Carl F. Ware
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View article: iBALT formation in the absence of lymphotoxin is protective in a lung β-coronavirus infection model 3230
iBALT formation in the absence of lymphotoxin is protective in a lung β-coronavirus infection model 3230 Open
Description The lymphotoxin signaling pathway mediates various immune responses, from lymph node organogenesis to dendritic cell homeostasis and differentiation of interferon-producing cells in response to pathogens. We investigated the ly…
View article: Simultaneous activation of STING and lymphotoxin β receptor potentiates immune checkpoint inhibition and prevents tumor recurrence and metastasis by inducing germinal center B cell responses in TLS 4774
Simultaneous activation of STING and lymphotoxin β receptor potentiates immune checkpoint inhibition and prevents tumor recurrence and metastasis by inducing germinal center B cell responses in TLS 4774 Open
Description We found that simultaneous activation of innate immune effectors, STING and lymphotoxin-b receptor (LTbR), using their agonists induces intratumoral germinal center B cell responses to generate functional TLS in mouse tumors. S…
View article: Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity Open
View article: Quantitative detection of the HVEM-BTLA checkpoint receptor <i>cis</i>-complex in human lymphocytes
Quantitative detection of the HVEM-BTLA checkpoint receptor <i>cis</i>-complex in human lymphocytes Open
The herpesvirus entry mediator (HVEM) (TNFRSF14) engagement of the checkpoint inhibitory receptor B and T lymphocyte attenuator (BTLA) limits immune responses of T and B lymphocytes. HVEM and BTLA form signaling complexes in trans and when…
View article: Myofibroblast Programming Blocks Differentiation of TLS-Organizing Fibroblastic Reticular Cells in Pancreatic Cancer
Myofibroblast Programming Blocks Differentiation of TLS-Organizing Fibroblastic Reticular Cells in Pancreatic Cancer Open
View article: 1007 Modulating CAF phenotypes in pancreatic cancer to enhance formation of tertiary lymphoid structures
1007 Modulating CAF phenotypes in pancreatic cancer to enhance formation of tertiary lymphoid structures Open
View article: Ethical challenges in integrating social robots in geriatric care: Development and assessment of an educational module for health and social care professionals
Ethical challenges in integrating social robots in geriatric care: Development and assessment of an educational module for health and social care professionals Open
View article: Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA Open
View article: Figure S7 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S7 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Impact of Treg depletion and LTβR agonist treatment on the immune cell organisation in fibrosarcoma tumours.
View article: Supplementary Movie 1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Supplementary Movie 1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in a 4T1 regressor tumour following PI-3065 treatment.
View article: Figure S1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
2D assessment of fibrosarcoma establishment on LN HEVs
View article: Figure S1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
2D assessment of fibrosarcoma establishment on LN HEVs
View article: Supplementary Movie 2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Supplementary Movie 2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in a 4T1 regressor tumour following PI-3065 treatment.
View article: Figure S6 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S6 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in 4T1 tumours following PI-3065 treatment.
View article: Figure S3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Impact of Treg depletion on LN HEV remodelling
View article: Supplementary Movie 2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Supplementary Movie 2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in a 4T1 regressor tumour following PI-3065 treatment.
View article: Data from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Data from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
High endothelial venules (HEV) are specialized post capillary venules that recruit naïve T cells and B cells into secondary lymphoid organs (SLO) such as lymph nodes (LN). Expansion of HEV networks in SLOs occurs following immune activatio…
View article: Figure S6 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S6 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in 4T1 tumours following PI-3065 treatment.
View article: Figure S4 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S4 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
LSFM imaging of Treg depleted fibrosarcomas.
View article: Figure S5 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S5 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
LSFM imaging of Treg depleted and T-cell depleted fibrosarcomas.
View article: Figure S3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Impact of Treg depletion on LN HEV remodelling
View article: Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in a 4T1 non-regressor tumour following PI-3065 treatment.
View article: Figure S4 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S4 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
LSFM imaging of Treg depleted fibrosarcomas.
View article: Figure S5 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S5 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
LSFM imaging of Treg depleted and T-cell depleted fibrosarcomas.
View article: Data from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Data from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
High endothelial venules (HEV) are specialized post capillary venules that recruit naïve T cells and B cells into secondary lymphoid organs (SLO) such as lymph nodes (LN). Expansion of HEV networks in SLOs occurs following immune activatio…
View article: Figure S2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Naïve LN HEV Characterisation.
View article: Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in a 4T1 non-regressor tumour following PI-3065 treatment.
View article: Figure S2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Naïve LN HEV Characterisation.
View article: Figure S7 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Figure S7 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Impact of Treg depletion and LTβR agonist treatment on the immune cell organisation in fibrosarcoma tumours.
View article: Supplementary Movie 1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Supplementary Movie 1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells Open
Global overview of intra-tumoral HEVs in a 4T1 regressor tumour following PI-3065 treatment.