Carlos D. Llanos
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View article: Feedback-responsive cell factories for dynamic modulation of the unfolded protein response
Feedback-responsive cell factories for dynamic modulation of the unfolded protein response Open
Engineering cell factories that support the production of large quantities of protein therapeutics remains a significant biomanufacturing challenge. The overexpression of secretory proteins causes proteotoxic stress, affecting cell viabili…
View article: Molecular characterization of carbapenemase-producing Enterobacterales in a tertiary hospital in Lima, Peru
Molecular characterization of carbapenemase-producing Enterobacterales in a tertiary hospital in Lima, Peru Open
Carbapenemase-producing Enterobacterales (CPE) are a growing threat to global health and the economy. Understanding the interactions between resistance and virulence mechanisms of CPE is crucial for managing difficult-to-treat infections a…
View article: Cell factory engineering: Challenges and opportunities for synthetic biology applications
Cell factory engineering: Challenges and opportunities for synthetic biology applications Open
The production of high‐quality recombinant proteins is critical to maintaining a continuous supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell factories presents a number of limitations typically assoc…
View article: SYNTHETIC BIOLOGY APPROACHES FOR MAMMALIAN CELL FACTORY ENGINEERING
SYNTHETIC BIOLOGY APPROACHES FOR MAMMALIAN CELL FACTORY ENGINEERING Open
The production of high-quality recombinant proteins is critical to maintaining a continuous supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell factories presents a number of limitations typically assoc…
View article: Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum β-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru
Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum β-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru Open
Urinary tract infections (UTIs) are a common human infection. Antibiotic resistance in extended-spectrum β-lactamase (ESBL)-producing uropathogenic E. coli (UPEC) is a major therapeutic challenge due to limited treatment alternatives. The …
View article: Complete Genome Sequences of Two Salmonella enterica Lytic Phages, NBSal006 and NBSal007
Complete Genome Sequences of Two Salmonella enterica Lytic Phages, NBSal006 and NBSal007 Open
The use of bacteriophages as antimicrobial agents represents a promising alternative for the control of pathogenic bacteria. Here, we present the complete genome sequences of two novel Salmonella enterica lytic bacteriophages, NBSal006 and…
View article: Optimizing bacteriophage engineering through an accelerated evolution platform
Optimizing bacteriophage engineering through an accelerated evolution platform Open
The emergence of antibiotic resistance has raised serious concerns within scientific and medical communities, and has underlined the importance of developing new antimicrobial agents to combat such infections. Bacteriophages, naturally occ…
View article: Complete Genome Sequences of Five Salmonella enterica Phages, NBSal001, NBSal002, NBSal003, NBSal004, and NBSal005
Complete Genome Sequences of Five Salmonella enterica Phages, NBSal001, NBSal002, NBSal003, NBSal004, and NBSal005 Open
Salmonella enterica is a Gram-negative bacterium, recognized as one of the most important foodborne pathogens in the world. Bacteriophages represent a promising alternative to the biocontrol of Salmonella . Here, we report the isolation of…
View article: Draft Genome Sequence of the First New Delhi Metallo-β-Lactamase (NDM-1)-Producing Escherichia coli Strain Isolated in Peru
Draft Genome Sequence of the First New Delhi Metallo-β-Lactamase (NDM-1)-Producing Escherichia coli Strain Isolated in Peru Open
We present here the draft genome sequence of the first New Delhi metallo-β-lactamase (NDM-1)-producing Escherichia coli strain, belonging to sequence type 155 (ST155), isolated in Peru. Assembly of this draft genome resulted in 5,061,184 b…