prediabetic and T2 Diabetic Erythrocytes Open
Hemoglobin A1C (HbA1C), a non-enzymatically glycated form of adult hemoglobin (HbA0), is a widely used biomarker for diabetes. However, beyond its diagnostic role, its physiological functions remain poorly understood. To fill this gap, we …
View article: Cryo‐SEM in haematological research
Cryo‐SEM in haematological research Open
Cryogenic scanning electron microscopy (cryo‐SEM) is a powerful imaging technique used in cellular biology, providing high‐resolution micrographs that show the complexity and dynamics of biological systems. The use of high‐pressure freezin…
View article: <i>JK*01(307C)</i> encodes a <i>JK</i> null allele
<i>JK*01(307C)</i> encodes a <i>JK</i> null allele Open
View article: <i>Erratum to</i>: Characterization and genotype-phenotype correlation of patients with Fanconi anemia in a multi-ethnic population
<i>Erratum to</i>: Characterization and genotype-phenotype correlation of patients with Fanconi anemia in a multi-ethnic population Open
View article: Artificial intelligence-enabled non-invasive ubiquitous anemia screening: The HEMO-AI pilot study on pediatric population
Artificial intelligence-enabled non-invasive ubiquitous anemia screening: The HEMO-AI pilot study on pediatric population Open
Objective Determine whether data collected from a smartphone camera can be used to detect anemia in a pediatric population. Methods HEMO-AI (Hemoglobin Easy Measurement by Optical Artificial Intelligence), a clinical study carried out from…
View article: Iron Metabolism in Thalassemia and Sickle Cell Anemia: The influence of Genetic Modifiers
Iron Metabolism in Thalassemia and Sickle Cell Anemia: The influence of Genetic Modifiers Open
Iron metabolism plays a crucial role in the management of hemoglobinopathies, particularly in conditions such as β-thalassemia and sickle cell anemia (SCA). This paper describes the mechanisms of iron overload in patients with transfusion-…
View article: Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening
Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening Open
The blood counts of α thalassemia carriers (α-thal) are similar to those of β thalassemia carriers, except for Hemoglobin A2 (Hb A2), which is not elevated. The objective of this study was to determine whether mathematical formulas are eff…
View article: A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome
A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome Open
We investigated efficacy and safety of mavorixafor, an oral CXCR4 antagonist, in participants with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency caused by CXCR4 gain-of-function varian…
View article: Symptomatic corpus luteum hemorrhage in adolescent females with ITP
Symptomatic corpus luteum hemorrhage in adolescent females with ITP Open
View article: Genetic backgrounds and clinical characteristics of congenital neutropenias in <scp>Israel</scp>
Genetic backgrounds and clinical characteristics of congenital neutropenias in <span>Israel</span> Open
Background Congenital neutropenias are characterized by severe infections and a high risk of myeloid transformation; the causative genes vary across ethnicities. The Israeli population is characterized by an ethnically diverse population w…
View article: Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path Toward Universal Screening
Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path Toward Universal Screening Open
The blood counts of α thalassemia carriers (α-thal) are similar to those of β thalassemia carriers, except for Hgb A2 that is not elevated. The objective of this study was to determine whether mathematical formulas are effective for detect…
View article: The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human Erythrocytes
The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human Erythrocytes Open
The membrane-bound hemoglobin (Hb) fraction impacts red blood cell (RBC) rheology and metabolism. Therefore, Hb–RBC membrane interactions are precisely controlled. For instance, the signaling function of membrane-bound deoxy-Hb and the str…
View article: Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome Open
STAT3 GOF patients present with a wide array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisystem autoimmunity. Patient care tends to be siloed, without a clear treatment strategy. Thus, early id…
View article: The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism
The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism Open
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia, and progressive organ failure. Chronic inflammatory state …
View article: Associations between red blood cell indices and iron status and neurocognitive function in young adults: Evidence from memory and executive function tests and event‐related potentials
Associations between red blood cell indices and iron status and neurocognitive function in young adults: Evidence from memory and executive function tests and event‐related potentials Open
Cognitive impairment has been associated with anemia and iron deficiency; however, brain electrophysiological studies correlating red blood cell (RBC) indices and iron status to cognition in adulthood are scarce. We aimed to assess neuroco…
View article: BACK TO THE “GOLD STANDARD”: HOW PRECISE IS HEMATOCRIT DETECTION TODAY?
BACK TO THE “GOLD STANDARD”: HOW PRECISE IS HEMATOCRIT DETECTION TODAY? Open
Introduction: The commonly used method for hematocrit detection, by visual examination of microcapillary tube, known as "micro-HCT", is subjective but still remains one of the key sources for false hematocrit evaluation. Analytical automat…
View article: P817: SYNDROMES PREDISPOSING TO LEUKEMIA ARE A MAJOR CAUSE OF INHERITED CYTOPENIAS IN CHILDREN
P817: SYNDROMES PREDISPOSING TO LEUKEMIA ARE A MAJOR CAUSE OF INHERITED CYTOPENIAS IN CHILDREN Open
Background: Prolonged cytopenias are a non-specific sign with a wide differential diagnosis. Among inherited disorders, cytopenias predisposing to leukemia require a timely and accurate diagnosis to ensure appropriate medical management, i…
View article: PB1938: 4WHIM: EVALUATING MAVORIXAFOR, AN ORAL CXCR4 ANTAGONIST, IN PATIENTS WITH WHIM SYNDROME VIA A GLOBAL PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED TRIAL WITH OPEN-LABEL EXTENSION
PB1938: 4WHIM: EVALUATING MAVORIXAFOR, AN ORAL CXCR4 ANTAGONIST, IN PATIENTS WITH WHIM SYNDROME VIA A GLOBAL PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED TRIAL WITH OPEN-LABEL EXTENSION Open
Background: Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a primary immunodeficiency characterized by retention of leukocytes in the bone marrow (myelokathexis), resulting in neutropenia, leukopenia, and in…
View article: PB2222: THE PROTECTIVE EFFECT OF THE SPLEEN IN SICKLE CELL PATIENTS. A COMPARATIVE STUDY BETWEEN PATIENTS WITH ASPLENIA AND HYPERSPLENISM.
PB2222: THE PROTECTIVE EFFECT OF THE SPLEEN IN SICKLE CELL PATIENTS. A COMPARATIVE STUDY BETWEEN PATIENTS WITH ASPLENIA AND HYPERSPLENISM. Open
Background: Sickle cell disease (SCD) is caused by a point mutation in the beta globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia and progressive organ failure. A chronic inflam…
View article: Syndromes predisposing to leukemia are a major cause of inherited cytopenias in children
Syndromes predisposing to leukemia are a major cause of inherited cytopenias in children Open
Prolonged cytopenias are a non-specific sign with a wide differential diagnosis. Among inherited disorders, cytopenias predisposing to leukemia require a timely and accurate diagnosis to ensure appropriate medical management, including ade…
View article: A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia
A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia Open
Excessive intravascular release of lysed cellular contents from damaged red blood cells (RBCs) in patients with sickle cell anemia (SCA) can activate the inflammasome, a multiprotein oligomer promoting maturation and secretion of proinflam…
View article: Characterization of acquired anemia in children by iron metabolism parameters
Characterization of acquired anemia in children by iron metabolism parameters Open
View article: Renal function in β-thalassemia major patients treated with two different iron-chelation regimes
Renal function in β-thalassemia major patients treated with two different iron-chelation regimes Open
Background Renal injury in transfusion dependent β thalassemia patients (TDT) has been attributed to iron overload, chronic anemia and iron-chelation therapy (ICT) toxicity. We studied renal function in TDT patients treated with two differ…
View article: Extracellular Vesicle MicroRNA That Are Involved in β-Thalassemia Complications
Extracellular Vesicle MicroRNA That Are Involved in β-Thalassemia Complications Open
Beta thalassemia major (βT) is a hereditary anemia characterized by transfusion-dependency, lifelong requirement of chelation, and organ dysfunction. MicroRNA (miRNA) can be packed into extracellular vesicles (EVs) that carry them to targe…
View article: Resolution of Unexplained Iron Deficiency Following Successful Eradication of Helicobacter Pylori in Children
Resolution of Unexplained Iron Deficiency Following Successful Eradication of Helicobacter Pylori in Children Open
Background: Evidence is needed to inform whether Helicobacter pylori (HP) treatment is beneficial in children with refractory iron deficiency. We aimed to assess association between successful HP eradication and resolution of unexplained i…
View article: Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions?
Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions? Open
Red blood cell (RBC) transfusion is one of the most common therapeutic procedures in modern medicine. Although frequently lifesaving, it often has deleterious side effects. RBC quality is one of the critical factors for transfusion efficac…
View article: Renal Function in β-Thalassemia Major Patients Treated with Two Different Iron-Chelation Regimes.
Renal Function in β-Thalassemia Major Patients Treated with Two Different Iron-Chelation Regimes. Open
Background: Renal injury in Transfusion dependent β thalassemia patients (TDT) has been attributed to iron overload, chronic anemia and iron-chelation therapy (ICT) toxicity. We studied renal function in TDT patients treated with two diffe…
View article: Primary autoimmune myelofibrosis: A case report in a child
Primary autoimmune myelofibrosis: A case report in a child Open
Autoimmune myelofibrosis (AIMF) is an uncommon cause of myelofibrosis associated with favorable outcome. Primary AIMF, AIMF without a known systemic autoimmune disorder, has been described in adults, but never in children. Here, we present…