Carlie Sigel
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View article: Hepatocellular Carcinoma Growth Kinetics and Outcomes After Transarterial Embolization: A Single-Center Analysis
Hepatocellular Carcinoma Growth Kinetics and Outcomes After Transarterial Embolization: A Single-Center Analysis Open
Purpose: This study examines the association between tumor volume doubling time (TVDT) and clinical outcomes for patients with hepatocellular carcinoma (HCC) treated with transarterial embolization (TAE) and evaluates the impact of tumor g…
View article: Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras
Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras Open
SUMMARY KRAS is among the most frequently mutated oncogenes in cancer. Yet, mutations in KRAS are common only in tumors originating from a subset of tissues. It is critical to understand the molecular mechanisms underlying this oncogene ti…
View article: Histologic- and Genomic-Directed Adjuvant Therapy for Ampullary Adenocarcinoma: A Hidden Genome–Derived Analysis
Histologic- and Genomic-Directed Adjuvant Therapy for Ampullary Adenocarcinoma: A Hidden Genome–Derived Analysis Open
Background: The benefit of adjuvant chemotherapy (AC) for ampullary adenocarcinoma is unclear. The Hidden Genome model classifies prognostic subtypes with greater accuracy than standard histologic classification (intestinal [INT] vs pancre…
View article: TP53 Mutation Predicts Worse Survival and Earlier Local Progression in Patients with Hepatocellular Carcinoma Treated with Transarterial Embolization
TP53 Mutation Predicts Worse Survival and Earlier Local Progression in Patients with Hepatocellular Carcinoma Treated with Transarterial Embolization Open
The aim of this study was to evaluate associations between TP53 status and outcomes after transarterial embolization (TAE) for the treatment of patients with hepatocellular carcinoma (HCC). This single-institution study included patients f…
View article: Engineered extrachromosomal oncogene amplifications promote tumorigenesis
Engineered extrachromosomal oncogene amplifications promote tumorigenesis Open
View article: Supplementary Figure S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Figure S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Supplementary Figure S1 One-versus-rest precision-recall area under the curve (AUC) of each class and the overall accuracy of the three-class model (A) and the two-class model (B). EHC: extrahepatic cholangiocarcinoma; GBC: gallbladder can…
View article: Supplementary Table S8 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S8 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Histologic subtypes of biliary-class and HCC-class intrahepatic cholangiocarcinoma (IHC).
View article: Supplementary Table S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Genes (n = 341) common to all MSK-IMPACT panels.
View article: Data from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Data from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Purpose:Intrahepatic cholangiocarcinoma (IHC) is a heterogeneous tumor. The hidden-genome classifier, a supervised machine learning–based algorithm, was used to quantify tumor heterogeneity and improve classification.Experimental Design:A …
View article: Supplementary Figure S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Figure S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Supplementary Figure S3 Overall survival stratified by biliary class in non-resected patients (A) and resected patients (B) without IDH1 mutations or FGFR2 fusion. Interaction between the presence of any IDH1 or FGFR2 mutation and the geno…
View article: Supplementary Table S7 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S7 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Incidence of IDH1 mutations and FGF2 fusions in biliary-aligned intrahepatic cholangiocarcinoma (IHC) and hepatocellular carcinoma (HCC)-aligned IHC.
View article: Supplementary Table S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Genes (n = 341) common to all MSK-IMPACT panels.
View article: Supplementary Table S6 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S6 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Incidence of the key genetic alterations observed in intrahepatic cholangiocarcinoma classified based on the biliary score.
View article: Supplementary Table S5 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S5 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Comparison of clinicopathologic characteristics of IHC genomic subclasses.
View article: Supplementary Table S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Prevalence of genes altered in 10% or more cases.
View article: Supplementary Figure S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Figure S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Supplementary Figure S2 The genomic alterations in extrahepatic biliary tumors and hepatocellular carcinoma are visualized using two-dimensional embeddings of the lasso-selected active genetic predictors in the training data, which include…
View article: Supplementary Table S8 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S8 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Histologic subtypes of biliary-class and HCC-class intrahepatic cholangiocarcinoma (IHC).
View article: Supplementary Table S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Prevalence of genes altered in 10% or more cases.
View article: Supplementary Table S6 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S6 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Incidence of the key genetic alterations observed in intrahepatic cholangiocarcinoma classified based on the biliary score.
View article: Supplementary Figure S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Figure S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Supplementary Figure S1 One-versus-rest precision-recall area under the curve (AUC) of each class and the overall accuracy of the three-class model (A) and the two-class model (B). EHC: extrahepatic cholangiocarcinoma; GBC: gallbladder can…
View article: Supplementary Table S4 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S4 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
This table reports the lasso-selected active genetic predictors of the hidden-genome model. The predictive power is represented by the GBC/EHC odds ratio (OR) or HCC OR. The max OR is the greater of the two values. The Shannon-Jensen impor…
View article: Supplementary Table S7 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S7 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Incidence of IDH1 mutations and FGF2 fusions in biliary-aligned intrahepatic cholangiocarcinoma (IHC) and hepatocellular carcinoma (HCC)-aligned IHC.
View article: Supplementary Table S5 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S5 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Comparison of clinicopathologic characteristics of IHC genomic subclasses.
View article: Supplementary Table S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Genetic pathway alterations.
View article: Data from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Data from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Purpose:Intrahepatic cholangiocarcinoma (IHC) is a heterogeneous tumor. The hidden-genome classifier, a supervised machine learning–based algorithm, was used to quantify tumor heterogeneity and improve classification.Experimental Design:A …
View article: Supplementary Table S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Genetic pathway alterations.
View article: Supplementary Table S4 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Table S4 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
This table reports the lasso-selected active genetic predictors of the hidden-genome model. The predictive power is represented by the GBC/EHC odds ratio (OR) or HCC OR. The max OR is the greater of the two values. The Shannon-Jensen impor…
View article: Supplementary Figure S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Figure S2 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Supplementary Figure S2 The genomic alterations in extrahepatic biliary tumors and hepatocellular carcinoma are visualized using two-dimensional embeddings of the lasso-selected active genetic predictors in the training data, which include…
View article: Supplementary Figure S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Supplementary Figure S3 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier Open
Supplementary Figure S3 Overall survival stratified by biliary class in non-resected patients (A) and resected patients (B) without IDH1 mutations or FGFR2 fusion. Interaction between the presence of any IDH1 or FGFR2 mutation and the geno…
View article: Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer Open