Carlos del Fresno
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View article: Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection
Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection Open
Ageing is a well-recognised factor influencing immune competence; however, elderly individuals remain underrepresented in clinical trials, resulting in gaps in our understanding of their immune responses to disease. To address this gap, we…
View article: SHIPi improves hematologic recovery after chemotherapy
SHIPi improves hematologic recovery after chemotherapy Open
View article: Extracellular Vesicles as Novel Biomarkers for Tumor Association in Intermediate-Risk Paraneoplastic Neurologic Syndromes
Extracellular Vesicles as Novel Biomarkers for Tumor Association in Intermediate-Risk Paraneoplastic Neurologic Syndromes Open
This study provides Class IV evidence that higher circulating blood levels of EVs can distinguish between tumor-associated PNS from suspected PNS without tumor.
View article: BCG-induced reprogramming of monocyte/macrophage populations enhances lung antitumor immunity in mice
BCG-induced reprogramming of monocyte/macrophage populations enhances lung antitumor immunity in mice Open
The tumor microenvironment (TME) significantly influences antitumor immunity, with monocytes and macrophages playing pivotal roles both in pro- and anti-tumoral functions. Tumor-associated macrophages (TAMs) often adopt immunosuppressive p…
View article: Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort
Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort Open
Introduction Paediatric acute hepatitis of unknown aetiology (PAHUA) has emerged as a global health concern, yet its cause remains unidentified. This study characterises the clinical and immunological profiles of PAHUA to identify reliable…
View article: Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections Open
The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory in…
View article: A blood-based liquid biopsy analyzing soluble immune checkpoints and cytokines identifies distinct neuroendocrine tumors
A blood-based liquid biopsy analyzing soluble immune checkpoints and cytokines identifies distinct neuroendocrine tumors Open
View article: Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow Open
View article: Translocation of gut<i>Enterococcus faecalis</i>trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle
Translocation of gut<i>Enterococcus faecalis</i>trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle Open
Summary Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we explored innate immune responses …
View article: Endotoxin tolerance and trained immunity: breaking down immunological memory barriers
Endotoxin tolerance and trained immunity: breaking down immunological memory barriers Open
For decades, innate immune cells were considered unsophisticated first responders, lacking the adaptive memory of their T and B cell counterparts. However, mounting evidence demonstrates the surprising complexity of innate immunity. Beyond…
View article: Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally
Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally Open
Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin. Nevertheless, considering the clinical…
View article: The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis
The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis Open
Instituto de Salud Carlos III (ISCIII) and "Fondos FEDER" to ELC (PIE15/00065, PI18/00148, PI14/01234, PI21/00869), CDF (PI21/01178), RLR (FI19/00334) and JAO (CD21/00059).
View article: Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung
Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung Open
View article: mRNA-1273 boost after BNT162b2 vaccination generates comparable SARS-CoV-2-specific functional responses in naïve and COVID-19-recovered individuals
mRNA-1273 boost after BNT162b2 vaccination generates comparable SARS-CoV-2-specific functional responses in naïve and COVID-19-recovered individuals Open
Introduction COVID-19 vaccines based on mRNA have represented a revolution in the biomedical research field. The initial two-dose vaccination schedule generates potent humoral and cellular responses, with a massive protective effect agains…
View article: Editorial: Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis
Editorial: Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis Open
EDITORIAL article Front. Immunol., 18 April 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1194504
View article: Heat-Killed <i>Mycobacterium tuberculosis</i> Induces Trained Immunity <i>in vitro</i> and <i>in vivo</i> When Administered Systemically or Intranasally
Heat-Killed <i>Mycobacterium tuberculosis</i> Induces Trained Immunity <i>in vitro</i> and <i>in vivo</i> When Administered Systemically or Intranasally Open
View article: Systemic BCG administration stimulates NK and T cell-mediated antitumor lung immunity and overcomes tumor resistance to immune checkpoint inhibition
Systemic BCG administration stimulates NK and T cell-mediated antitumor lung immunity and overcomes tumor resistance to immune checkpoint inhibition Open
Intravesical administration of BCG was the first immunotherapy approved by the FDA and it is still nowadays the treatment of choice for a subset of non-muscle invasive bladder cancer patients. Considering this precedent and the strong capa…
View article: Fused Cells between Human-Adipose-Derived Mesenchymal Stem Cells and Monocytes Keep Stemness Properties and Acquire High Mobility
Fused Cells between Human-Adipose-Derived Mesenchymal Stem Cells and Monocytes Keep Stemness Properties and Acquire High Mobility Open
Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent stem cells which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they have limited migration and short lifespans. Ther…
View article: Colorectal Cancer Stem Cells Fuse with Monocytes to Form Tumour Hybrid Cells with the Ability to Migrate and Evade the Immune System
Colorectal Cancer Stem Cells Fuse with Monocytes to Form Tumour Hybrid Cells with the Ability to Migrate and Evade the Immune System Open
Background: The cancer cell fusion theory could be one of the best explanations for the metastasis from primary tumours. Methods: Herein, we co-cultured colorectal cancer (CRC) stem cells with human monocytes and analysed the properties of…
View article: Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors
Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors Open
Background Intravesical BCG is the gold-standard therapy for non-muscle invasive bladder cancer (NMIBC); however, it still fails in a significant proportion of patients, so improved treatment options are urgently needed. Methods Here, we c…
View article: Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study
Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study Open
Dear Editor, We have studied humoral and cellular responses in a Spanish cohort of 433 volunteers immunized with four COVID-19 vaccines (Ad26.CoV2.S, BNT162b2, ChAdOx1 and mRNA-1273) approved by the European Medicines Agency (EMA), classif…
View article: Identification of sSIGLEC5 and sLAG3 as New Relapse Predictors in Lung Cancer
Identification of sSIGLEC5 and sLAG3 as New Relapse Predictors in Lung Cancer Open
Lung cancer (LC) continues to be the leading cause of cancer-related deaths in both men and women worldwide. After complete tumour resection, around half of the patients suffer from disease relapse, emphasising the critical need for robust…
View article: Dectin-1 Signaling Update: New Perspectives for Trained Immunity
Dectin-1 Signaling Update: New Perspectives for Trained Immunity Open
The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses. However, over time, different ligands both of microbial-derived and endogenou…
View article: Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections Open
View article: Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19
Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19 Open
View article: The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity
The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity Open
COVID-19-specific vaccines are efficient prophylactic weapons against SARS-CoV-2 virus. However, boosting innate responses may represent an innovative way to immediately fight future emerging viral infections or boost vaccines. MV130 is a …
View article: SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown
SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown Open
View article: The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission
The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission Open
Dear Editor, Despite the improvement in prophylaxis by vaccination, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its associated pathology, COVID-19, still constitute a challenge. Clinicians lack effective trea…
View article: Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients
Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients Open
Colorectal cancer (CRC) is the second most deadly and third most commonly diagnosed cancer worldwide. There is significant heterogeneity among patients with CRC, which hinders the search for a standard approach for the detection of this di…
View article: DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells
DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells Open
Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing rec…