Carlo Marcucci
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View article: Efficacy and Safety of Desmopressin in Terms of Bleeding and Transfusion in Cardiac Surgery With Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis
Efficacy and Safety of Desmopressin in Terms of Bleeding and Transfusion in Cardiac Surgery With Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis Open
Bleeding and transfusion during cardiac surgery are major sources of complications. Surgery and cardiopulmonary bypass can induce coagulopathy, including platelet dysfunction. Desmopressin has been shown to reduce bleeding and transfusion …
View article: PPARγ Expression in Human Spermatozoa and Its Relationship with Seminal F2-Isoprostanes and Resolvin D1 in the Presence of Varicocele and Urogenital Infections
PPARγ Expression in Human Spermatozoa and Its Relationship with Seminal F2-Isoprostanes and Resolvin D1 in the Presence of Varicocele and Urogenital Infections Open
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a regulating agent in antioxidant response also involved in controlling inflammation. The impact of varicocele and urogenital infections on sperm PPARγ expression was studied. The…
View article: Intraoperative Dexmedetomidine Use for Enhanced Recovery after Surgery (ERAS) in Cardiac Surgery—Single Center Retrospective Observational Cohort Study
Intraoperative Dexmedetomidine Use for Enhanced Recovery after Surgery (ERAS) in Cardiac Surgery—Single Center Retrospective Observational Cohort Study Open
Background and Objectives: Dexmedetomidine, an alpha-2 agonist, is used as an adjunct to anesthesia in enhanced recovery after surgery (ERAS) programs. One of its advantages is the opioid-sparing effect which can facilitate early extubatio…
View article: A study of ChatGPT in facilitating Heart Team decisions on severe aortic stenosis
A study of ChatGPT in facilitating Heart Team decisions on severe aortic stenosis Open
The use of LLMs offers promising opportunities to improve the HT decision-making process. This study showed that ChatGPT's decisions were consistent with those of the HT in a large proportion of cases. This technology could serve as a fail…
View article: Post-transplant survival with pre-transplant durable continuous-flow mechanical circulatory support in a Swiss cohort of heart transplant recipients
Post-transplant survival with pre-transplant durable continuous-flow mechanical circulatory support in a Swiss cohort of heart transplant recipients Open
BACKGROUND: Worldwide, almost half of all heart transplantation candidates arrive today at their transplant operation with durable continuous-flow mechanical circulatory support (CF-MCS). This evolution is due to a progressive increase of …
View article: Identification of High Platelet Reactivity Despite ADP P2Y12 Inhibitor Treatment: Two Populations in the Vasodilator-Stimulated Phosphoprotein Assay and Variable PFA-P2Y Shapes of Curve
Identification of High Platelet Reactivity Despite ADP P2Y12 Inhibitor Treatment: Two Populations in the Vasodilator-Stimulated Phosphoprotein Assay and Variable PFA-P2Y Shapes of Curve Open
Introduction Response to ADP P2Y12 receptor inhibition by clopidogrel can be evaluated by various techniques. Here, we compared a functional rapid point-of-care technique (PFA-P2Y) with the degree of biochemical inhibition assessed by the …
View article: How to Solve the Conundrum of Heparin-Induced Thrombocytopenia during Cardiopulmonary Bypass
How to Solve the Conundrum of Heparin-Induced Thrombocytopenia during Cardiopulmonary Bypass Open
Heparin-induced thrombocytopenia (HIT) is a major issue in cardiac surgery requiring cardiopulmonary bypass (CPB). HIT represents a severe adverse drug reaction after heparin administration. It consists of immune-mediated thrombocytopenia …
View article: Vasoplegic Syndrome after Cardiopulmonary Bypass in Cardiovascular Surgery: Pathophysiology and Management in Critical Care
Vasoplegic Syndrome after Cardiopulmonary Bypass in Cardiovascular Surgery: Pathophysiology and Management in Critical Care Open
Vasoplegic syndrome (VS) is a common complication following cardiovascular surgery with cardiopulmonary bypass (CPB), and its incidence varies from 5 to 44%. It is defined as a distributive form of shock due to a significant drop in vascul…
View article: Has the profile of heart transplantation recipients changed within the last three decades?
Has the profile of heart transplantation recipients changed within the last three decades? Open
BACKGROUND: Heart transplantation remains the most durable treatment for patients with end-stage heart failure refractory to medical treatment. Central elements of the listing criteria for heart transplantation have remained largely unchan…
View article: Challenges in Patient Blood Management for Cardiac Surgery: A Narrative Review
Challenges in Patient Blood Management for Cardiac Surgery: A Narrative Review Open
About 15 years ago, Patient Blood Management (PBM) emerged as a new paradigm in perioperative medicine and rapidly found support of all major medical societies and government bodies. Blood products are precious, scarce and expensive and th…
View article: Impact of an enhanced recovery after surgery pathway on thoracoscopic lobectomy outcomes in non-small cell lung cancer patients: a propensity score-matched study
Impact of an enhanced recovery after surgery pathway on thoracoscopic lobectomy outcomes in non-small cell lung cancer patients: a propensity score-matched study Open
Adoption of an ERAS pathway for VATS lobectomies in NSCLC patients has decreased the length of hospital stay and the cardiopulmonary complication rate without affecting the readmission rate.
View article: Massive Hemorrhage: The Role of Whole Blood Viscoelastic Assays
Massive Hemorrhage: The Role of Whole Blood Viscoelastic Assays Open
Viscoelastic whole blood tests are increasingly used to guide hemostatic therapy in bleeding patients in the perioperative, trauma, and obstetric settings. Compared with standard laboratory tests of hemostasis, they have a shorter turnarou…
View article: Transapical approach versus transcervical approach for transcatheter aortic valve replacement: a retrospective monocentric study
Transapical approach versus transcervical approach for transcatheter aortic valve replacement: a retrospective monocentric study Open
OBJECTIVES Transfemoral approach is the standard access-route for transcatheter aortic valve replacement (TAVR). However, alternative approaches are needed in a number of patients and accesses such as transapical (TA) TAVR or transcervical…
View article: Tricuspid valve Swan‐Ganz catheter entrapment before cardiac surgery
Tricuspid valve Swan‐Ganz catheter entrapment before cardiac surgery Open
Summary A Swan‐Ganz catheter during cardiac surgery offers peri‐operative haemodynamic monitoring, although insertion of these catheters is not without risk. We report a case of Swan‐Ganz catheter entrapment within the tricuspid valve duri…
View article: Short-term single-centre experience with the HeartMate 3 left ventricular assist device for advanced heart failure
Short-term single-centre experience with the HeartMate 3 left ventricular assist device for advanced heart failure Open
OBJECTIVES The objective of this study was to analyse clinical characteristics, survival and adverse events of patients with advanced heart failure supported using the Abbott HeartMate 3 left ventricular assist device (LVAD). METHODS We re…
View article: Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial
Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial Open
ClinicalTrials.gov NCT02775123 . Registered 17 May 2016.
View article: Clinical results of continuous flow ventricular assist devices: A comparative analysis between heartmate 3 and heart ware. Are centrifugal pumps all the same?
Clinical results of continuous flow ventricular assist devices: A comparative analysis between heartmate 3 and heart ware. Are centrifugal pumps all the same? Open
Background: Compare clinical outcomes of the last generation centrifugal LVADs implanted as bridge to transplant.Methods: Retrospective analysis of demographics, clinical parameters, surgical technique, adverse events and survival in patie…
View article: Additional file 1: of Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial
Additional file 1: of Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial Open
Table S1. Baseline and peri-operative characteristics of patients included in the coagulation sub study. *There were no significant differences between the groups with regard to any pre-operative or intra-operative characteristics (all p v…
View article: An enhanced recovery after surgery program for video-assisted thoracoscopic surgery anatomical lung resections is cost-effective
An enhanced recovery after surgery program for video-assisted thoracoscopic surgery anatomical lung resections is cost-effective Open
An ERAS program for VATS anatomical lung resection is cost-effective and is associated with a lower complication rate and a shorter postoperative hospitalization.
View article: Experimental ex vivo lung perfusion with sevoflurane: effects on damaged donor lung grafts
Experimental ex vivo lung perfusion with sevoflurane: effects on damaged donor lung grafts Open
These findings suggest that the potential of sevoflurane in protecting the lungs donated after cardiac death and reconditioned using EVLP could improve the outcome of these lungs following subsequent transplantation.
View article: P4280Contemporary predictors of contrast-induced acute kidney injury
P4280Contemporary predictors of contrast-induced acute kidney injury Open
PCI -Procedure complications 87571.1% Gy•cm 2 (CI 95% 30.2%-90.1%) in PCI procedures.The ratio EFD / Fluoroscopy time was highly significantly reduced in group A (39.9±22 vs 54.3±22, p<0.0001).Subgroup analysis showed that radiation differ…
View article: Recommendations for the perioperative management of patients with cardiac implantable electronic device
Recommendations for the perioperative management of patients with cardiac implantable electronic device Open
This joint position paper gives a concise overview of the pre-, intra- and postoperative issues and management of pacemaker and defibrillator carriers in the setting of electrocautery used for surgery.