Explanipedia

Kidney transplant rejection despite zero eplet DR / DQ mismatch: A case report Open

Artur Quintiliano Bezerra da Silva, Carl H. Cramer, Andrew Bentall, Mikel Prieto, Samih H. Nasr , et al. · 2025

Eplet mismatch (MM) quantification is a valuable tool for refining histocompatibility in kidney transplantation, especially at HLA-DR/DQ loci. However, zero MM at these loci does not ensure complete immunological safety. We report a 17-yea…

Functional Analysis of a De Novo Monoallelic NEK8 Variant Supports Pathogenicity for a Polycystic Kidney Disease Phenotype Open

Whitney S. Thompson, Chuan Chen, Hana Yang, Theodora A. Potretzke, Tania A. Baker , et al. · 2025

P201: The clinical utility of next-generation sequencing (NGS)-based genetic testing in pediatric polycystic kidney disease Open

Engin Bozkurt, Hana Yang, Jennifer L. Kemppainen, Tracy J. Baker, Mohamad Sheikh Najeeb , et al. · 2025

Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study Open

Chia-shi Wang, Dorey A. Glenn, Margaret Helmuth, Abigail R. Smith, Andrew S. Bomback , et al. · 2023

Early post-transplant recurrence of ANCA vasculitis while on belatacept maintenance immunosuppression Open

Amogh Agrawal, Grace Y. Chong, Mary E. Fidler, Carl H. Cramer, Hatem Amer , et al. · 2023

Post-transplant recurrence of ANCA-associated vasculitis (AAV) is infrequent, with recurrence within weeks of transplantation being even rarer. We describe an unusual case of AAV recurrence within 2 weeks post-transplant. Our patient recei…

Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network Open

Dhruti P. Chen, Margaret Helmuth, Abigail R. Smith, Pietro A. Canetta, Isabelle Ayoub , et al. · 2023

Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease Open

Jill Krissberg, Michelle M. O’Shaughnessy, Abigail R. Smith, Margaret Helmuth, Salem Almaani , et al. · 2022

Phase 3 trial of lumasiran for primary hyperoxaluria type 1: A new RNAi therapeutic in infants and young children Open

David J. Sas, Daniella Magen, Wesley Hayes, Hadas Shasha‐Lavsky, Mini Michael , et al. · 2021

Lumasiran showed rapid, sustained reduction in spot UOx:Cr and plasma oxalate and acceptable safety in patients aged <6 years with PH1, establishing RNA interference therapies as safe, effective treatment options for infants and young chil…

New-onset cough and fever in a toddler with stage 5 chronic kidney disease: Questions Open

C Petri, Yalile Perez, Leah S. Heidenreich, Carl H. Cramer, Timothy M. Olson , et al. · 2021

A Framework for Outpatient Infusion of Antispike Monoclonal Antibodies to High-Risk Patients with Mild-to-Moderate Coronavirus Disease-19 Open

Raymund R. Razonable, Nicole C.E. Aloia, Ryan J. Anderson, Gokhan Anil, Lori L. Arndt , et al. · 2021

Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study Open

Shannon L. Murphy, John D. Mahan, Jonathan P. Troost, Tarak Srivastava, Amy J. Kogon , et al. · 2020

Using a Modified CPD Blood Bag to Store Blood from either ECMO or RRT Circuit Blood in Pediatric Patients Open

James R. Neal, Tammy Friedrich, Gregory J. Schears, Carl H. Cramer · 2020

By adapting a citrate phosphate dextrose (CPD) whole blood storage bag, residual blood from a renal replacement therapy (RRT) circuit can be saved in pediatric patients, decreasing in donor exposure later. The techniques used for autologou…

Using a Modified CPD Blood Bag to Store Blood from either ECMO or RRT Circuit Blood in Pediatric Patients. Open

James R. Neal, Tammy Friedrich, Gregory J. Schears, Carl H. Cramer · 2020

By adapting a citrate phosphate dextrose (CPD) whole blood storage bag, residual blood from a renal replacement therapy (RRT) circuit can be saved in pediatric patients, decreasing in donor exposure later. The techniques used for autologou…

Persistent Disease Activity in Patients With Long-Standing Glomerular Disease Open

Elisa Delbarba, Maddalena Marasà, Pietro A. Canetta, Stacy Piva, Debanjana Chatterjee , et al. · 2020

Health-related quality of life in glomerular disease Open

Pietro A. Canetta, Jonathan P. Troost, Shannon Mahoney, Amy J. Kogon, Noelle E. Carlozzi , et al. · 2019

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease Open

Laura Mariani, Andrew S. Bomback, Pietro A. Canetta, Michael F. Flessner, Margaret Helmuth , et al. · 2018

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study Open

David T. Selewski, Josephine M. Ambruzs, Gerald B. Appel, Andrew S. Bomback, Raed Bou Matar , et al. · 2018

11 year old with proximal tubule subnuclear vacuoles Open

Justin E. Juskewitch, Carl H. Cramer, Mariam P. Alexander · 2017

Negative Staining for COL4A5 Correlates With Worse Prognosis and More Severe Ultrastructural Alterations in Males With Alport Syndrome Open

Samar M. Said, Mary E. Fidler, Anthony M. Valeri, Brooke McCann, Wade Fiedler , et al. · 2016

Thus, the COL4A5 expression pattern has an important prognostic value and it correlates with the severity of ultrastructural glomerular basement membrane alterations in males with AS. Loss of COL4A5 staining is uncommon in patients with AS…

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