Carla S. Coffin
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View article: Early maternal tenofovir treatment and infant vaccination: a scalable model for hepatitis B virus mother-to-child transmission control in resource-limited areas
Early maternal tenofovir treatment and infant vaccination: a scalable model for hepatitis B virus mother-to-child transmission control in resource-limited areas Open
View article: Chronic hepatitis B virus persistence: Mechanisms, consequences and implications for achieving cure
Chronic hepatitis B virus persistence: Mechanisms, consequences and implications for achieving cure Open
HBV persists within the hepatocyte due to the presence of intranuclear covalently closed circular DNA (cccDNA) and double-stranded linear DNA (dslDNA) integration. These bodies pose formidable challenges for achieving HBV functional and st…
View article: Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant‐Free Survival
Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant‐Free Survival Open
Background & Aims Only 25% of hepatitis B‐related acute liver failure (HBV‐ALF) patients survive without liver transplantation (transplant‐free survival, TFS). There is limited study of immunological and virological profiles in these patie…
View article: A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis
A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis Open
Guanine-rich nucleic acids can form a unique secondary structure called Guanine-quadruplexes (G4s). These G4s are conserved across all domains of life and in viruses, where they can play important regulatory roles in the viral lifecycle. I…
View article: La prise en charge de l'hépatite B chronique: mise à jour 2025 des lignes directrices de l'Association canadienne pour l'étude du foie et de l'Association pour la microbiologie médicale et l'infectiologie Canada
La prise en charge de l'hépatite B chronique: mise à jour 2025 des lignes directrices de l'Association canadienne pour l'étude du foie et de l'Association pour la microbiologie médicale et l'infectiologie Canada Open
L'infection chronique par le virus de l'hépatite B (VHB) pose d'importants problèmes de santé publique au Canada, en particulier chez les nouveaux arrivants provenant de régions à forte prévalence du VHB. Conformément à l'objectif de l'Org…
View article: The management of chronic hepatitis B: 2025 Guidelines update from the Canadian Association for the Study of the Liver and Association of Medical Microbiology and Infectious Disease Canada
The management of chronic hepatitis B: 2025 Guidelines update from the Canadian Association for the Study of the Liver and Association of Medical Microbiology and Infectious Disease Canada Open
Chronic hepatitis B virus (HBV) infection poses significant public health challenges in Canada, particularly among newcomers from regions with high HBV prevalence. In alignment with the World Health Organization’s goal of HBV elimination b…
View article: Development of Low-Cost In-House Assays for Quantitative Detection of HBsAg, HBeAg, and HBV DNA to Enhance Hepatitis B Virus Diagnostics and Antiviral Screening in Resource-Limited Settings
Development of Low-Cost In-House Assays for Quantitative Detection of HBsAg, HBeAg, and HBV DNA to Enhance Hepatitis B Virus Diagnostics and Antiviral Screening in Resource-Limited Settings Open
Globally, an estimated 254 million people are living with chronic hepatitis B virus (HBV) infection, yet only 10.5% have been diagnosed, underscoring the urgent need to expand testing to meet the World Health Organization’s HBV elimination…
View article: Investing in the future: training for clinical care and research in liver disease
Investing in the future: training for clinical care and research in liver disease Open
View article: Investir dans l'avenir : Formation pour les soins cliniques et la recherche sur les maladies du foie
Investir dans l'avenir : Formation pour les soins cliniques et la recherche sur les maladies du foie Open
View article: Dedicated Automatic Recall Hepatocellular Cancer Surveillance Programme Demonstrates High Retention: A Population‐Based Cohort Study
Dedicated Automatic Recall Hepatocellular Cancer Surveillance Programme Demonstrates High Retention: A Population‐Based Cohort Study Open
Introduction Patient, clinician, and system‐related barriers may affect adherence to hepatocellular carcinoma (HCC) surveillance programmes. The impact of a dedicated automated recall HCC surveillance programme on retention rates in patien…
View article: Number of people treated for hepatitis C virus infection in 2014-2023 and applicable lessons for new HBV and HDV therapies
Number of people treated for hepatitis C virus infection in 2014-2023 and applicable lessons for new HBV and HDV therapies Open
Long-term hepatitis C virus (HCV) infection can lead to cirrhosis and liver cancer. Since 2014, these infections can be effectively treated with 8-12 weeks of oral therapies. In 2015, the World Health Organization established targets to el…
View article: P-2360. Wastewater-Based Surveillance of Hepatitis A Virus Across Communities in Alberta, Canada
P-2360. Wastewater-Based Surveillance of Hepatitis A Virus Across Communities in Alberta, Canada Open
Background Hepatitis A virus (HAV) incident infection in Canada is rarely diagnosed (i.e. incidence of 3.6-10 cases/100,000 persons) (PMID: 18159360). Infections generally relate to imported contaminated food-products, or travelers returni…
View article: Variation in Nucleos(t)ide Analogue Use in Medicare Part D Throughout the United States
Variation in Nucleos(t)ide Analogue Use in Medicare Part D Throughout the United States Open
View article: Epidemiology and natural history of chronic Hepatitis B in the Canadian province of Alberta from 2012 to 2021: A population-based study
Epidemiology and natural history of chronic Hepatitis B in the Canadian province of Alberta from 2012 to 2021: A population-based study Open
CHB incidence decreased in Alberta, which is consistent with nationwide trends. Males and individuals aged 45-64 had higher CHB incidence and prevalence. CHB patients' lower survival rates emphasize the need to address barriers to guidelin…
View article: Hépatite aiguë chez un jeune de 18 ans au retour d’un voyage
Hépatite aiguë chez un jeune de 18 ans au retour d’un voyage Open
View article: Sequential Peg-IFN after bepirovirsen may reduce post-treatment relapse in chronic hepatitis B
Sequential Peg-IFN after bepirovirsen may reduce post-treatment relapse in chronic hepatitis B Open
View article: Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure
Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure Open
Hepatitis B Virus (HBV) infection carries a significant health burden worldwide. It is a leading cause of acute and chronic liver disease resulting in cirrhosis and hepatocellular carcinoma (HCC). This virus affects millions globally, and …
View article: Canadian Association for the Study of the Liver Single Topic Conference on Hepatitis B Virus: ‘Progress toward hepatitis B elimination in Canada’
Canadian Association for the Study of the Liver Single Topic Conference on Hepatitis B Virus: ‘Progress toward hepatitis B elimination in Canada’ Open
Hepatitis B virus (HBV) infection affects >290 million people worldwide, including ∼250,000 Canadians, and it stands as a leading cause of end-stage liver disease and liver cancer. The World Health Assembly has set goals for HBV eliminatio…
View article: Epidemiology, Treatment Patterns and Survival in Canadian Patients With Chronic Hepatitis B‐Related Hepatocellular Carcinoma
Epidemiology, Treatment Patterns and Survival in Canadian Patients With Chronic Hepatitis B‐Related Hepatocellular Carcinoma Open
Chronic hepatitis B (CHB) is the leading cause of hepatocellular carcinoma (HCC) globally. We described and evaluated the outcomes of patients with CHB‐HCC in Canada. In this retrospective cross‐sectional cohort study, data were analysed f…
View article: Assessment of HBV variants and novel viral and immune biomarkers in chronic hepatitis B patients with metabolic dysfunction associated steatotic liver disease
Assessment of HBV variants and novel viral and immune biomarkers in chronic hepatitis B patients with metabolic dysfunction associated steatotic liver disease Open
Co‐existing chronic hepatitis B virus (CHB) infection and metabolic dysfunction associated steatotic liver disease (MASLD) can exert complex effects on hepatic metabolism, requiring mechanistic study. CHB participants were assessed for MAS…
View article: Spending on nucleos(t)ide analogues for hepatitis B in medicaid beneficiaries: 2012-2021
Spending on nucleos(t)ide analogues for hepatitis B in medicaid beneficiaries: 2012-2021 Open
Increased generic use has significantly reduced expenditures for NA drugs; policy shifts towards generic drug use may help with sustainability.
View article: Acute hepatitis in an 18-year-old returning traveller
Acute hepatitis in an 18-year-old returning traveller Open
KEY POINTS An 18-year-old man, born in Pakistan, presented to the emergency department with a 4-day history of fever (self-reported 38.5°C), chills, abdominal pain, anorexia, and 2 days of emesis. He was previously healthy and had returned…
View article: Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection
Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection Open
NCT03615066 be found at https://www.gileadclinicaltrials.com/transparency-policy/.
View article: Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories
Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories Open
View article: Hepatitis B Virus Genotype Influence on Virological and Enzymatic Measures over Time—A Retrospective Longitudinal Cohort Study
Hepatitis B Virus Genotype Influence on Virological and Enzymatic Measures over Time—A Retrospective Longitudinal Cohort Study Open
HBV is a hepatotropic virus with multiple genotypes. It is uncertain if specific genotype(s) influence virological measures and/or liver markers over time. It is unclear whether nucleos(t)ide analogue therapy response is influenced by geno…
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Contents Open
View article: Systemic cytokine and viral antigen-specific responses in hepatitis D virus RNA positive versus HDV RNA negative patients
Systemic cytokine and viral antigen-specific responses in hepatitis D virus RNA positive versus HDV RNA negative patients Open
Background Hepatitis B virus (HBV)/Hepatitis D Virus (HDV) co-infection increases the risk of severe liver disease compared to HBV mono-infection. Adaptive immune responses to HDV are weakly detectable, and the involvement of innate immuni…
View article: Diagnosis of esophageal varices by liver stiffness and serum biomarkers in virus-related compensated advanced chronic liver disease
Diagnosis of esophageal varices by liver stiffness and serum biomarkers in virus-related compensated advanced chronic liver disease Open
Background: Individuals infected with hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency (HIV) viruses can experience compensated advanced chronic liver disease (cACLD) leading to esophageal varices (EV). In patients at low r…
View article: Hepatitis B virus serum RNA transcript isoform composition and proportion in chronic hepatitis B patients by nanopore long-read sequencing
Hepatitis B virus serum RNA transcript isoform composition and proportion in chronic hepatitis B patients by nanopore long-read sequencing Open
Introduction Serum hepatitis B virus (HBV) RNA is a promising new biomarker to manage and predict clinical outcomes of chronic hepatitis B (CHB) infection. However, the HBV serum transcriptome within encapsidated particles, which is the bi…
View article: Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries
Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries Open