Carla Duncan
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View article: Acquisition of bedaquiline and clofazimine resistance in association with a novel loss-of-function mutation in the <i>pepQ</i> gene during treatment of multidrug-resistant tuberculosis
Acquisition of bedaquiline and clofazimine resistance in association with a novel loss-of-function mutation in the <i>pepQ</i> gene during treatment of multidrug-resistant tuberculosis Open
Background Bedaquiline (BDQ) has transformed the management of multidrug-resistant (MDR) and rifampin-resistant tuberculosis (TB). Unfortunately, the expanded use of BDQ in these regimens has been accompanied by resistance, which is steadi…
View article: Diagnostic and public health investigation of <i>Mycobacterium tuberculosis</i> infection in a dog in Ontario, Canada
Diagnostic and public health investigation of <i>Mycobacterium tuberculosis</i> infection in a dog in Ontario, Canada Open
A 4-y-old, female mixed-breed dog was presented to the Ontario Veterinary College for further evaluation of multiple pulmonary and hepatic masses, intrathoracic lymphadenitis, and recent development of a pyogranulomatous pleural effusion. …
View article: Molecular Epidemiology of <i>Mycobacterium tuberculosis</i> To Describe the Transmission Dynamics Among Inuit Residing in Iqaluit Nunavut Using Whole-Genome Sequencing
Molecular Epidemiology of <i>Mycobacterium tuberculosis</i> To Describe the Transmission Dynamics Among Inuit Residing in Iqaluit Nunavut Using Whole-Genome Sequencing Open
Background In the last decade, tuberculosis (TB) incidence among Inuit in the Canadian Arctic has been rising. Our aim was to better understand the transmission dynamics of TB in this remote region of Canada using whole-genome sequencing. …
View article: Polymorphisms of a Collagen-Like Adhesin Contributes to Legionella pneumophila Adhesion, Biofilm Formation Capacity and Clinical Prevalence
Polymorphisms of a Collagen-Like Adhesin Contributes to Legionella pneumophila Adhesion, Biofilm Formation Capacity and Clinical Prevalence Open
Legionellosis is a severe respiratory illness caused by the inhalation of aerosolized water droplets contaminated with the opportunistic pathogen Legionella pneumophila. The ability of L. pneumophila to produce biofilms has been associated…
View article: Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion
Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion Open
Tuberculosis remains one of the most difficult to control infectious diseases in the world. Many different factors contribute to the complexity of this disease. These include the ability of the host to control the infection which may direc…