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View article: Long-Term Motor and Cognitive Outcome of Deep Brain Stimulation in Patients With Parkinson Disease With a <i>GBA1</i> Pathogenic Variant
Long-Term Motor and Cognitive Outcome of Deep Brain Stimulation in Patients With Parkinson Disease With a <i>GBA1</i> Pathogenic Variant Open
This study provides Class III evidence that DBS does not worsen cognitive function in patients with GBA1-associated PD.
View article: Unraveling the role of GBA1 genotype in axial signs response to subthalamic deep brain stimulation
Unraveling the role of GBA1 genotype in axial signs response to subthalamic deep brain stimulation Open
GBA1 variants represent the most common genetic risk factor for Parkinson's disease (PD) and are associated with higher risk of developing cognitive decline and axial motor impairment. While cognitive outcomes following subthalamic deep br…
View article: The Complex Pathway of Conventional Investigations before the Diagnosis of Functional Motor Disorders
The Complex Pathway of Conventional Investigations before the Diagnosis of Functional Motor Disorders Open
Background Functional motor disorder (FMD) is a diagnosis of inclusion based on the presence of positive signs on clinical examination, and only a few tests are validated as biomarkers for FMD identification. Objectives The aim of this stu…
View article: Writing the Future: Artificial Intelligence, Handwriting, and Early Biomarkers for Parkinson’s Disease Diagnosis and Monitoring
Writing the Future: Artificial Intelligence, Handwriting, and Early Biomarkers for Parkinson’s Disease Diagnosis and Monitoring Open
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that impairs motor function, including the fine motor control required for handwriting. Traditional diagnostic methods often lack sensitivity and objectivity in the early…
View article: Usefulness of 3T MR in surgical planning for deep brain stimulation surgery: a systematic literature review
Usefulness of 3T MR in surgical planning for deep brain stimulation surgery: a systematic literature review Open
Magnetic resonance imaging (MRI) allows direct visualization and targeting of the subthalamic nucleus (STN) and the globus pallidus interna (GPi) during deep brain stimulation (DBS) surgery for Parkinson’s disease (PD). Compared to standar…
View article: Concordance between imaging and clinical based STN-DBS programming improves motor outcomes of directional stimulation in Parkinson's disease
Concordance between imaging and clinical based STN-DBS programming improves motor outcomes of directional stimulation in Parkinson's disease Open
Background Advances in STN-DBS technology, among which directional stimulation, improved Parkinson's disease (PD) treatment efficacy, while increasing the clinical programming complexity. Lead localization software may aid the stimulation …
View article: Chronic adaptive versus conventional deep brain stimulation in Parkinson’s disease: a blinded randomized pilot trial
Chronic adaptive versus conventional deep brain stimulation in Parkinson’s disease: a blinded randomized pilot trial Open
Background Adaptive deep brain stimulation (aDBS) is becoming a feasible therapeutic option in patients who are candidates for DBS, and implantable devices are now commercially available. We present the results of a blinded, randomized, cr…
View article: Safety and Effectiveness of Adaptive Versus Conventional Deep Brain Stimulation in Parkinson's Disease: A Randomised, Double-Blind, Crossover Pilot Trial
Safety and Effectiveness of Adaptive Versus Conventional Deep Brain Stimulation in Parkinson's Disease: A Randomised, Double-Blind, Crossover Pilot Trial Open
View article: Risk factors and significance of post-operative edema in Parkinson Disease patients submitted to deep brain stimulation. A ten-year case series
Risk factors and significance of post-operative edema in Parkinson Disease patients submitted to deep brain stimulation. A ten-year case series Open
View article: Intraoperative microelectrode recording during asleep deep brain stimulation of subthalamic nucleus for Parkinson Disease. A case series with systematic review of the literature
Intraoperative microelectrode recording during asleep deep brain stimulation of subthalamic nucleus for Parkinson Disease. A case series with systematic review of the literature Open
View article: Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity
Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity Open
Background and purpose Post‐stroke movement disorders (PMDs) following ischemic lesions of the basal ganglia (BG) are a known entity, but data regarding their incidence are lacking. Ischemic strokes secondary to proximal middle cerebral ar…
View article: Differential profiles of serum cytokines in Parkinson's disease according to disease duration
Differential profiles of serum cytokines in Parkinson's disease according to disease duration Open
View article: Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis Open
Introduction Deep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of…
View article: Long-term safety and efficacy of frameless subthalamic deep brain stimulation in Parkinson’s disease
Long-term safety and efficacy of frameless subthalamic deep brain stimulation in Parkinson’s disease Open
View article: Intraoperative Local Field Potential Beta Power and Three-Dimensional Neuroimaging Mapping Predict Long-Term Clinical Response to Deep Brain Stimulation in Parkinson Disease: A Retrospective Study
Intraoperative Local Field Potential Beta Power and Three-Dimensional Neuroimaging Mapping Predict Long-Term Clinical Response to Deep Brain Stimulation in Parkinson Disease: A Retrospective Study Open
View article: Functional Movement Disorders during COVID-19: Psychological Distress, Affective Temperament and Emotional Dysregulation
Functional Movement Disorders during COVID-19: Psychological Distress, Affective Temperament and Emotional Dysregulation Open
Background and objective: Functional movement disorders (FMD) represent a spectrum of psychosomatic symptoms particularly sensitive to stress. The COVID-19 pandemic has increased psychological distress worldwide and may have worsened FMD. …
View article: Correction to: Beyond the CAG triplet number: exploring potential predictors of delayed age of onset in Huntington’s disease
Correction to: Beyond the CAG triplet number: exploring potential predictors of delayed age of onset in Huntington’s disease Open
View article: STN-DBS does not increase the risk of sialorrhea in patients with advanced Parkinson’s disease
STN-DBS does not increase the risk of sialorrhea in patients with advanced Parkinson’s disease Open
View article: Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome
Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome Open
Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lackin…
View article: Effect of the COVID-19 pandemic and the lockdown measures on the local stroke network
Effect of the COVID-19 pandemic and the lockdown measures on the local stroke network Open
View article: Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey Open
Background: The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnera…
View article: Subacute onset dystonia in a woman affected by Parkinson’s disease following SARS-COV-2 infection
Subacute onset dystonia in a woman affected by Parkinson’s disease following SARS-COV-2 infection Open
View article: COVID-19 Pandemic and Psychiatric Symptoms: The Impact on Parkinson's Disease in the Elderly
COVID-19 Pandemic and Psychiatric Symptoms: The Impact on Parkinson's Disease in the Elderly Open
Background: The coronavirus disease 2019 (COVID-19) pandemic represents a condition of increased vulnerability and frailty for elderly patients with Parkinson's disease (PD). Social isolation may worsen the burden of the disease and specif…
View article: Predicting Factors of Functional Outcome in Patients with Acute Ischemic Stroke Admitted to Neuro-Intensive Care Unit—A Prospective Cohort Study
Predicting Factors of Functional Outcome in Patients with Acute Ischemic Stroke Admitted to Neuro-Intensive Care Unit—A Prospective Cohort Study Open
Although thrombectomy is beneficial for most stroke patients with large vessel occlusion (LVO), it has added new issues in acute management due to intensive care support. In this prospective cohort study, we described the patients admitted…
View article: Extradural Motor Cortex Stimulation might improve episodic and working memory in patients with Parkinson’s disease
Extradural Motor Cortex Stimulation might improve episodic and working memory in patients with Parkinson’s disease Open
View article: Assessment of neurological manifestations in hospitalized patients with COVID‐19
Assessment of neurological manifestations in hospitalized patients with COVID‐19 Open
Background and purpose The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐positive patients, comparing their frequency with a po…
View article: Frameless stereotaxy in subthalamic deep brain stimulation: 3-year clinical outcome
Frameless stereotaxy in subthalamic deep brain stimulation: 3-year clinical outcome Open
Background In most centers, the surgery of deep brain stimulation (DBS) is performed using a stereotactic frame. Compared with frame-based technique, frameless stereotaxy reduces the duration of surgical procedure and patient’s discomfort,…
View article: Effect of lockdown on the management of ischemic stroke: an Italian experience from a COVID hospital
Effect of lockdown on the management of ischemic stroke: an Italian experience from a COVID hospital Open
View article: Stroke and COVID19: Not only a large-vessel disease
Stroke and COVID19: Not only a large-vessel disease Open
View article: An Italian Neurology Outpatient Clinic Facing SARS-CoV-2 Pandemic: Data From 2,167 Patients
An Italian Neurology Outpatient Clinic Facing SARS-CoV-2 Pandemic: Data From 2,167 Patients Open
Objective: Neurological sequelae of SARS-CoV-2 infection have already been reported, but there is insufficient data about the impact of the pandemic on the management of the patients with chronic neurological diseases. We aim to ana…