Carl A. Mitchell
YOU?
Author Swipe
View article: Maternal IL-10 restricts fetal emergency myelopoiesis
Maternal IL-10 restricts fetal emergency myelopoiesis Open
SUMMARY Neonates, in contrast to adults, are highly susceptible to inflammation and infection. Here we investigate how late fetal liver (FL) mouse hematopoietic stem and progenitor cells (HSPC) respond to inflammation, testing the hypothes…
View article: Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells
Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells Open
Aging of the hematopoietic system promotes various blood, immune and systemic disorders and is largely driven by hematopoietic stem cell (HSC) dysfunction ( 1 ). Autophagy is central for the benefits associated with activation of longevity…
View article: Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production Open
Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production and control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors to ste…
View article: Stromal inflammation is a targetable driver of hematopoietic aging
Stromal inflammation is a targetable driver of hematopoietic aging Open
Hematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to impaired blood production. Signals from the bone marrow (BM) niche tailor blood production, but the …
View article: Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis Open
Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor cells to dynamically replenish myeloid lineage cells i…
View article: Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions Open
While young blood can restore many aged tissues, its effects on the aged blood system itself and old hematopoietic stem cells (HSCs) have not been determined. Here, we used transplantation, parabiosis, plasma transfer, exercise, calorie re…
View article: Stromal inflammation is a targetable driver of hematopoietic aging
Stromal inflammation is a targetable driver of hematopoietic aging Open
Hematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to dysfunctional blood production. Signals from the bone marrow (BM) niche dynamically tailor hematopoi…
View article: Reading frame restoration at the EYS locus, and allele-specific chromosome removal after Cas9 cleavage in human embryos
Reading frame restoration at the EYS locus, and allele-specific chromosome removal after Cas9 cleavage in human embryos Open
Summary The correction of disease-causing mutations in human embryos could reduce the burden of inherited genetic disorders in the fetus and newborn, and improve the efficiency of fertility treatments for couples with disease-causing mutat…