Explanipedia

Characterization of Na+currents regulating intrinsic excitability of optic tectal neurons Open

Adrian C. Thompson, Carlos D. Aizenman · 2023

Developing neurons adapt their intrinsic excitability to maintain stable output despite changing synaptic input. The mechanisms behind this process remain unclear. In this study, we examined Xenopus optic tectal neurons and found that the …

Regulation of Nav1.6-mediated sodium currents underlie the homeostatic control of neuronal intrinsic excitability in the optic tectum of the developingXenopus laevistadpole Open

Adrian C. Thompson, Carlos D. Aizenman · 2021

For individual neurons to function appropriately within a network that is undergoing synaptic reorganization and refinement due to developmental or experience-dependent changes in circuit activity, they must homeostatically adapt their int…

Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis Open

Sayali V. Gore, Eric J. James, Lin-Chien Huang, Jenn J. Park, Andrea Berghella , et al. · 2021

Matrix metalloproteinase-9 (MMP-9) is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive environments for neuronal development and plasticity. Developmental dysregulation of MMP-9 may also lead to neurode…

Author response: Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis Open

Sayali V. Gore, Eric J. James, Lin-Chien Huang, Jenn J. Park, Andrea Berghella , et al. · 2021

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Matrix metalloproteinase-9 (MMP-9) is a se…

Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes Open

Karine Liu, Alfonso Garcia, Jenn J. Park, Alexis A. Toliver, Lizmaylin Ramos , et al. · 2021

Decision letter: Microglial trogocytosis and the complement system regulate axonal pruning in vivo Open

Carlos D. Aizenman, Cornelius T. Gross, Amanda Sierra · 2020

Behavioral assays to study neural development in Xenopus laevis tadpoles Open

Arseny S. Khakhalin, Virgilio Lopez, Carlos D. Aizenman · 2020

Escape responses, orienting reflexes, and social behaviors in Xenopus laevis tadpoles have been well documented in the literature (Lee et al. 2010; Roberts et al. 2000; Simmons et al. 2004; Katz et al. 1981; Villinger and Waldman 2012). In…

Role of matrix metalloproteinase-9 in neurodevelopmental disorders and experience-dependent plasticity in Xenopus tadpoles Open

Sayali V. Gore, Eric J. James, Lin-Chien Huang, Jenn J. Park, Andrea Berghella , et al. · 2020

Matrix metalloproteinase-9 (MMP-9) is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive environments for neuronal development and plasticity. Developmental dysregulation of MMP-9 is also associated with …

Decision letter: Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance Open

Carlos D. Aizenman · 2020

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neuromodulatory systems are essential for …

Early developmental exposure to Fluoxetine and Citalopram results in different neurodevelopmental outcomes Open

Karine Liu, Alfonso Garcia, Jenn J. Park, Alexis A. Toliver, Lizmaylin Ramos , et al. · 2019

Although selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for prenatal depression, there exists controversy over the adverse effects of SSRI use on fetal development. Few studies have adequately isolated outcomes due…

Issue Information Open

Eduardo R. Macagno, Darcy B. Kelley, J. W. Fawcett, Moses V. Chao, Carlos D. Aizenman , et al. · 2019

Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…

Issue Information Open

Eduardo R. Macagno, Darcy B. Kelley, James W. Fawcett, Moses V. Chao, Carlos D. Aizenman , et al. · 2019

Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…

Decision letter: Precise excitation-inhibition balance controls gain and timing in the hippocampus Open

Carlos D. Aizenman · 2018

Decision letter: Precise excitation-inhibition balance controls gain and timing in the hippocampus Open

Carlos D. Aizenman · 2018

Issue Information Open

David A. Brafman, Karl Willert, George Smith, Gianluca Gallo, Ruxandra F. Sîrbulescu , et al. · 2017

Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…

A cellular mechanism for inverse effectiveness in multisensory integration Open

Torrey L.S. Truszkowski, Oscar A Carrillo, Julia Bleier, Carolina M Ramirez-Vizcarrondo, Daniel L Felch , et al. · 2017

To build a coherent view of the external world, an organism needs to integrate multiple types of sensory information from different sources, a process known as multisensory integration (MSI). Previously, we showed that the temporal depende…

Author response: A cellular mechanism for inverse effectiveness in multisensory integration Open

Torrey L.S. Truszkowski, Oscar A Carrillo, Julia Bleier, Carolina M Ramirez-Vizcarrondo, Daniel L Felch , et al. · 2017

Article Figures and data Abstract Introduction Results and discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract To build a coherent view of the external world, an organ…

Emergence of Selectivity to Looming Stimuli in a Spiking Network Model of the Optic Tectum Open

Eric Jang, Carolina M Ramirez-Vizcarrondo, Carlos D. Aizenman, Arseny S. Khakhalin · 2016

The neural circuits in the optic tectum of Xenopus tadpoles are selectively responsive to looming visual stimuli that resemble objects approaching the animal at a collision trajectory. This selectivity is required for adaptive collision av…

Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits Open

Torrey L.S. Truszkowski, Eric J. James, Mashfiq Hasan, Tyler J. Wishard, Zhenyu Liu , et al. · 2016

Multisensory integration in the developing tectum is constrained by the balance of excitation and inhibition Open

Daniel L Felch, Arseny S. Khakhalin, Carlos D. Aizenman · 2016

Multisensory integration (MSI) is the process that allows the brain to bind together spatiotemporally congruent inputs from different sensory modalities to produce single salient representations. While the phenomenology of MSI in vertebrat…

Author response: Multisensory integration in the developing tectum is constrained by the balance of excitation and inhibition Open

Daniel L Felch, Arseny S. Khakhalin, Carlos D. Aizenman · 2016

Correction: Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity Open

Christopher M. Ciarleglio, Arseny S. Khakhalin, Angelia F Wang, Alexander C Constantino, Sarah P Yip , et al. · 2016

A population of gap junction-coupled neurons drives recurrent network activity in a developing visual circuit Open

Zhenyu Liu, Christopher M. Ciarleglio, Ali S. Hamodi, Carlos D. Aizenman, Kara G. Pratt · 2016

In many regions of the vertebrate brain, microcircuits generate local recurrent activity that aids in the processing and encoding of incoming afferent inputs. Local recurrent activity can amplify, filter, and temporally and spatially parse…

Neurobiology: Setting the Set Point for Neural Homeostasis Open

Torrey L.S. Truszkowski, Carlos D. Aizenman · 2015

Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity Open

Christopher M. Ciarleglio, Arseny S. Khakhalin, Angelia F Wang, Alexander C Constantino, Sarah P Yip , et al. · 2015

Biophysical properties of neurons become increasingly diverse over development, but mechanisms underlying and constraining this diversity are not fully understood. Here we investigate electrophysiological characteristics of Xenopus tadpole…

Author response: Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity Open

Christopher M. Ciarleglio, Arseny S. Khakhalin, Angelia F Wang, Alexander C Constantino, Sarah P Yip , et al. · 2015

Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Biophysical pr…

Valproate-Induced Neurodevelopmental Deficits inXenopus laevisTadpoles Open

Eric J. James, Jenny Gu, Carolina M Ramirez-Vizcarrondo, Mashfiq Hasan, Torrey L.S. Truszkowski , et al. · 2015

Autism spectrum disorder (ASD) is increasingly thought to result from low-level deficits in synaptic development and neural circuit formation that cascade into more complex cognitive symptoms. However, the link between synaptic dysfunction…

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