Explanipedia

Nematicide Chalcones Act Synergistically on Caenorhabditis elegans and Meloidogyne incognita Without Disrupting Soil Microbial Diversity and with Limited Toxicity to Human Cells Open

Alejandro Calderón‐Urrea, Shantanu D. Shinde, Sosse Kendoyan, Vukasin M. Jovanovic, Seungmi Ryu , et al. · 2025

Plant Parasitic Nematodes (PPNs), such as Meloidogyne incognita, cause significant agricultural losses worldwide. Conventional nematicides like methyl bromide are being phased out due to environmental and health concerns, prompting the sea…

Lysosomal free sialic acid storage disorder iPSC-derived neural cells display altered glycosphingolipid metabolism Open

Marya S. Sabir, Vukasin M. Jovanovic, Seungmi Ryu, Chaitali Sen, Pinar Ormanoglu , et al. · 2025

Promoting the adoption of best practices and standards to enhance quality and reproducibility of stem cell research Open

Lucia Selfa Aspiroz, Milena Mennecozzi, Laura Batlle‐Morera, Barbara Corneo, Lyn Healy , et al. · 2025

Highly efficient generation of self-renewing trophoblast from human pluripotent stem cells Open

Jaroslav Slamecka, Seungmi Ryu, Carlos A. Tristan, Pei‐Hsuan Chu, Claire Weber , et al. · 2024

Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons Open

Chelsey Jenna LeBlang, Maria F. Pazyra‐Murphy, Elizabeth S. Silagi, Srestha Dasgupta, Marianna Tsolias , et al. · 2024

Sensory neurons generated from induced pluripotent stem cells (iSNs) are used to model human peripheral neuropathies, however current differentiation protocols produce sensory neurons with an embryonic phenotype. Peripheral glial cells con…

hPSC-Derived Astrocytes at the Forefront of Translational Applications in Neurological Disorders Open

Vukasin M. Jovanovic, Kendall T. Mesch, Carlos A. Tristan · 2024

Astrocytes, the most abundant glial cell type in the brain, play crucial roles in maintaining homeostasis within the central nervous system (CNS). Impairment or abnormalities of typical astrocyte functions in the CNS serve as a causative o…

A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Open

Vukasin M. Jovanovic, Claire Weber, Jaroslav Slamecka, Seungmi Ryu, Pei‐Hsuan Chu , et al. · 2023

Scalable generation of sensory neurons from human pluripotent stem cells Open

Tao Deng, Vukasin M. Jovanovic, Carlos A. Tristan, Claire Weber, Pei‐Hsuan Chu , et al. · 2023

SEQUIN is an R/Shiny framework for rapid and reproducible analysis of RNA-seq data Open

Claire Weber, Marissa B. Hirst, Ben Ernest, Nicholas J. Schaub, Kelli M. Wilson , et al. · 2023

Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail Open

Carlos A. Tristan, Hyenjong Hong, Yogita Jethmalani, Yu Chen, Claire Weber , et al. · 2022

A Comprehensive Roadmap of Human Placental Development <i>in vitro</i> Open

Jaroslav Slamecka, Carlos A. Tristan, Seungmi Ryu, Pei‐Hsuan Chu, Claire Weber , et al. · 2022

Human pluripotent stem cells (hPSCs) represent a powerful model system to study early developmental processes. However, lineage specification into trophectoderm (TE) remains poorly understood and access to well-characterized placental cell…

Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells Open

Tao Deng, Carlos A. Tristan, Claire Weber, Pei‐Hsuan Chu, Seungmi Ryu , et al. · 2022

Development of new non-addictive analgesics requires advanced strategies to differentiate human pluripotent stem cells (hPSCs) into relevant cell types amenable for translational research. Here, we developed a highly efficient and reproduc…

Enhancing the Fitness of Embryoid Bodies and Organoids by Chemical Cytoprotection Open

Seungmi Ryu, Claire Weber, Pei‐Hsuan Chu, Carlos A. Tristan, Ben Ernest , et al. · 2022

Embryoid bodies (EBs) and self-organizing organoids derived from human pluripotent stem cells (hPSCs) recapitulate tissue development in a dish and hold great promise for disease modeling and drug development. However, current protocols ar…

SEQUIN: rapid and reproducible analysis of RNA-seq data in R/Shiny Open

Claire Weber, Marissa B. Hirst, Ben Ernest, Hannah M. Baskir, Carlos A. Tristan , et al. · 2022

SEQUIN is a new web application (app) that allows fast and intuitive RNA-sequencing data analysis for organisms, tissues, and single cells. Integrated app functions enable uploading datasets, quality control, gene set enrichment, data visu…

SEQUIN: Rapid and Reproducible Analysis of RNA-Seq Data in R/Shiny Open

Claire Weber, Marissa B. Hirst, Ben Ernest, Hannah M. Baskir, Pei‐Hsuan Chu , et al. · 2022

Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells Open

Carlos A. Tristan, Pinar Ormanoglu, Jaroslav Slamecka, Claire Malley, Pei‐Hsuan Chu , et al. · 2021

Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell manufacturing strategies for optimal self-renewal and functional differentiation. Traditional manual cell culture is variable and labor intensive…

A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells Open

Yu Chen, Carlos A. Tristan, Lu Chen, Vukasin M. Jovanovic, Claire Malley , et al. · 2021

Bioprinted 3D Outer Retina Barrier Uncovers RPE-dependent Choroidal Phenotype in Advanced Macular Degeneration Open

Kapil Bharti, Min Jae Song, Russell Quinn, Eric Nguyen, Tea Soon Park , et al. · 2021

Age-related macular degeneration (AMD), a leading cause of blindness, initiates in the outer-blood-retina-barrier (oBRB) formed by Retinal pigment epithelium (RPE), Bruch’s membrane, and choriocapillaris. The mechanism of AMD initiation an…

Correction to: Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules Open

Seungmi Ryu, Pei‐Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu , et al. · 2021

Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules Open

Seungmi Ryu, Pei‐Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu , et al. · 2021

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells Open

Carlos A. Tristan, Pinar Ormanoglu, Jaroslav Slamecka, Claire Malley, Pei‐Hsuan Chu , et al. · 2020

Efficient translation of human induced pluripotent stem cells (hiPSCs) depends on implementing scalable cell manufacturing strategies that ensure optimal self-renewal and functional differentiation. Currently, manual culture of hiPSCs is h…

Nuclear GAPDH cascade mediates stress-dependent pathological cardiac growth Open

Manling Zhang, Taro Kariya, Genri Numata, H. Sasaki, Masayuki Sasaki , et al. · 2019

Here we report that stress-induced nuclear translocation of GAPDH mediates heart hypertrophy via Brahma-Related-Gene-1 (BRG1)-associated chromatin remodelling. In response to pressure overload elicited by transverse aortic constriction, we…

Chemically Defined Neural Conversion of Human Pluripotent Stem Cells Open

Yu Chen, Carlos A. Tristan, Sunil K. Mallanna, Pinar Ormanoglu, Steven A. Titus , et al. · 2019

Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma Open

Diane M. Kambach, Alan Halim, A. Gesine Cauer, Qian Sun, Carlos A. Tristan , et al. · 2017

A hallmark of cellular transformation is the evasion of contact-dependent inhibition of growth. To find new therapeutic targets for glioblastoma, we looked for pathways that are inhibited by high cell density in astrocytes but not in gliom…

METB-03. DISABLED CELL DENSITY SENSING BY TUMOR SUPPRESSORS LEADS TO DYSREGULATED CHOLESTEROL SYNTHESIS IN GLIOBLASTOMA Open

Diane M. Kambach, A. Gesine Cauer, Carlos A. Tristan, Orieta Celiku, Uma Shankavaram , et al. · 2016

A hallmark of cellular transformation is the evasion of contact-dependent inhibition of growth. To find new therapeutic targets for glioblastoma, we looked for pathways that are inhibited by high cell density in normal astrocytes but have …

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