Carlo Selmi
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View article: Multimodal immune profiling of peripheral blood to predict the response to intra-articular autologous blood-derived orthobiologic treatment in patients with knee osteoarthritis
Multimodal immune profiling of peripheral blood to predict the response to intra-articular autologous blood-derived orthobiologic treatment in patients with knee osteoarthritis Open
View article: Detection and Clinical Associations of Autoantibodies to Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A2/B1 in Patients with Systemic Sclerosis
Detection and Clinical Associations of Autoantibodies to Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A2/B1 in Patients with Systemic Sclerosis Open
Autoantibodies targeting heterogeneous nuclear ribonucleoproteins (hnRNPs) have been seldom described in autoimmune diseases but remain poorly characterized in systemic sclerosis (SSc). This study aims to investigate the prevalence and cli…
View article: Correlation between serum ANCA and cancer: a decade-long retrospective analysis of an Italian cohort
Correlation between serum ANCA and cancer: a decade-long retrospective analysis of an Italian cohort Open
Background Serum antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies primarily linked with ANCA-associated vasculitides (AAV) but associated diseases include also other autoimmune diseases, infections, and malignancies. However…
View article: The Impact of Sex on the Pattern and Clinical Response of Early Psoriatic Arthritis: Real-life Data from the Italian Prospective SIRENA Study
The Impact of Sex on the Pattern and Clinical Response of Early Psoriatic Arthritis: Real-life Data from the Italian Prospective SIRENA Study Open
View article: First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry
First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry Open
Introduction Primary heart involvement (pHI) is an overlooked and poorly characterised complication of systemic sclerosis (SSc), associated with the risk of heart failure, arrhythmia and death. Despite consensus definition by the World Scl…
View article: Guselkumab and Il-17 Inhibitors Improve Patient-Perceived Impact of Psoriatic Arthritis Similarly: 6 Month Interim Results of the PsABIOnd Observational Cohort Study
Guselkumab and Il-17 Inhibitors Improve Patient-Perceived Impact of Psoriatic Arthritis Similarly: 6 Month Interim Results of the PsABIOnd Observational Cohort Study Open
Objectives Targeted drugs in PsA have demonstrated efficacy in randomized controlled trials, including aspects of patient-reported impact. However, comparison data from observational studies are scarce, particularly for IL-23 and IL-17 inh…
View article: 29-mRNA host response signatures for classification of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial
29-mRNA host response signatures for classification of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial Open
View article: Ultrasound features of fetal toxoplasmosis : diagnostic and prognostic contributions in prenatal management
Ultrasound features of fetal toxoplasmosis : diagnostic and prognostic contributions in prenatal management Open
Background: Congenital toxoplasmosis (CT) is a parasitic infection that can cause severe fetal damage, particularly when maternal infection occurs early in pregnancy. Although biological methods remain the cornerstone of prenatal diagnosis…
View article: nowledge and behavior of Tunisian men regarding the couple’s contraception. Clinical trial
nowledge and behavior of Tunisian men regarding the couple’s contraception. Clinical trial Open
Objective: To assess the knowledge and the circumstances and sources from which men in Tunisia gain knowledge about contraception and their subsequent perceptions of different contraceptive methods. Methods: A cross-sectional study conduct…
View article: Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study
Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study Open
Objectives This study assessed how changes in lung function, skin fibrosis and digital ulceration (DU) burden predict mortality in patients with SSc-associated interstitial lung disease (SSc-ILD), the leading cause of death in SSc. Methods…
View article: OP0083 The 1-year progression of systemic sclerosis-associated interstitial lung disease is predicted applying artificial intelligence tools but not visual quantification of pulmonary CT scans
OP0083 The 1-year progression of systemic sclerosis-associated interstitial lung disease is predicted applying artificial intelligence tools but not visual quantification of pulmonary CT scans Open
View article: OP0094 Biological Sex-Related Differences in Radiographic Progression and Relationship with Early Clinical Response: Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Biologic-Naive Participants with Active Psoriatic Arthritis Treated with Guselkumab
OP0094 Biological Sex-Related Differences in Radiographic Progression and Relationship with Early Clinical Response: Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Biologic-Naive Participants with Active Psoriatic Arthritis Treated with Guselkumab Open
View article: ABS1069 SEX-RELATED DIFFERENCES IN BASELINE PATIENT AND DISEASE CHARACTERISTICS: POST HOC ANALYSES OF THREE PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS
ABS1069 SEX-RELATED DIFFERENCES IN BASELINE PATIENT AND DISEASE CHARACTERISTICS: POST HOC ANALYSES OF THREE PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS Open
View article: Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance
Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance Open
The immune response to SARS-CoV-2 has been implicated in the onset of multiple, seemingly unrelated, autoimmune diseases. The immune response to SARS-CoV-2 has also been implicated in the unmasking and/or production of multiple autoantibod…
View article: Cancer in connective tissue disease
Cancer in connective tissue disease Open
The association between cancer and autoimmunity is well-recognized, as represented by the increased incidence of cancer among patients with systemic autoimmune diseases; however, the underlying mechanisms remain only partially understood. …
View article: Association of Type of Joint Involvement With Distinct Clinical Features and Outcomes in Patients With Acute Parvovirus B19-Related Arthritis
Association of Type of Joint Involvement With Distinct Clinical Features and Outcomes in Patients With Acute Parvovirus B19-Related Arthritis Open
View article: Interleukin-6 signalling: what rheumatologists should know and expect
Interleukin-6 signalling: what rheumatologists should know and expect Open
View article: E090 Guselkumab and IL-17 inhibitors improve patient-perceived impact of psoriatic arthritis similarly: 6-month interim results of the PsABIOnd observational cohort study
E090 Guselkumab and IL-17 inhibitors improve patient-perceived impact of psoriatic arthritis similarly: 6-month interim results of the PsABIOnd observational cohort study Open
Background/Aims PsA leads to significant patient-perceived burden of disease. Targeted drugs have demonstrated efficacy in randomised controlled trials including patient-reported impact. However, comparison data from observational studies …
View article: The effect of hydroxychloroquine on activities of daily living and hand function in systemic sclerosis: results from an analysis of the EUSTAR cohort
The effect of hydroxychloroquine on activities of daily living and hand function in systemic sclerosis: results from an analysis of the EUSTAR cohort Open
View article: The Impact of Menopause on Autoimmune and Rheumatic Diseases
The Impact of Menopause on Autoimmune and Rheumatic Diseases Open
View article: EQTL analyses are a formidable tool to define the immunogenetic mechanisms underpinning Spondyloarthropathies
EQTL analyses are a formidable tool to define the immunogenetic mechanisms underpinning Spondyloarthropathies Open
View article: Application of EULAR/ACR Classification Criteria for Polymyalgia Rheumatica in a Series of Patients With Acute Parvovirus B19 Infection
Application of EULAR/ACR Classification Criteria for Polymyalgia Rheumatica in a Series of Patients With Acute Parvovirus B19 Infection Open
View article: Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender
Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender Open
High disease activity, baseline erosions and disease duration are significantly associated with the D2T phenotype of RA while we confirm the importance of obesity and fibromyalgia.
View article: Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis
Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis Open
Background The phosphodiesterase 4 (PDE4) inhibitor apremilast downregulates the production of IL-23 and other pro-inflammatory cytokines involved in the pathogenesis of psoriatic arthritis (PsA). Aim To investigate the effects of apremila…
View article: Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity
Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity Open
Our results demonstrate that miR203a is just one paradigmatic TLR7-activating miRNA among the hundreds released by UV-irradiated keratinocytes, which altogether trigger pDC activation in psoriatic conditions. This represents the first evid…
View article: Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis
Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis Open
View article: Are seronegative patients with rheumatoid arthritis and clinically suspect arthralgia properly represented in randomized clinical trials?
Are seronegative patients with rheumatoid arthritis and clinically suspect arthralgia properly represented in randomized clinical trials? Open
View article: Multi-domain effectiveness of guselkumab evaluated via composite indices through 1 year in patients with PsA and inadequate response to TNFi: <i>post hoc</i> analysis of COSMOS
Multi-domain effectiveness of guselkumab evaluated via composite indices through 1 year in patients with PsA and inadequate response to TNFi: <i>post hoc</i> analysis of COSMOS Open
Objective Evaluate guselkumab efficacy, an anti-interleukin-23p19-subunit antibody, in patients with active psoriatic arthritis (PsA) and inadequate response to 1 or 2 tumour necrosis factor inhibitors (TNFi-IR), utilizing composite indice…
View article: Four-year effectiveness, safety and drug retention rate of secukinumab in psoriatic arthritis: a real-life Italian multicenter cohort
Four-year effectiveness, safety and drug retention rate of secukinumab in psoriatic arthritis: a real-life Italian multicenter cohort Open
View article: Add‐on rituximab for primary heart involvement associated with systemic sclerosis: A step forward in the tailored treatment of myocarditis?
Add‐on rituximab for primary heart involvement associated with systemic sclerosis: A step forward in the tailored treatment of myocarditis? Open