Carla Pelusi
YOU?
Author Swipe
View article: The role of male hypogonadism, aging, and chronic diseases in characterizing adult and elderly men with erectile dysfunction: a cross-sectional study
The role of male hypogonadism, aging, and chronic diseases in characterizing adult and elderly men with erectile dysfunction: a cross-sectional study Open
Background Erectile function depends on a complex interaction between demographic, metabolic, vascular, hormonal, and psychological factors that trigger erectile dysfunction (ED). In the present study we carried out a cross-sectional study…
View article: New insights into the comorbid conditions of Turner syndrome: results from a long-term monocentric cohort study
New insights into the comorbid conditions of Turner syndrome: results from a long-term monocentric cohort study Open
Purpose Many questions concerning Turner syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. The primary aim of this long-term cohort study was to estimate the incidence…
View article: The Effects of the New Therapeutic Treatments for Diabetes Mellitus on the Male Reproductive Axis
The Effects of the New Therapeutic Treatments for Diabetes Mellitus on the Male Reproductive Axis Open
One of the complications of chronic hyperglycemia and insulin resistance due to type 2 diabetes mellitus (T2DM) on the hypothalamic-pituitary-gonadal axis in men, is the high prevalence of hypogonadotropic hypogonadism, which has been rece…
View article: Overall Sexual Function in Dysmetabolic Obese Men with Low TestosteroneLevels Treated with Clomiphene Citrate
Overall Sexual Function in Dysmetabolic Obese Men with Low TestosteroneLevels Treated with Clomiphene Citrate Open
Background: Sexual disorders are the most common clinical manifestations of hypogonadism. Functional hypogonadism is the most frequent form, and clomiphene citrate (CC) has been recently introduced as a possible off-label therapeutic optio…
View article: Immune-related adverse events in the treatment of non-Hodgkin lymphoma with immune checkpoint inhibitors
Immune-related adverse events in the treatment of non-Hodgkin lymphoma with immune checkpoint inhibitors Open
Immune checkpoint inhibitors (ICIs) show efficacy in the treatment of non-Hodgkin lymphomas (NHL). However, these agents are associated with a unique group of side effects called immune-related adverse events (irAEs). We conducted an obser…
View article: Steroid reference intervals in women: influence of menopause, age and metabolism
Steroid reference intervals in women: influence of menopause, age and metabolism Open
Objective To investigate the impact of age, obesity and metabolic parameters on 13 circulating steroids in reproductive and menopausal age. To define reference intervals (RIs). Design Cross-sectional. Methods Three hundred and twenty five …
View article: Body mass index rather than the phenotype impacts precocious ultrasound cardiovascular risk markers in polycystic ovary syndrome
Body mass index rather than the phenotype impacts precocious ultrasound cardiovascular risk markers in polycystic ovary syndrome Open
Objective Research into cardiovascular disease (CV) prevention has demonstrated a variety of ultrasound (US) markers predicting risk in the general population but which have been scarcely used for polycystic ovary syndrome (PCOS). Obesity …
View article: Age-related changes in human Leydig cell status
Age-related changes in human Leydig cell status Open
STUDY QUESTION What are the consequences of ageing on human Leydig cell number and hormonal function? SUMMARY ANSWER Leydig cell number significantly decreases in parallel with INSL3 expression and Sertoli cell number in aged men, yet the …
View article: Effects of acute hCG stimulation on serum INSL3 and 25‐OH vitamin D in Klinefelter syndrome
Effects of acute hCG stimulation on serum INSL3 and 25‐OH vitamin D in Klinefelter syndrome Open
Background It has recently been suggested that the hypergonadotropic hypogonadism characterizing Klinefelter syndrome (KS) might not be due to a steroidogenic dysfunction per se, but mainly to an altered testosterone (T) secretion into the…
View article: Impact of age, body weight and metabolic risk factors on steroid reference intervals in men
Impact of age, body weight and metabolic risk factors on steroid reference intervals in men Open
Objective To evaluate the independent impact of age, obesity and metabolic risk factors on 13 circulating steroid levels; to generate reference intervals for adult men. Design Cross-sectional study. Methods Three hundred and fifteen adults…
View article: Weight loss more than glycemic control may improve testosterone in obese type 2 diabetes mellitus men with hypogonadism
Weight loss more than glycemic control may improve testosterone in obese type 2 diabetes mellitus men with hypogonadism Open
Background Functional hypogonadism is a common disorder among patients with obesity and type 2 diabetes mellitus and could be managed by first treating the underlying causes. Objective The present study was undertaken to investigate the co…
View article: The Role of Diet and Weight Loss in Improving Secondary Hypogonadism in Men with Obesity with or without Type 2 Diabetes Mellitus
The Role of Diet and Weight Loss in Improving Secondary Hypogonadism in Men with Obesity with or without Type 2 Diabetes Mellitus Open
Despite growing recognition of the issue, obesity represents one of the most common public health problems, and its rates are still increasing globally. Among the number of comorbidities and complications associated with obesity, hypogonad…
View article: Effect of clomiphene citrate treatment on the Sertoli cells of dysmetabolic obese men with low testosterone levels
Effect of clomiphene citrate treatment on the Sertoli cells of dysmetabolic obese men with low testosterone levels Open
Background Clomiphene citrate (CC) has been shown to restore the hypothalamic‐pituitary‐gonadal (HPG) axis by increasing testosterone (T) levels to physiological levels in patients with dysmetabolic conditions such as obesity, metabolic sy…
View article: The Steroid Profile of Adrenal Incidentalomas: Subtyping Subjects With High Cardiovascular Risk
The Steroid Profile of Adrenal Incidentalomas: Subtyping Subjects With High Cardiovascular Risk Open
Context Steroid profiling by mass spectrometry has shown implications for diagnosis and subtyping of adrenal tumors. Objectives To investigate steroid profiles and their cardiovascular correlates in a large cohort of patients with nonsecre…
View article: Sex hormones, obesity and type 2 diabetes: is there a link?
Sex hormones, obesity and type 2 diabetes: is there a link? Open
An imbalance in sex hormones has an important impact on type 2 diabetes (T2DM) mainly through the involvement of visceral adipose tissue. Androgens have an interesting sex-dimorphic association with T2DM, since hyperandrogenism in females …
View article: Clomiphene citrate effect in obese men with low serum testosterone treated with metformin due to dysmetabolic disorders: A randomized, double-blind, placebo-controlled study
Clomiphene citrate effect in obese men with low serum testosterone treated with metformin due to dysmetabolic disorders: A randomized, double-blind, placebo-controlled study Open
EudraCT 2011-000439-10.
View article: Retinal Photoreceptor Functions Are Compromised in Patients With Resistance to Thyroid Hormone Syndrome (RTHβ)
Retinal Photoreceptor Functions Are Compromised in Patients With Resistance to Thyroid Hormone Syndrome (RTHβ) Open
We report, to our knowledge, the first in vivo evidence of functional defects of RP in RTHβ. These changes occur independently of endogenous TH levels or the prenatal exposure to high or normal maternal TH.
View article: Human chorionic gonadotropin stimulation gives evidence of differences in testicular steroidogenesis in Klinefelter syndrome, as assessed by liquid chromatography–tandem mass spectrometry
Human chorionic gonadotropin stimulation gives evidence of differences in testicular steroidogenesis in Klinefelter syndrome, as assessed by liquid chromatography–tandem mass spectrometry Open
Background Men with Klinefelter syndrome (KS) show hypergonadotropic hypogonadism, but the pathogenesis of hypotestosteronemia remains unclear. Testicular steroidogenesis in KS men was evaluated over three decades ago after human chorionic…
View article: Sex hormone and steroid precursor measurement by simple and rapid liquid chromatography-tandem mass spectrometry (Lc-Ms/Ms) method: comparison with current routine immunoassays
Sex hormone and steroid precursor measurement by simple and rapid liquid chromatography-tandem mass spectrometry (Lc-Ms/Ms) method: comparison with current routine immunoassays Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)