Carl Zingmark
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View article: Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients
Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients Open
View article: Prognostic genome and transcriptome signatures in colorectal cancers
Prognostic genome and transcriptome signatures in colorectal cancers Open
View article: Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy
Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy Open
View article: 570P Subclasses of microsatellite-instability colorectal cancer with unique molecular features and immune cell infiltration patterns
570P Subclasses of microsatellite-instability colorectal cancer with unique molecular features and immune cell infiltration patterns Open
View article: Prognostic whole-genome and transcriptome signatures in colorectal cancers
Prognostic whole-genome and transcriptome signatures in colorectal cancers Open
Colorectal cancer (CRC) is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways 1 . To understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole…
View article: <i>Porphyromonas gingivalis</i> in Colorectal Cancer and its Association to Patient Prognosis
<i>Porphyromonas gingivalis</i> in Colorectal Cancer and its Association to Patient Prognosis Open
Microbiota dysbiosis may affect both the development and progression of colorectal cancer (CRC). Large metagenomic studies have highlighted specific oral bacteria linked to CRC including Porphyromonas gingivalis. Few studies have ho…
View article: Tumour Colonisation of Parvimonas micra Is Associated with Decreased Survival in Colorectal Cancer Patients
Tumour Colonisation of Parvimonas micra Is Associated with Decreased Survival in Colorectal Cancer Patients Open
Increasing evidence suggests that the gut microbiota may impact colorectal cancer (CRC) development and progression. In this study, the tumour colonisation of two CRC-associated bacteria, Parvimonas micra and Fusobacterium nucleatum, was s…
View article: Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes
Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes Open
Obesity and metabolic dysfunction are implicated in colorectal cancer development. Appetite-regulating gut hormones might have a role in colorectal cancer risk. We investigated whether circulating levels of the gut hormones ghrelin (analyz…
View article: Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer
Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer Open
The importance of the tumour microbiome in different aspects of colorectal cancer (CRC) has been increasingly recognised, but many questions remain. The aim of this study was to explore the effect of specific CRC associated microbes on the…
View article: A modified protein marker panel to identify four consensus molecular subtypes in colorectal cancer using immunohistochemistry
A modified protein marker panel to identify four consensus molecular subtypes in colorectal cancer using immunohistochemistry Open
View article: A Detailed Flow Cytometric Analysis of Immune Activity Profiles in Molecular Subtypes of Colorectal Cancer
A Detailed Flow Cytometric Analysis of Immune Activity Profiles in Molecular Subtypes of Colorectal Cancer Open
The local anti-tumour immune response has important prognostic value in colorectal cancer (CRC). In the era of immunotherapy, a better understanding of the immune response in molecular subgroups of CRC may lead to significant advances in p…
View article: Parvimonas micra as a putative non-invasive faecal biomarker for colorectal cancer
Parvimonas micra as a putative non-invasive faecal biomarker for colorectal cancer Open
View article: Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells
Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells Open
Colorectal cancer (CRC) is a heterogeneous disease, with varying clinical presentations and patient prognosis. Different molecular subgroups of CRC should be treated differently and therefore, must be better characterized. Organoid culture…
View article: A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer
A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer Open
Body fatness increases the risk of colorectal cancer (CRC). Insulin resistance and altered adipokines are potential mechanisms, but previous biomarker studies have been inconsistent. Intertumoral heterogeneity might provide an explanation.…
View article: Metabolic factors and the risk of colorectal cancer by <i>KRAS</i> and <i>BRAF</i> mutation status
Metabolic factors and the risk of colorectal cancer by <i>KRAS</i> and <i>BRAF</i> mutation status Open
Factors related to energy metabolism and the metabolic syndrome, such as higher body mass index (BMI), blood glucose, or blood lipids, and blood pressure, are associated with an increased risk of colorectal cancer (CRC). However, CRC is a …
View article: MicroRNA Expression in KRAS- and BRAF-mutated Colorectal Cancers
MicroRNA Expression in KRAS- and BRAF-mutated Colorectal Cancers Open
Our results suggest that KRAS- and BRAF-mutated CRCs may have different miRNA signatures compared to CRC tumors wild-type in KRAS and BRAF. However, no difference in expression levels between KRAS- and BRAF-mutated tumors was evident for t…
View article: Francisella noatunensis subspecies noatunensis clpB deletion mutant impairs development of francisellosis in a zebrafish model
Francisella noatunensis subspecies noatunensis clpB deletion mutant impairs development of francisellosis in a zebrafish model Open
View article: Cancer‐associated fecal microbial markers in colorectal cancer detection
Cancer‐associated fecal microbial markers in colorectal cancer detection Open
Colorectal cancer (CRC) is the second most common cause of cancer death in the western world. An effective screening program leading to early detection of disease would severely reduce the mortality of CRC. Alterations in the gut microbiot…
View article: Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum
Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum Open
Francisella bacteria cause severe disease in both vertebrates and invertebrates and include one of the most infectious human pathogens. Mammalian cell lines have mainly been used to study the mechanisms by which Francisella manipulates its…