Carl E Darris
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View article: Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptation
Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptation Open
Collagen IV (Col-IV) is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epithelial tissues. In mammals, Col-IV assembles from a family of six α-chains (α1-α6), …
View article: Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling animal evolution and adaptation
Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling animal evolution and adaptation Open
Collagen IV is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epithelial tissues. In mammals, collagen IV assembles from a family of six α-chains (α1 to α6), f…
View article: Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein
Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein Open
The emergence of the basement membrane (BM), a specialized form of extracellular matrix, was essential in the unicellular transition to multicellularity. However, the mechanism is unknown. Goodpasture antigen-binding protein (GPBP), a BM p…
View article: A comparative analysis of microbial profile of Guinea fowl and chicken using metagenomic approach
A comparative analysis of microbial profile of Guinea fowl and chicken using metagenomic approach Open
Probiotics are live microbial feed supplements that promote growth and health to the host by minimizing non-essential and pathogenic microorganisms in the host's gastrointestinal tract (GIT). The campaign to minimize excessive use of antib…
View article: Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues
Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues Open
The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary…
View article: Author response: Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues
Author response: Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The role of the cellular microenvironment in en…
View article: Lysine mediation of neuroendocrine food regulation in guinea fowl
Lysine mediation of neuroendocrine food regulation in guinea fowl Open
In poultry, obesity is partly influenced by food intake, and is increasingly becoming a nationwide problem. Hypothalamic food intake mechanisms are involved metabolically and neurologically via two peptide hormones, leptin and ghrelin, and…
View article: Molecular tools to support metabolic and immune function research in the Guinea Fowl (Numida meleagris)
Molecular tools to support metabolic and immune function research in the Guinea Fowl (Numida meleagris) Open
The transcriptome information presented here will support the development of molecular approaches to improve production efficiency of the guinea fowl and other avian species.
View article: Hypohalous Acids Contribute to Renal Extracellular Matrix Damage in Experimental Diabetes
Hypohalous Acids Contribute to Renal Extracellular Matrix Damage in Experimental Diabetes Open
In diabetes, toxic oxidative pathways are triggered by persistent hyperglycemia and contribute to diabetes complications. A major proposed pathogenic mechanism is the accumulation of protein modifications that are called advanced glycation…