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View article: Unraveling the impact of prenatal air pollution for neonatal brain maturation
Unraveling the impact of prenatal air pollution for neonatal brain maturation Open
View article: Arnaldo Milián Castro University Clinical and Surgical Hospital Comprehensive Healthcare Model for Pediatric Patients Screened in the Retinopathy of Prematurity Program
Arnaldo Milián Castro University Clinical and Surgical Hospital Comprehensive Healthcare Model for Pediatric Patients Screened in the Retinopathy of Prematurity Program Open
View article: Associations of <sup>18</sup>F-RO-948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum
Associations of <sup>18</sup>F-RO-948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum Open
INTRODUCTION We investigated the presence of neurofibrillary tangles (NFT) and their association with amyloid plaques and fluid biomarkers of Alzheimer’s disease (AD) in cognitively unimpaired individuals (CU). METHODS Ninety-nine CU indiv…
View article: Recursive KalmanNet: Deep Learning-Augmented Kalman Filtering for State Estimation with Consistent Uncertainty Quantification
Recursive KalmanNet: Deep Learning-Augmented Kalman Filtering for State Estimation with Consistent Uncertainty Quantification Open
State estimation in stochastic dynamical systems with noisy measurements is a challenge. While the Kalman filter is optimal for linear systems with independent Gaussian white noise, real-world conditions often deviate from these assumption…
View article: Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers Open
Magnetic resonance Imaging (MRI)-derived brain-age prediction is a promising biomarker of biological brain aging. Accelerated brain aging has been found in Alzheimer's disease (AD) and other neurodegenerative diseases. However, no previous…
View article: Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p‐tau in the earliest Alzheimer's <i>continuum</i>: Evidence across two independent cohorts
Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p‐tau in the earliest Alzheimer's <i>continuum</i>: Evidence across two independent cohorts Open
INTRODUCTION Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. We assessed longitudinal brain atrophy and …
View article: Unraveling the Impact of Prenatal Air Pollution on Neonatal Brain Maturation
Unraveling the Impact of Prenatal Air Pollution on Neonatal Brain Maturation Open
View article: Impact of Prenatal Exposure to Airborne Particulate Matter on Local Functional Connections in the Cerebral Cortex of Neonates
Impact of Prenatal Exposure to Airborne Particulate Matter on Local Functional Connections in the Cerebral Cortex of Neonates Open
View article: The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer’s disease
The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer’s disease Open
CSF concentrations of β-amyloid 42 (Aβ42) and phosphorylated tau (p-tau) are well-established biomarkers of Alzheimer’s disease and have been studied in relation to several neuropathological features both in patients and in cognitively uni…
View article: Associations of <sup>18</sup>F‐RO‐948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum
Associations of <sup>18</sup>F‐RO‐948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum Open
Background Fluid biomarkers provide a convenient way to predict AD pathophysiology. However, few studies have focused on determining associations with tau neurofibrillary tangle pathology in the early preclinical AD continuum, relevant to …
View article: Unmasking early cerebral blood flow alterations with time‐encoded ASL in Alzheimer's continuum
Unmasking early cerebral blood flow alterations with time‐encoded ASL in Alzheimer's continuum Open
Background Arterial spin labelling (ASL) is a non‐invasive MRI technique for quantifying cerebral blood flow (CBF), used for monitoring changes over the course of a disease or treatment. A crucial parameter in ASL is the post‐labelling del…
View article: Associations of 18F‐RO‐948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum
Associations of 18F‐RO‐948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum Open
Background Fluid biomarkers provide a convenient way to predict AD pathophysiology. However, few studies have focused on determining associations with tau neurofibrillary tangle pathology in the early preclinical AD continuum, relevant to …
View article: Sex/gender effects of glial reactivity on preclinical Alzheimer’s disease pathology
Sex/gender effects of glial reactivity on preclinical Alzheimer’s disease pathology Open
View article: Functional structure of local connections and differentiation of cerebral cortex areas in the neonate
Functional structure of local connections and differentiation of cerebral cortex areas in the neonate Open
View article: Structural Brain Differences in the Alzheimer’s Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium
Structural Brain Differences in the Alzheimer’s Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium Open
Diversity in data offers unique insights into the neural substrate of AD; however, harmonized processing and transparency of data collection are needed. Global collaborations should embrace the inherent heterogeneity that exists in the dat…
View article: Issue Information
Issue Information Open
OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open access by providing
View article: The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study
The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study Open
View article: Effect of neuroinflammation markers on the relation between A, T and N: sex‐specific resilience or vulnerability?
Effect of neuroinflammation markers on the relation between A, T and N: sex‐specific resilience or vulnerability? Open
Background Sex‐specific vulnerability and resilience along the amyloid cascade may be partly explained by neuroinflammatory processes. Microglial activation may play a more important role in the development of Alzheimer’s disease (AD) in w…
View article: Analysis of blood and cerebrospinal fluid flows in preclinical AD. Preliminary results from ALFA+ cohort
Analysis of blood and cerebrospinal fluid flows in preclinical AD. Preliminary results from ALFA+ cohort Open
Background Intracranial cerebrospinal fluid (CSF) motion is driven by the wave pressure associated with arterial blood flow into the skull (Figure 1). Since one of the roles of CSF is the clearance of neural waste, it was investigated the …
View article: Association of human brain‐age with genetically predicted plasma levels of brain rejuvenating and aging factors identified in mice
Association of human brain‐age with genetically predicted plasma levels of brain rejuvenating and aging factors identified in mice Open
Background Aging is the primary risk factor for Alzheimer’s disease. Experiments in mice have identified circulating proteins with an “aging/rejuvenating” effect on the brain. However, whether these proteins have an effect on the human bra…
View article: Exploring biomarker profiles of the cognitively unimpaired individuals in early tau PET Braak stage
Exploring biomarker profiles of the cognitively unimpaired individuals in early tau PET Braak stage Open
Background In this study, we evaluated the association between tau PET and fluid biomarkers and explored biological mechanisms associated with elevated tau in cognitively unimpaired(CU) individuals. Method Seventy‐nine CU individuals from …
View article: Cognitively Unimpaired Multiparous Women Have Higher CSF p‐tau181 Levels Which Have More Deleterious Effects on Neurodegeneration and Executive Function
Cognitively Unimpaired Multiparous Women Have Higher CSF p‐tau181 Levels Which Have More Deleterious Effects on Neurodegeneration and Executive Function Open
Background Epidemiologic studies show that multiparity (≥3 children) is associated with a higher risk of clincal AD in cognitively unimpaired (CU) women. However, studies exploring the impact of parity on AD biomarkers are scarce. We explo…
View article: Brain‐age mediates the association between modifiable risk factors and cognitive decline early in the AD continuum
Brain‐age mediates the association between modifiable risk factors and cognitive decline early in the AD continuum Open
Background Neuroimaging‐derived brain‐age is a useful biomarker to study the brain’s biological aging process. Brain‐age has shown cross‐sectional associations with cognitive function and modifiable risk factors for dementia. We aimed to s…
View article: Exploring biomarker profiles of the cognitively unimpaired individuals in early tau PET Braak stage
Exploring biomarker profiles of the cognitively unimpaired individuals in early tau PET Braak stage Open
Background In this study, we evaluated the association between tau PET and fluid biomarkers and explored biological mechanisms associated with elevated tau in cognitively unimpaired(CU) individuals. Method Seventy‐nine CU individuals from …
View article: CSF sTREM2 and YKL‐40 modify the balance between soluble and fibrillary β‐amyloid in non‐demented individuals
CSF sTREM2 and YKL‐40 modify the balance between soluble and fibrillary β‐amyloid in non‐demented individuals Open
Background Cerebrospinal fluid (CSF) Aβ concentrations and Positron Emission Tomography (PET) imaging provide information of two different Aβ pools. Identifying the factors affecting the balance between soluble and deposited Aβ may inform …
View article: Brain‐age mediates the association between modifiable risk factors and cognitive decline early in the AD continuum
Brain‐age mediates the association between modifiable risk factors and cognitive decline early in the AD continuum Open
Background Neuroimaging‐derived brain‐age is a useful biomarker to study the brain’s biological aging process. Brain‐age has shown cross‐sectional associations with cognitive function and modifiable risk factors for dementia. We aimed to s…
View article: Metabolic changes in preclinical AD as detected by magnetic resonance spectroscopy
Metabolic changes in preclinical AD as detected by magnetic resonance spectroscopy Open
Background Biochemical changes, which may precede morphological changes, could be of great relevance in profiling preclinical AD. We aimed to investigate metabolic changes using magnetic resonance spectroscopy (MRS) in three AD‐relevant re…
View article: Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer’s disease
Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer’s disease Open
Background The biological mechanisms underlying structural brain changes in early Alzheimer’s disease (AD) are not well understood. Combining a wide selection of biomarkers of AD pathology, synaptic dysfunction, neuroaxonal injury, and neu…
View article: CSF Aβ42/40 is associated with neurodegeneration independently of CSF p‐tau in the earliest AD <i>continuum</i>
CSF Aβ42/40 is associated with neurodegeneration independently of CSF p‐tau in the earliest AD <i>continuum</i> Open
Background Soluble Aβ dyshomeostasis is thought to be the earliest detectable alteration in AD, but is believed to have little impact on neurodegeneration. Conversely, the onset of tau pathology in the presence of Aβ drives subsequent neur…
View article: Genetic predisposition to Alzheimer’s disease is differentially associated with joint volumetric variations in the disease continuum
Genetic predisposition to Alzheimer’s disease is differentially associated with joint volumetric variations in the disease continuum Open
Background Imaging genetics studies commonly assess the individual association between genetic information and brain features without considering joint brain modulations. The aim of this study was to explore the structural variation of the…