Carlos Cabañas
YOU?
Author Swipe
View article: The emerging role of human transmembrane RGD-based counter-receptors of integrins in health and disease
The emerging role of human transmembrane RGD-based counter-receptors of integrins in health and disease Open
View article: Optimizing standardized lab-grown skin substitutes evidences a proliferation-differentiation switch based on ascorbic acid
Optimizing standardized lab-grown skin substitutes evidences a proliferation-differentiation switch based on ascorbic acid Open
Developing standardized bioengineered constructs that accurately replicate human skin is a largely sought-after goal. Pathways initiated at the nurturing interface with the dermal compartment have the potential to modulate the developing e…
View article: Molecular Determinants Involved in the Docking and Uptake of Tumor-Derived Extracellular Vesicles: Implications in Cancer
Molecular Determinants Involved in the Docking and Uptake of Tumor-Derived Extracellular Vesicles: Implications in Cancer Open
Extracellular vesicles produced by tumor cells (TEVs) influence all stages of cancer development and spread, including tumorigenesis, cancer progression, and metastasis. TEVs can trigger profound phenotypic and functional changes in target…
View article: HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling Open
View article: Expression of the phagocytic receptors αMβ2 and αXβ2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells
Expression of the phagocytic receptors αMβ2 and αXβ2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells Open
Activation of the integrin phagocytic receptors CR3 (α M β 2 , CD11b/CD18) and CR4 (α X β 2 , CD11c/CD18) requires Rap1 activation and RIAM function. RIAM controls integrin activation by recruiting Talin to β 2 subunits, enabling the Talin…
View article: ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles
ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles Open
Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal metastasis, a condition associated with a very poor prognosis. In these cancers, tumor-derived extracellular vesicles (EVs) cause immunosuppression, fa…
View article: Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer Open
Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peri…
View article: Cellular Integrin α5β1 and Exosomal ADAM17 Mediate the Binding and Uptake of Exosomes Produced by Colorectal Carcinoma Cells
Cellular Integrin α5β1 and Exosomal ADAM17 Mediate the Binding and Uptake of Exosomes Produced by Colorectal Carcinoma Cells Open
Approximately 25% of colorectal cancer (CRC) patients develop peritoneal metastasis, a condition associated with a bleak prognosis. The CRC peritoneal dissemination cascade involves the shedding of cancer cells from the primary tumor, thei…
View article: Structural mechanism of laminin recognition by integrin
Structural mechanism of laminin recognition by integrin Open
View article: Tetraspanin CD9 affects HPV16 infection by modulating ADAM17 activity and the ERK signalling pathway
Tetraspanin CD9 affects HPV16 infection by modulating ADAM17 activity and the ERK signalling pathway Open
View article: RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment
RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment Open
The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles. The activation of this receptor is dependent on signals derived from other receptors (ins…
View article: Phagocytic Integrins: Activation and Signaling
Phagocytic Integrins: Activation and Signaling Open
Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. R…
View article: Editorial: Functional Relevance of Tetraspanins in the Immune System
Editorial: Functional Relevance of Tetraspanins in the Immune System Open
AS is supported by a Netherlands Organization for Scientific Research Grant (NWO) Gravitation Programme 2013 grant (ICI-024.002.009), a Dutch Cancer Society grant (KUN2014-6845), and was awarded an European Research Council Consolidator Gr…
View article: Development of a quantitative method to measure EV uptake
Development of a quantitative method to measure EV uptake Open
The outstanding potential of Extracellular Vesicles (EVs) in medicine, deserves a detailed study of the molecular aspects regulating their incorporation into target cells. However, because EV size lies below the limit of resolution of opti…
View article: Phosphatase of Regenerating Liver-1 (PRL-1) Regulates Actin Dynamics During Immunological Synapse Assembly and T Cell Effector Function
Phosphatase of Regenerating Liver-1 (PRL-1) Regulates Actin Dynamics During Immunological Synapse Assembly and T Cell Effector Function Open
The regulatory role of most dual specific phosphatases during T cell activation remains unknown. Here, we have studied the expression and function of phosphatases of regenerating liver (PRLs: PRL-1, PRL-2, and PRL-3) during T cell activati…
View article: CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17
CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17 Open
Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative count…
View article: Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression Open
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs) that function as mediators of intercellular communication by transferring biological information between cells. Tumor-derived EVs have emerged as impor…
View article: Tetraspanin CD9: A Key Regulator of Cell Adhesion in the Immune System
Tetraspanin CD9: A Key Regulator of Cell Adhesion in the Immune System Open
The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4+ T cells, CD8+ T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and…
View article: A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles
A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles Open
View article: Conformational equilibria and intrinsic affinities define integrin activation
Conformational equilibria and intrinsic affinities define integrin activation Open
View article: Relating conformation to function in integrin α <sub>5</sub> β <sub>1</sub>
Relating conformation to function in integrin α <sub>5</sub> β <sub>1</sub> Open
Significance β 1 integrins form the largest and most diverse integrin subfamily, with 12 distinct αβ heterodimers. Together, the seven other integrin β-subunits form an equal number of 12 heterodimers. Despite speculation that different in…
View article: Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid Open
In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the parenchyma and the meninges, but also in the cerebro…
View article: Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1
Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1 Open
Stimulation by chemokines of integrin α4β1–dependent T-lymphocyte adhesion is a crucial step for lymphocyte trafficking. The adaptor Vav1 is required for chemokine-activated T-cell adhesion mediated by α4β1. Conceivably, proteins associati…
View article: Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9
Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 Open