Carlo Alfieri
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View article: Calciphylaxis Diagnosis, Management and Future Directions: a Comprehensive Update on behalf of the European Renal Association CKD-MBD Working Group
Calciphylaxis Diagnosis, Management and Future Directions: a Comprehensive Update on behalf of the European Renal Association CKD-MBD Working Group Open
Calciphylaxis, or calcific uraemic arteriolopathy, is a rare and life-threatening condition predominantly affecting people receiving dialysis. Characterised by painful necrotic skin lesions due to arteriolar calcification and thrombosis, c…
View article: Association of incident dialysis modality with patient survival: a systematic review and meta-analysis
Association of incident dialysis modality with patient survival: a systematic review and meta-analysis Open
Background Although the choice of dialysis technique is based on several factors, patient survival is undoubtedly one of the most relevant. In a context where randomization to either peritoneal dialysis (PD) or hemodialysis (HD) proved to …
View article: Incremental peritoneal dialysis: less is more—for the patient and the planet
Incremental peritoneal dialysis: less is more—for the patient and the planet Open
Climate change poses growing threat to global health, and paradoxically, the health-care sector—including nephrology—is a significant contributor to greenhouse gas (GHG) emissions. Dialysis, in particular, is resource-intensive. Yet, dialy…
View article: MicroRNA signatures of cancer risk in kidney transplant patients: insights from the COMETA study
MicroRNA signatures of cancer risk in kidney transplant patients: insights from the COMETA study Open
View article: #2425 Prevalence and correlates of hepatic steatosis and fibrosis in chronic kidney disease patients prior of kidney transplantation: a retrospective cohort study
#2425 Prevalence and correlates of hepatic steatosis and fibrosis in chronic kidney disease patients prior of kidney transplantation: a retrospective cohort study Open
Background and Aims Metabolic dysfunction associated steatotic liver disease (MASLD), is closely linked to CKD and increases the risk of hepatic fibrosis and cardiovascular damage. MASLD is common in the general population but data on dial…
View article: Early Onset <i>Mycoplasma</i> spp. Infection After Kidney Transplantation: A Systematic Review
Early Onset <i>Mycoplasma</i> spp. Infection After Kidney Transplantation: A Systematic Review Open
Background In recent years, there has been a progressive increase in the number of Mycoplasma spp. infections (MIs) reported among kidney transplant (KT) recipients. Although in these patients MIs have been associated with life‐threatening…
View article: Simultaneous removal and replacement of the peritoneal catheter in PD patients with partial refractory peritonitis
Simultaneous removal and replacement of the peritoneal catheter in PD patients with partial refractory peritonitis Open
In patients on peritoneal dialysis (PD) peritonitis continues to be the main cause of PD-related death, and the leading reason of transfer to hemodialysis (HD). International guidelines recommend that peritoneal catheter should be removed …
View article: Caloric restriction protects from acute and chronic kidney injury by inhibiting monocyte recruitment
Caloric restriction protects from acute and chronic kidney injury by inhibiting monocyte recruitment Open
Diet influences disease progression, yet the effects of fasting on acute kidney injury (AKI) and its transition to chronic kidney disease (CKD) remain unclear. This study evaluated fasting-mimicking diet (FMD) cycles versus ad libitum
View article: Association of Incident Dialysis Modality With Patient Survival: A Systematic Review and Meta-analysis
Association of Incident Dialysis Modality With Patient Survival: A Systematic Review and Meta-analysis Open
Background Although the choice of dialysis technique is based on several factors, patient survival is undoubtedly one of the most relevant. In a context where randomization to either peritoneal dialysis (PD) or hemodialysis (HD) proved to …
View article: Impact of immunosuppressive therapy on pulmonary perfusion in kidney transplant recipients after COVID-19 illness
Impact of immunosuppressive therapy on pulmonary perfusion in kidney transplant recipients after COVID-19 illness Open
Introduction Patients who have received kidney transplants (KTR) are considered to be more susceptible to the severity of COVID-19-related illness. The transplanted patient’s respiratory outcome worsened because of the ventilation-perfusio…
View article: Novel evidence on the management of HCV-associated glomerular disease
Novel evidence on the management of HCV-associated glomerular disease Open
View article: Exit-site relocation by external splicing: A rescue therapy for damaged tunneled central venous catheter
Exit-site relocation by external splicing: A rescue therapy for damaged tunneled central venous catheter Open
Effective hemodialysis (HD) depends on efficient, durable, and safe vascular access. Despite incessant efforts to reduce the use of tunneled central venous catheter (tCVC), late referrals, poor planning, improper creation of arteriovenous …
View article: A new chapter for GCND, the Giornale di Clinica Nefrologica e Dialisi
A new chapter for GCND, the Giornale di Clinica Nefrologica e Dialisi Open
View article: Osteosarcopenia in Chronic Kidney Disease: An Overlooked Syndrome?
Osteosarcopenia in Chronic Kidney Disease: An Overlooked Syndrome? Open
Background Healthy ageing relies on maintaining physiological systems, particularly the musculoskeletal system (MKS). After 50, declines in bone density, muscle mass and strength increase the risk of osteoporosis and sarcopenia, leading to…
View article: Tenecteplase versus alteplase in patients with acute ischemic stroke: An updated meta-analysis of randomized controlled trials
Tenecteplase versus alteplase in patients with acute ischemic stroke: An updated meta-analysis of randomized controlled trials Open
In patients with acute ischemic stroke, TNK demonstrated a significant advantage over alteplase in achieving excellent functional outcomes. The incidence of early neurological improvement, symptomatic intracranial hemorrhage, all-cause dea…
View article: Neurofibromatosis type I (NF1) and bone involvement in a pediatric setting: insights from FGF23 levels
Neurofibromatosis type I (NF1) and bone involvement in a pediatric setting: insights from FGF23 levels Open
View article: World Kidney Day: a call to action for chronic kidney disease prevention and multidisciplinary care
World Kidney Day: a call to action for chronic kidney disease prevention and multidisciplinary care Open
Chronic Kidney Disease (CKD) has emerged as a major global public health challenge, affecting approximately 10% of the population worldwide. Often asymptomatic in its early stages, CKD frequently goes undiagnosed until significant renal im…
View article: Neurofibromatosis Type I (NF1) and Bone Involvement in a pediatric setting: Insights from FGF23 Levels
Neurofibromatosis Type I (NF1) and Bone Involvement in a pediatric setting: Insights from FGF23 Levels Open
Background Neurofibromatosis type I (NF1) is an autosomal dominant disorder characterized by extremely different phenotypes, sometimes including reduced bone mass. The underlying cause of bone impairment in these patients remains poorly un…
View article: Post-Kidney Transplant Cancer: A Real-World Retrospective Analysis From a Single Italian Center
Post-Kidney Transplant Cancer: A Real-World Retrospective Analysis From a Single Italian Center Open
We describe the epidemiology of cancer after kidney transplantation (KTx), investigating its risk factors and impact on therapeutic management and survival in KTx recipients (KTRs). The association between modification of immunosuppressive…
View article: What Not to Overlook in the Management of Patients with Type 2 Diabetes Mellitus: The Nephrological and Hepatological Perspectives
What Not to Overlook in the Management of Patients with Type 2 Diabetes Mellitus: The Nephrological and Hepatological Perspectives Open
Diabetes mellitus (DM) significantly impacts renal and hepatic function, necessitating comprehensive understanding and management strategies. Renal involvement, namely diabetic kidney disease (DKD), presents a global challenge, with increa…
View article: Brain-Derived Neurotrophic Factor-Loaded Low-Temperature-Sensitive liposomes as a drug delivery system for repairing podocyte damage
Brain-Derived Neurotrophic Factor-Loaded Low-Temperature-Sensitive liposomes as a drug delivery system for repairing podocyte damage Open
View article: Kidney transplantation in patients with ANCA-associated vasculitis is associated with a high incidence of post-transplant cancer
Kidney transplantation in patients with ANCA-associated vasculitis is associated with a high incidence of post-transplant cancer Open
View article: PMMA dialyzers modulate both humoral and cell-mediate immune response to anti-COVID-19 vaccine (BNT162b2) in a cohort of chronic hemodialyzed patients
PMMA dialyzers modulate both humoral and cell-mediate immune response to anti-COVID-19 vaccine (BNT162b2) in a cohort of chronic hemodialyzed patients Open
View article: Targeted silencing of GNAS in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program
Targeted silencing of GNAS in a human model of osteoprogenitor cells results in the deregulation of the osteogenic differentiation program Open
Introduction The dysregulation of cell fate toward osteoprecursor cells associated with most GNAS -based disorders may lead to episodic de novo extraskeletal or ectopic bone formation in subcutaneous tissues. The bony lesion distribution s…
View article: Post-Transplant Diabetes Mellitus in Kidney-Transplanted Patients: Related Factors and Impact on Long-Term Outcome
Post-Transplant Diabetes Mellitus in Kidney-Transplanted Patients: Related Factors and Impact on Long-Term Outcome Open
This study aimed to investigate the prevalence and determinants of glucose metabolism abnormalities and their impact on long-term clinical outcomes in kidney transplant recipients (KTxps). A retrospective analysis of 832 KTxps (2004–2020) …
View article: Peritoneal dialysis related peritonitis: insights from a long-term analysis of an Italian center
Peritoneal dialysis related peritonitis: insights from a long-term analysis of an Italian center Open
View article: #1214 Post-kidney transplant cancer: incidence, risk factors and future perspectives. Real-world analysis of a single Italian center
#1214 Post-kidney transplant cancer: incidence, risk factors and future perspectives. Real-world analysis of a single Italian center Open
Background Our retrospective observational study aims to describe the epidemiology of cancer after KTx and to investigate its risk factors and the impact on therapeutic management and survival, in a big monocentric cohort of kidney transpl…
View article: #1219 Extracellular vesicles from patients with AMR-induced reprogramming of human podocytes into senescent cells: role of SGLT2i
#1219 Extracellular vesicles from patients with AMR-induced reprogramming of human podocytes into senescent cells: role of SGLT2i Open
Background and Aims Extracellular vesicles (EVs) are organelles released by different cells that deliver biological information into the extracellular space and contribute to several diseases. However, their role in patients with antibody-…
View article: #2895 Erythropoietin Resistance Index (ERI) between mortality and metabolic changes in a cohort of hemodialysis patients. What acts below the surface?
#2895 Erythropoietin Resistance Index (ERI) between mortality and metabolic changes in a cohort of hemodialysis patients. What acts below the surface? Open
Background and Aims The management of anemia in hemodialysis patients (HD-ps) is influenced by many factors, including inflammation, martial balance (MB) and mineral metabolism (MM). Recent data would identify the Erythropoietin Resistance…
View article: #1207 Post transplant diabetes mellitus in kidney transplanted patients: factors related and impact on long-term outcome
#1207 Post transplant diabetes mellitus in kidney transplanted patients: factors related and impact on long-term outcome Open
Background Alterations in glucose metabolism are one of the most important complications of renal transplant recipients. The aim of this study was to analyze their prevalence and determinants and assess their influence on the main long-ter…