Carlo Sacdalan
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View article: HIV serologic reactivity varies with time of ART initiation in persons on long-term ART
HIV serologic reactivity varies with time of ART initiation in persons on long-term ART Open
HIV serologic responses measured by clinical screening assays may be blunted when antiretroviral treatment (ART) suppresses HIV replication from the initial infection stages, with further decay following long-term treatment. Sensitivity ma…
View article: Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity
Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity Open
The HIV-1 envelope glycoprotein (Env) is expressed at the surface of infected cells and, as such, can be targeted by non-neutralizing antibodies (nnAbs) that mediate antibody-dependent cellular cytotoxicity (ADCC). Previous single-molecule…
View article: Primed B cells continue to undergo affinity maturation in people living with HIV-1 when ART is provided in acute infection 4109
Primed B cells continue to undergo affinity maturation in people living with HIV-1 when ART is provided in acute infection 4109 Open
Description Protective, high affinity antibodies develop via mutagenesis and an iterative selection process in germinal centers called affinity maturation. For highly variable pathogens such as HIV-1, understanding the kinetics of antibody…
View article: Improved HIV-1 RNA detection using whole blood versus plasma in antiretroviral-treated individuals
Improved HIV-1 RNA detection using whole blood versus plasma in antiretroviral-treated individuals Open
Currently, nucleic acid testing (NAT) platforms detect HIV-1 in plasma. Using whole blood (WB) could improve HIV-1 detectability as cellular elements may also contain HIV-1 nucleic acids. We used well-characterized paired WB/plasma panels …
View article: Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts
Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts Open
Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive ant…
View article: The natural history of anal high-grade squamous intraepithelial lesions among MSM and transgender women in an acute HIV cohort in Thailand
The natural history of anal high-grade squamous intraepithelial lesions among MSM and transgender women in an acute HIV cohort in Thailand Open
Objective: To describe the incidence and clearance rates of anal high-grade squamous intraepithelial lesions (HSIL) among MSM and transgender women who initiated immediate antiretroviral therapy during acute HIV acquisition. Design: A pros…
View article: Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand
Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand Open
HCV coinfection is common in this group of high-risk PWH, highlighting the need for regular screening, early diagnosis, and treatment. The study participants exhibited a modest improvement in the CD4 + /CD8 + T-cell ratio and cognitive per…
View article: Activation of CXCR3 <sup>+</sup> Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development
Activation of CXCR3 <sup>+</sup> Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development Open
Lymph node T follicular helper (Tfh) cells and germinal center (GC) B cells are critical to generate potent antibodies but are rarely possible to study in humans. To understand how Tfh/GC B-cell interactions during acute HIV-1 infection (A…
View article: Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making
Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making Open
Persistent eGFRcre decrease to < 90 ml/min/1.73 m2 after switch to DTG was common in this Thai population. eGFRcystC was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART mo…
View article: Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts
Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts Open
Elimination of latent HIV-1 is a major goal of AIDS research but the host factors determining the size of these reservoirs are poorly understood. Here, we investigated whether differences in host gene expression modulate the size of the HI…
View article: Prevalence and incidence of anal high‐grade squamous intraepithelial lesions in a cohort of cisgender men and transgender women who have sex with men diagnosed and treated during acute HIV acquisition in Bangkok, Thailand
Prevalence and incidence of anal high‐grade squamous intraepithelial lesions in a cohort of cisgender men and transgender women who have sex with men diagnosed and treated during acute HIV acquisition in Bangkok, Thailand Open
Introduction Men who have sex with men (MSM), especially those living with HIV, are at an increased risk of anal cancer. The prevalence and incidence of its precursor, anal high‐grade squamous intraepithelial lesions (HSILs), among MSM who…
View article: Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand
Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand Open
Background Hepatitis C virus (HCV) coinfection may further compromise immunological and cognitive function in people with HIV (PWH). This study compared laboratory and neuropsychiatric measures across the periods of HCV seroconversion and …
View article: Framingham risk score based vascular outcomes in acute versus chronic <scp>HIV</scp> cohorts after 6 years of <scp>ART</scp>
Framingham risk score based vascular outcomes in acute versus chronic <span>HIV</span> cohorts after 6 years of <span>ART</span> Open
Introduction Immune dysregulation persists in people with HIV (PWH) on antiretroviral therapy (ART) and may lead to accelerated vascular ageing and cardiovascular disease (CVD). While delayed time to initiation of ART has been linked to wo…
View article: Cerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection
Cerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection Open
Objective: HIV-1 invades the brain within days post-transmission. This study quantitated cerebrospinal fluid (CSF) white blood cell count (WBC) and investigated whether it associated with plasma and CSF HIV-1 RNA during untreated acute HIV…
View article: CD4dimCD8bright T cells are inversely associated with neuro-inflammatory markers among people with HIV
CD4dimCD8bright T cells are inversely associated with neuro-inflammatory markers among people with HIV Open
Objective: HIV-associated neuroinflammation persists in the brain despite suppressive combination antiretroviral therapy (cART). We evaluated associations between a subset of CD8 + T cells, termed CD4 dim CD8 bright T cells, and soluble ma…
View article: Initial productive and latent HIV infections originate in vivo by infection of resting T cells
Initial productive and latent HIV infections originate in vivo by infection of resting T cells Open
Productively infected cells are generally thought to arise from HIV infection of activated CD4+ T cells, and these infected activated cells are thought to be a recurring source of latently infected cells when a portion of the population tr…
View article: Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo
Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo Open
Host restriction factors play key roles in innate antiviral defense, but it remains poorly understood which of them restricts HIV-1 in vivo. Here, we used single-cell transcriptomic analysis to identify host factors associated with HIV-1 c…
View article: Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition
Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition Open
Transgender women (TGW) are disproportionally affected by HIV infection, with a global estimated prevalence of 19.9%, often attributed to behavioral risk factors, with less known about biological factors. We evaluated potential biological …
View article: The Essential Need for Trust When Transmission Risk Cannot Be Eliminated in HIV‐Remission Trials
The Essential Need for Trust When Transmission Risk Cannot Be Eliminated in HIV‐Remission Trials Open
Analytic treatment interruption (ATI) is scientifically necessary in HIV‐remission (“cure”) studies to test the effects of new interventions. However, stopping antiretroviral treatment poses risks to research participants and their sexual …
View article: ALVAC-HIV and AIDSVAX B/E vaccination induce improved immune responses compared with AIDSVAX B/E vaccination alone
ALVAC-HIV and AIDSVAX B/E vaccination induce improved immune responses compared with AIDSVAX B/E vaccination alone Open
The RV144 phase III vaccine trial demonstrated that ALVAC-HIV and AIDSVAX B/E administration over 6 months resulted in 31% efficacy in preventing HIV acquisition, while administration of AIDSVAX B/E alone in both VAX003 and VAX004 studies …