Carl Friedrich Classen
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View article: Targeting PP2A in cancer: an underrated option
Targeting PP2A in cancer: an underrated option Open
View article: Temozolomide-based radio-chemotherapy for newly diagnosed pediatric high-grade gliomas (HIT-HGG-2007): A prospective, multicenter, single-arm, phase II trial
Temozolomide-based radio-chemotherapy for newly diagnosed pediatric high-grade gliomas (HIT-HGG-2007): A prospective, multicenter, single-arm, phase II trial Open
Background: The HIT-HGG-2007 trial investigated temozolomide (TMZ) radio-chemotherapy for pediatric patients with high-grade gliomas (pHGG) to demonstrate therapeutic non-inferiority compared to previous intensive radio-chemotherapy regime…
View article: Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland
Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland Open
Background Invasive fungal diseases (IFD) pose significant challenges in paediatric oncology. Their management is complicated by limited paediatric‐specific evidence, lack of standardised protocols and variability in resources across centr…
View article: Inflammation-based score in pediatric adrenocortical carcinoma
Inflammation-based score in pediatric adrenocortical carcinoma Open
Inflammation-based scores have been demonstrated to be independent prognostic factors in predicting outcomes in adult adrenocortical carcinoma (ACC). We aimed to investigate the prognostic role of these scores in pediatric adrenocortical c…
View article: On <scp>TRacK</scp> With Larotrectinib in a Neonate With a Giant Congenital <i>ETV6::NTRK3</i> Fusion‐Positive Infantile Fibrosarcoma of the Head and Neck
On <span>TRacK</span> With Larotrectinib in a Neonate With a Giant Congenital <i>ETV6::NTRK3</i> Fusion‐Positive Infantile Fibrosarcoma of the Head and Neck Open
Background Infantile fibrosarcoma (IFS) is a rare pediatric tumor of intermediate malignancy with high local aggressiveness that typically presents in young infants. Its occurrence in the head and neck region is rare. Complete non‐mutilati…
View article: A Multimodal Lifestyle Psychosocial Survivorship Program in Young Cancer Survivors
A Multimodal Lifestyle Psychosocial Survivorship Program in Young Cancer Survivors Open
Importance There is a lack of trials examining the effect of counseling interventions for child, adolescent, and younger adult (CAYA) cancer survivors. Objective To assess lifestyle habits and the psychosocial situation of CAYAs to determi…
View article: NUT carcinoma in pediatric patients: Characteristics, therapeutic regimens, and outcomes of 11 cases registered with the German Registry for Rare Pediatric Tumors (STEP)
NUT carcinoma in pediatric patients: Characteristics, therapeutic regimens, and outcomes of 11 cases registered with the German Registry for Rare Pediatric Tumors (STEP) Open
Background and aims Nuclear protein of the testis (NUT) carcinoma (NC) is a rare and highly aggressive tumor defined by the presence of a somatic NUTM1 rearrangement, occurring mainly in adolescents and young adults. We analyzed the clinic…
View article: Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells Open
Glioblastoma is the most common primary brain cancer in adults and represents one of the worst cancer diagnoses for patients. Suffering from a poor prognosis and limited treatment options, tumor recurrences are virtually inevitable. Additi…
View article: The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C Open
Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in precli…
View article: Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells
Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells Open
Constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy are hallmarks of Glioblastoma multiforme (GBM). The latter metabolic defect renders tumor cells vulnerable to arginine-depleting substances, such as arginine…
View article: Integrative medicine during the intensive phase of chemotherapy in pediatric oncology in Germany: a randomized controlled trial with 5-year follow up
Integrative medicine during the intensive phase of chemotherapy in pediatric oncology in Germany: a randomized controlled trial with 5-year follow up Open
View article: HGG-13. Combined CDK inhibition and arginine-deprivation as targeted therapy for arginine-auxotrophic glioblastoma multiforme cells
HGG-13. Combined CDK inhibition and arginine-deprivation as targeted therapy for arginine-auxotrophic glioblastoma multiforme cells Open
INTRODUCTION/BACKGROUND: Glioblastoma multiforme show constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy. This renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase …
View article: The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification
The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification Open
Glioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal prognosis. One frequent, putative driver mutation is the genomic amplification of the oncogenic rec…
View article: Secondary Biphenotypic Acute Leukemia Following Rosai-Dorfman-Disease A Coincidence?
Secondary Biphenotypic Acute Leukemia Following Rosai-Dorfman-Disease A Coincidence? Open
Abbreviations RDD Rosai-Dorfman-Disease TP53 Tumor protein p53 CNS Central nervous system Dexa dexamethasone ESR Erythrocyte sedimentation rate IC-2 Initial Course 2 of LCH-registry Therapy (Vinblastine and Prednisolone)LCH-registry Intern…
View article: Splenomegaly in Children and Adolescents
Splenomegaly in Children and Adolescents Open
In contrast to other lymphoid tissues making up the immune system, the spleen as its biggest organ is directly linked into the blood circulation. Beside its main task to filter out microorganism, proteins, and overaged or pathologically al…
View article: Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations Open
View article: Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2D and 3D glioblastoma cell culture models
Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2D and 3D glioblastoma cell culture models Open
View article: HGG-07. CYCLIN-DEPENDENT KINASES AS TARGET STRUCTURES FOR CANCER THERAPY – A COMPARATIVE IN VITRO ANALYSIS ON PATIENT-DERIVED GLIOBLASTOMA CELL CULTURE MODELS
HGG-07. CYCLIN-DEPENDENT KINASES AS TARGET STRUCTURES FOR CANCER THERAPY – A COMPARATIVE IN VITRO ANALYSIS ON PATIENT-DERIVED GLIOBLASTOMA CELL CULTURE MODELS Open
INTRODUCTION Current therapeutic approaches have limited clinical success for Glioblastoma patients, making novel strategies urgent. Cyclin-dependent kinases (CDK) are crucial in cell cycle, oncogenic transcription, DNA repair, and stem-ce…
View article: Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib
Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib Open
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer…
View article: Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review
Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review Open
Background Improved, multimodal treatment strategies have been shown to increase cure rates in cancer patients. Those who survive cancer as a child, adolescent or young adult (CAYA), are at a higher risk for therapy-, or disease-related, l…
View article: Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series
Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series Open
Background Data on frequency, clinical presentation, and outcome of primary metastatic intracranial ependymoma in children are scarce. Patients and Methods Prospective data on patients younger than 21 years with metastatic intracranial epe…
View article: HGG-32. ARG-AUXOTROPHIC PATIENT-DERIVED GLIOBLASTOMA MULTIFORME CELL LINES SHOW INCREASED SENSITIVITY TOWARDS DOXYCYCLINE-INDUCED GROWTH INHIBITION
HGG-32. ARG-AUXOTROPHIC PATIENT-DERIVED GLIOBLASTOMA MULTIFORME CELL LINES SHOW INCREASED SENSITIVITY TOWARDS DOXYCYCLINE-INDUCED GROWTH INHIBITION Open
Arginine auxotrophy constitutes a metabolic defect that renders tumors susceptible towards arginine-depleting substances, such as bacterial arginine deiminase (ADI). In our previous studies, Arg auxotrophy and thus ADI-susceptibility was c…
View article: Adolescents and young adults with cancer: aspects of adherence &ndash; a questionnaire study
Adolescents and young adults with cancer: aspects of adherence – a questionnaire study Open
Our findings confirm the need for more focused approaches to serve the special needs of AYAs, with particular attention on specific items that showed up discriminating AYAs from older patients, that is, Internet use and communication with …
View article: Temozolomide-induced increase of tumorigenicity can be diminished by targeting of mitochondria in in vitro models of patient individual glioblastoma
Temozolomide-induced increase of tumorigenicity can be diminished by targeting of mitochondria in in vitro models of patient individual glioblastoma Open
Glioblastoma multiforme (GBM) is a highly heterogeneous and aggressive brain tumor with a dismal prognosis. Development of resistance towards cytostatic drugs like the GBM standard drug temozolomide is a severe problem in GBM treatment. On…
View article: Supplementary Material for: Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies
Supplementary Material for: Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies Open
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a…
View article: Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies
Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies Open
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosi…
View article: Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme
Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme Open
Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults. It is known that amplification of the epidermal growth factor receptor gene (EGFR) occurs in approximately 40% of GBM, leading to enhanced activation of the…
View article: EPN-20NEWLY DIAGNOSED METASTATIC INTRACRANIAL EPENDYMOMA IN CHILDREN: FREQUENCY, TREATMENT AND OUTCOME IN THE POPULATION BASED, PROSPECTIVE HIT-SERIES
EPN-20NEWLY DIAGNOSED METASTATIC INTRACRANIAL EPENDYMOMA IN CHILDREN: FREQUENCY, TREATMENT AND OUTCOME IN THE POPULATION BASED, PROSPECTIVE HIT-SERIES Open
View article: HG-10IN VITRO MODELS OF GLIOBLASTOMA MULTIFORME - CHARACTERISTICS OF CANCER STEM CELLS
HG-10IN VITRO MODELS OF GLIOBLASTOMA MULTIFORME - CHARACTERISTICS OF CANCER STEM CELLS Open
View article: HG-13GLIOBLASTOMA TUMOR CELLS ACHIEVE CANCER STEM-LIKE CELL PROPERTIES AFTER TEMOZOLOMIDE TREATMENT
HG-13GLIOBLASTOMA TUMOR CELLS ACHIEVE CANCER STEM-LIKE CELL PROPERTIES AFTER TEMOZOLOMIDE TREATMENT Open