Carl R. Flannery
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Author Swipe
View article: Ketamine treatment in youth for fast reduction of suicidality and engagement in psychotherapy: An ongoing randomized placebo controlled trial
Ketamine treatment in youth for fast reduction of suicidality and engagement in psychotherapy: An ongoing randomized placebo controlled trial Open
View article: Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs
Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs Open
Introduction: Post-traumatic osteoarthritis (PTOA) develops following traumatic articular insult. One model system used to study the progression and treatment of PTOA is the destabilization of the medial meniscus (DMM) as first described b…
View article: Composition and Bioactivity of a Placental Tissue Particulate (PTP-001) Indicate Greater Potential than Platelet-Rich Plasma for the Treatment of Osteoarthritis
Composition and Bioactivity of a Placental Tissue Particulate (PTP-001) Indicate Greater Potential than Platelet-Rich Plasma for the Treatment of Osteoarthritis Open
Objective This study was conducted to compare therapeutically relevant properties of platelet-rich plasma (PRP), a commonly used autologous intra-articular treatment for osteoarthritis (OA), with those of a novel placental tissue particula…
View article: A novel placental tissue biologic, PTP-001, inhibits inflammatory and catabolic responses in vitro and prevents pain and cartilage degeneration in a rat model of osteoarthritis
A novel placental tissue biologic, PTP-001, inhibits inflammatory and catabolic responses in vitro and prevents pain and cartilage degeneration in a rat model of osteoarthritis Open
PTP-001 represents a promising biologic treatment for osteoarthritis, with a multi-modal mechanism of action that may contribute to symptom management and disease modification.
View article: Characterization and preclinical efficacy of PTP-001, a novel human tissue biologic in development for the treatment of OA
Characterization and preclinical efficacy of PTP-001, a novel human tissue biologic in development for the treatment of OA Open
View article: Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrate Novel Roles for MMP-13 and ADAMTS-4 in C-Terminal Processing of SLRPs
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrate Novel Roles for MMP-13 and ADAMTS-4 in C-Terminal Processing of SLRPs Open
Cartilage regeneration requires a balance of anabolic and catabolic processes. This study examined the susceptibility of fibromodulin (FMOD) and lumican (LUM) to degradation by MMP-13, ADAMTS-4 and ADAMTS-5, the three major degradative pro…
View article: Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis
Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis Open
Treatment with NASHA is an effective and safe single-injection procedure, which can be beneficial in the clinical management of knee OA.
View article: Efficacy of a novel, locally delivered TrkA inhibitor in preclinical models of OA and joint pain
Efficacy of a novel, locally delivered TrkA inhibitor in preclinical models of OA and joint pain Open
View article: Lubricin and its potential as an OA therapy
Lubricin and its potential as an OA therapy Open